在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Lipase maturation factor 1 (Lmf1)

  • 中文名稱:
    小鼠Lmf1重組蛋白
  • 貨號:
    CSB-CF013000MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Lmf1
  • Uniprot No.:
  • 別名:
    Lmf1; Tmem112; Lipase maturation factor 1; Transmembrane protein 112
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-574
  • 氨基酸序列
    MRPDSLVMAAPEGSLRKRKVGGAEHSPASQPSLARDPADSPARLHTGTFWLTRIVLLRAL AFIYFVAFLVAFNQNKALIGDRGLLPCKLYLKNVQEYFQGSTGWAAWTYAPTIMWLLDWS DMNFNLDLIALLGLGISSFVLVTGCANMILMTALWALYMSLVNVGQIWYSFGWESQLLET GFLGIFLSPLWTLSRLPKNTPTSQIVLWGFRWLIFRIMLGAGLIKVRGDKCWLDLTCMDF HYETQPVPNPIAYYLHRSPWWFHRFETLSNHFVELLVPFFLFLGRRMRILHGVLQILFQV ILIISGNLSFLNWLTIVPSLACFDDAALGFLFPSGPQGLKKQVLEIQREDTQRVQPKPRD RGCLVRQVVNISLGILVAWLSVPVVINLLSSRQIMNTSFNPLRIVNTYGAFGSVTKERTE VILQGTVSPNASAPDAVWEDYEFKCKPGDPWRQPCLISPYHYRLDWLMWFAAFQTYEQNE WILHLAGKLLAGDSEALALLAVNPFEGRTPPRWIRGEHYRYKFSLPGGQHATQGKWWIRK RIGPYFPPLRLEDLKEYFKTREWPLPEPPSRHTR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL.
  • 基因功能參考文獻:
    1. determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells PMID: 25035425
    2. variation in Lmf1 expression is a posttranslational determinant of LPL activity. PMID: 22345169
    3. Lipase maturation factor 1 (Lmf1) is required for endothelial lipase activity. Mutations in Lmf1 result in severe hypertriglyceridemia in mice as well as in human subjects. PMID: 21447484
    4. Results show that cotransfection of LPL with wild-type Lmf1 restores its ability to support normal lipase maturation. PMID: 19471043
    5. Data show that shows the arrangement of an evolutionarily conserved domain within LMF1 (DUF1222) that is essential to lipase maturation. PMID: 19783858
    6. Study identified the gene containing the cld mutation as Tmem112 and rename it Lmf1 (Lipase maturation factor 1); Lmf1 encodes a transmembrane protein with an evolutionarily conserved domain of unknown function that localizes to the ER. PMID: 17994020

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Defects in Lmf1 are the cause of combined lipase deficiency (cld). Cld is characterized by severe hypertriglyceridemia with accumulation of chylomicrons that gradually pack the lumina of capillaries and sinusoids. Severe hypertriglyceridemia causes an increase in blood viscosity, ischemia, and cyanosis, and the inability of tissues to access circulating triglycerides results in starvation, poor thermoregulation, and death 2 to 3 days after birth. The disorder is caused by a decrease in the activity of lipoprotein lipase (Lpl) and the related hepatic lipase (Lipc), caused by impaired maturation of nascent Lpl and hepatic lipase polypeptides in the endoplasmic reticulum.
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Lipase maturation factor family
  • 組織特異性:
    Expressed in all tissues synthesizing lipoprotein lipase (Lpl) and hepatic lipase (Lipc), including adipose tissue, skeletal muscle, heart, and liver. Expressed at higher levels in tissues that express little or no lipase activity such as testis and pancr
  • 數據庫鏈接:


主站蜘蛛池模板: 国产精品毛多多水多| 永久免费精品精品永久-夜色| 亚洲欧洲无卡二区视頻| 国产精品色情国产三级在| 国产jjizz女人多水| 天天影视性色香欲综合网| 又大又紧又粉嫩18p少妇 | 搡女人真爽免费视频大全| 久久五月精品中文字幕| 无遮无挡三级动态图| 尤物yw午夜国产精品大臿蕉| 中文字幕中文有码在线| 中国丰满熟妇av| 麻豆成人精品国产免费| 99久久久无码国产精品性| 亚洲理论在线a中文字幕| 性一交一乱一伦一| 久久精品亚洲中文字幕无码麻豆| 亚洲综合另类小说色区一| 亚洲国产成人av在线观看| 久久精品囯产精品亚洲| 在线精品国产大象香蕉网| 免费无码精品黄av电影| 欧美一区二区三区激情| 国产99视频精品免费视看9 | 久久久亚洲精品av无码| 夫妻免费无码v看片| 国精产品一品二品国精品69xx| 国产清纯白嫩初高生在线观看| 人人爽天天碰狠狠添| 无码精品黑人一区二区三区| 欧美性插b在线视频网站| 精品麻豆丝袜高跟鞋av| 9lporm自拍视频区| 久久久久成人网站| 首页 综合国产 亚洲 丝袜 | а√天堂www在线а√天堂视频| 经典三级欧美在线播放| 男女后式激烈动态图片| 国产人妻黑人一区二区三区| 久久婷婷国产剧情内射白浆|