在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Occludin (Ocln)

  • 中文名稱:
    小鼠Ocln重組蛋白
  • 貨號:
    CSB-CF016263MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Ocln; Ocl; Occludin
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-521
  • 氨基酸序列
    MSVRPFESPPPYRPDEFKPNHYAPSNDMYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTS PPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTGLFGGSLNYPYSGFGYGGGYGGGYG GYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAIL GIMVFIATIVYIMGVNPTAQASGSMYGSQIYMICNQFYTPGGTGLYVDQYLYHYCVVDPQ EAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNVS AGTQDMPPPPSDYAERVDSPMAYSSNGKVNGKRSYPESFYKSTPLVPEVAQEIPLTLSVD DFRQPRYSSNGNLETPSKRAPTKGKAGKGKRTDPDHYETDYTTGGESCEELEEDWVREYP PITSDQQRQLYKRNFDAGLQEYKSLQAELDDVNKELSRLDKELDDYREESEEYMAAADEY NRLKQVKGSADYKSKRNYCKQLKSKLSHIKRMVGDYDRRKP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
  • 基因功能參考文獻:
    1. PLD2 is pivotal in the regulation of the integrity of epithelial tight junctions and occludin turn over, thereby implicating it in the pathogenesis of colitis. PMID: 28484281
    2. Adherens as well as tight junction marker proteins were rapidly and consistently upregulated in both the germinal as well as the functional layer of the oral mucosa. This represents a previously unknown parameter of the epithelial radiation response to clinically relevant fractionation protocols. CONCLUSION: Fractionated irradiation significantly enhanced the expression of all proteins investigated. This study revealed a PMID: 29675597
    3. The C-terminal DSP domain induced phosphorylation of occludin Ser(490) and focal adhesion kinase (FAK) Ser(722) and Tyr(576). Coexpression of DSP, occludin and FAK was detected in dental mesenchymal cells during tooth development. Occludin physically interacts with FAK, and occludin and FAK phosphorylation can be blocked by DSP and occludin antibodies. PMID: 28331230
    4. Endothelial cellsTLR4 strongly regulates retinal vessel permeability by reducing expression of occludin and zonula occludens 1. PMID: 29136627
    5. The zinc sensing receptor, ZnR/GPR39, triggers intracellular Ca(2+) signalling in colonocytes thereby inducing occludin expression. Moreover, ZnR/GPR39 is essential for epithelial barrier recovery in the dextran sodium sulfate (DSS) ulcerative colitis model. PMID: 27377730
    6. Occludin expression by epidermal gammadelta T cells upon activation in response to epidermal stress allows them to move, which could be important for augmentation of immune responses via collaboration with other cells. PMID: 28566372
    7. Intracellular zinc has an essential role in the maintenance of the intestinal epithelial tight junction barrier through regulation of occludin proteolysis and claudin-3 transcription. PMID: 27151944
    8. miR-429 could down-regulate the expression of Ocln by targeting the Ocln 3'-UTR, which impaired intestinal barrier function in diabetes mellitus mice. PMID: 27299781
    9. STAT3 activation downregulates the ZO-1 and occludin levels and increases the endothelial permeability through the induction of VEGF production in retinal endothelial cells. PMID: 27580405
    10. Tricellulin is a specific redox sensor and sealing element at 3-cell contacts and may compensate as a redox mediator for occludin loss at 2-cell contacts in vivo and in vitro. PMID: 25919114
    11. These findings provide evidence for occludin playing a role in the invasion of Toxoplasma gondii in small intestinal epithelial cells. PMID: 26183539
    12. occludin deficiency increases susceptibility to ethanol-induced colonic mucosal barrier dysfunction and liver damage in mice. PMID: 26721332
    13. PHD3 protects intestinal epithelial barrier function and reveal a hydroxylase-independent function of PHD3 in stabilizing occludin PMID: 26124271
    14. Zonula occludens-1, occludin and E-cadherin expression and organization in salivary glands PMID: 25248927
    15. Our study demonstrates spatiotemporal alterations in occludin mRNA- and protein-expression, indicating that Cx43 might act as a regulator for blood-testis-barrier PMID: 24497041
    16. Occludin and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis. PMID: 24845399
    17. Hypoxic induction of CAV1 in the colon was essential for intestinal barrier integrity by regulating occludin expression. PMID: 24891620
    18. Activation of RhoA/ROCK1 by high glucose in diabetic nephropathy disrupts the expression and translocation of occludin/ZO-1, which can be corrected by simvastatin. PMID: 24244596
    19. Similar levels of occludin gene expression were detected. PMID: 23568966
    20. actin cytoskeletal dynamics is detrimental to METH-induced BBB dysfunction by increasing internalization of occludin. PMID: 24081143
    21. Occludin showed identical mRNA expression levels in the brains of adult and aged mice. PMID: 22120415
    22. occludin KO gammadelta T cells are defective in both initial accumulation and migration within the intraepithelial compartment PMID: 22511722
    23. show that murine OCLN can sustain HCVcc entry, albeit with about 5-fold reduced efficiency compared to that of human OCLN PMID: 21632765
    24. Suggest occludin plays a crucial role in the maintenance of tight junction barrier through the large-channel TJ pathway, the pathway responsible for the macromolecule flux. PMID: 21415414
    25. The distribution patterns of tight junctions in ameloblasts by observing the expression patterns of OLD and CLDs (CLD-1 to CLD-10), were examined. PMID: 20683698
    26. The tight junction protein occludin (encoded by the OCLN gene) is involved in the pathogenesis of malformations of cortical development. PMID: 20727516
    27. Nedd4-2 interacts with occludin to inhibit tight junction assembly and the regulation of paracellular conductance in the collecting duct. PMID: 20504882
    28. marvelD3, occludin, and tricellulin define the tight junction-associated MARVEL protein family PMID: 20164257
    29. in vivo imaging and transgenic mice expressing fluorescent-tagged occludin and ZO-1 fusion proteins to link occludin endocytosis to TNF-induced tight junction regulation. PMID: 20351069
    30. suggest that occludin has a protective as well as a barrier forming role in epithelia. PMID: 20003227
    31. Surface plasmon resonance study of interaction of occludin with ZO-1 PMID: 11700038
    32. E-cadherin and claudins/occludin have roles in the regulation of tight junctions during the epithelium-mesenchyme transition, but are repressed by snail PMID: 12668723
    33. Data show that occludin is involved in establishing the blastocoel, in maintaining its impermeability, and that the development of tight junctions is critical for trophectoderm formation in mouse embryos. PMID: 15179038
    34. common molecular mechanism of forming a helical bundle between the hinge region/GuK domain of ZO-1 and alpha-catenin and occludin is identified as a general molecular principle organizing the association of ZO-1 at adherens and tight junctions PMID: 15548514
    35. Loss of occludin expression is at least partially involved in the senescence-escape program during mammary tumorigenesis. PMID: 17459053
    36. Amyotrophic lateral sclerosis-linked superoxide dismutase 1 (SOD1) mutants with different biochemical characteristics disrupted the blood-spinal cord barrier in mice by reducing the levels of the tight junction protein occludin. PMID: 18344992
    37. Describe method to study the intracellular transport of occludin to and from the cell surface in both fibroblasts and epithelial cells. PMID: 18369939
    38. In mouse cerebral cortex, microinjection of VEGF-A disrupted CLN-5 and OCLN and induced loss of barrier function PMID: 19174516
    39. the pro-inflammatory chemokine CCL2 mediates brain endothelial barrier disruption during CNS inflammation PMID: 19423710
    40. The oligomerization of the coiled coil-domain of occluddin is redox sensitive PMID: 19538283
    41. Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure. PMID: 19821483

