在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Nociceptin receptor (Oprl1)

Recombinant Mouse Nociceptin receptor (Oprl1)

  • 中文名稱：
    小鼠Oprl1重組蛋白
  • 貨號：
    CSB-CF016360MO
  • 規格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Oprl1; Oor; Oprl; Nociceptin receptor; K3 opiate receptor; Kappa-type 3 opioid receptor; KOR-3; ORGC; Orphanin FQ receptor
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-367
  • 氨基酸序列
    MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCI GGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALC KTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGV PVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLR GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRF CTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTS ETVPRPA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
  • 基因功能參考文獻：
    1. nociceptin opioid receptor agonists are promising drugs for treating pain in sickle cell anemia. PMID: 26294734
    2. These knock-in mice have NOP receptors that function both in vitro and in vivo and have provided a detailed characterization of NOP receptors in brain, spinal cord, and DRG neurons. PMID: 26290245
    3. Oprl1 is associated with amygdala function, fear processing, and posttraumatic stress disorder symptoms. PMID: 23740899
    4. Data suggest that NOPR and MOPR (mu-type opioid receptor) in spinal cord independently drive antinociception; NOPR/MOPR ligands attenuate neuropathic/inflammatory pain and have high antinociceptive potency with low tolerance development. PMID: 23652222
    5. Data suggest that nociceptin receptor/nociceptin signaling plays a role in the disease pathogenesis of inflammatory bowel diseases. PMID: 22449384
    6. The results of this study demonstrated the contribution of the NOP receptor in controlling food intake and meal pattern, as well as glutamate release and GIRK1 channel activity at POMC synapses. PMID: 20510254
    7. These results suggest differential requirements for ORL(1) in the mediation of neuroimmune effects exerted at different times after an immune challenge. PMID: 19913923
    8. OPR is not crucial for development of either acute or neuropathic nociceptive responses, or for the regulation of full receptor-mediated responses to opioid agonists PMID: 12217419
    9. The region-specific up-regulation of the opioid receptor-like 1 receptor indicates a tonic role for nociceptin/orphanin FQ in some brain structures and may suggest the peptide regulates the receptor expression in these regions. PMID: 12605902
    10. Place cells in nociceptin receptor knockout mice were abnormal in several ways: they were less stable, had noisier positional firing patterns, larger firing fields and higher discharge rates inside and outside the firing fields PMID: 15774528
    11. NOC receptor is involved in hippocampal cholinergic function PMID: 15979594
    12. RGS19 prefers regulating ORL1 receptor signaling over other opioid receptors, and the N-terminal domain of RGS19 plays a crucial role in its receptor preference PMID: 16219326
    13. nociceptin receptor has a role in the antinociceptive action of nitrous oxide PMID: 16931689
    14. Nociceptin released from interneurons by their high-frequency activation is a novel endogenous neuromodulator that negatively regulates induction of long-term potentiation in the hippocampus through direct modulation of pyramidal cells. PMID: 17475793
    15. the ability of buprenorphine to interact with the ORL1 receptor modulates its acute motor stimulatory and rewarding effects. PMID: 18634857
    16. findings demonstrate the existence of functional antagonism between nociceptin opioid peptide receptor and NMDA receptors that predominantly contributes to modulation of conditioned fear learning which involves spatial-processing demands PMID: 19100850
    17. Mice lacking the influence of endogenous N/OFQ are hypersensitive to nicotine in most measures, showing a role of endogenous nociceptin in modulating or mediating the acute effects of nicotine, and possibly nicotine addiction. PMID: 19371589

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    In the brain, isoform KOR3 and isoform KOR3C are most abundant in hypothalamus and periaqueductal gray. Isoform KOR3A is highly expressed in cortex, striatum and brainstem. Isoform KOR3D is highly expressed in cerebellum, hypothalamus and brainstem. Detec
  • 數據庫鏈接：


主站蜘蛛池模板： 欧美肉大捧一进一出免费视频| 国产69精品久久久久乱码韩国| 精品无码人妻一区二区免费蜜桃| 小sao货水好多真紧h视频| 国产午夜亚洲精品不卡| 国语精品福利自产拍在线观看 | 国产精品va在线观看无码 | 搡8o老女人老妇人老熟| 中文在线а天堂| 国产成 人 综合 亚洲| 午夜男女xx00视频福利| 无码国产精品一区二区免费式芒果| 少妇特殊按摩高潮惨叫无码| 日本欧美一区二区三区在线播放 | 开心色婷婷色五月激情| 久久精品国产99久久久| 99视频偷窥在线精品国自产拍| 国产人成无码视频在线| 无遮无挡爽爽免费视频| 人妻av乱片av出轨av| 欧洲极品少妇| 国产日韩精品一区二区三区在线| 最新版天堂资源中文官网| 777午夜福利理伦电影网| 欧美性受xxxx狂喷水| 豆国产96在线 | 亚洲| 黑人巨大无码中文字幕无码| 午夜福利免费0948视频| 久久综合亚洲色hezyo社区| 国产国语毛片在线看国产| 正在播放酒店约少妇高潮| 日韩国产人妻一区二区三区| 国产精品久久久久久亚洲影视内衣| 亚洲国产欧美一区点击进入| 成人网站www污污污网站| 粉嫩av国产一区二区三区| 蜜桃一区二区三区| 麻豆国产人妻欲求不满| 国产高清国产精品国产专区| 艳妇乳肉豪妇荡乳| 一本一道av中文字幕无码|