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, tight junction.
  • 蛋白家族:
    ELL/occludin family
  • 組織特異性:
    Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in the testis, kidney, lung, liver and brain. Not detected in skeletal muscle, spleen and heart.
  • 數據庫鏈接:


主站蜘蛛池模板: 在线视频 亚太 国产 欧美 一区二区| 欧美牲交视频免费观看| 亚洲国产精品成人精品无码区蜜臀| 婷婷成人五月综合激情| 国内丰满熟女出轨videos| 久久97超碰色中文字幕蜜芽| 国产精品va无码免费| 国产精品水嫩水嫩| 久久久久人妻一区精品色欧美| 男人的好看免费观看在线视频| 亚洲大色堂人在线无码| 永久免费精品成人网站| 亚洲精品1卡2卡三卡23卡| 国产普通话对白刺激| 亚洲精品国产精华液| 久久久久久国产精品免费免费男同| 亚洲熟女久久色| 中国china体内裑精亚洲日本| 久青草国产97香蕉在线视频| 国产久久精品| 国产一区二区三区乱码在线观看| 东北少妇不戴套对白第一次| 四虎亚洲精品无码| 国产国产裸模裸模私拍视频| 久久精品国产一区二区三区不卡| 无码av波多野结衣久久| 亚洲国产成人精品青青草原| 国色天香社区视频手机免费| 在线播放亚洲人成电影| 日本三级香港三级三级人!妇久| 国产精品自在在线午夜| 成年男人裸j照无遮挡无码| 国精品99久9在线 | 免费| 亚洲无线卡一卡二| 女人与拘做受全过程免费视频| 免费观看的av在线播放| 日日摸日日碰夜夜爽无码| 成人性生交大免费看| 天天爽天天爽天天爽| 五月色丁香婷婷网蜜臀av| 国语自产拍在线观看对白|