在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Leukosialin (Spn)

  • 中文名稱:
    小鼠Spn重組蛋白
  • 貨號:
    CSB-CF022590MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Spn; Leukosialin; B-cell differentiation antigen LP-3; Leukocyte sialoglycoprotein; Lymphocyte antigen 48; Ly-48; Sialophorin; CD antigen CD43
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    20-395
  • 氨基酸序列
    DSLQRTTMLPSTPHITAPSTSEAQNASPSVSVGSGTVDSKETISPWGQTTIPVSLTPLETTELSSLETSAGASMSTPVPEPTASQEVSSKTSALLPEPSNVASDPPVTAANPVTDGPAANPVTDGTAASTSISKGTSAPPTTVTTSSNETSGPSVATTVSSKTSGPPVTTATGSLGPSSEMHGLPATTATSSVESSSVARGTSVSSRKTSTTSTQDPITTRSPSQESSGMLLVPMLIALVVVLALVALLLLWRQRQKRRTGALTLSGGGKRNGVVDAWAGPARVPDEEATTTSGAGGNKGSEVLETEGSGQRPTLTTFFSRRKSRQGSLVLEELKPGSGPNLKGEEEPLVGSEDEAVETPTSDGPQAKDEAAPQSL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1.; Protects cells from apoptotic signals, promoting cell survival.
  • 基因功能參考文獻:
    1. glycosylation status of CD43 protein on leukemia cells is associated with sensitivity to CTL-mediated cytolysis PMID: 27011118
    2. findings demonstrate that CD43 is a major E-selectin ligand in Th17 cells that functions independent of P-selectin glycoprotein ligand-1 PMID: 26700769
    3. CD43 may be an important mediator of macrophage lipid homeostasis, thereby affecting macrophage foam cell formation and ultimately atherosclerotic plaque development. PMID: 25524774
    4. We have identified a robust physiologic role for CD43 in a relevant animal model and established an important in vivo function for CD43-dependent regulation of IFN-gamma production. PMID: 23585675
    5. Results show that while CD43 binding to ezrin-radixin-moesin proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism. PMID: 21289089
    6. study found that the M. tuberculosis Cpn60.2 molecular chaperone is the major mycobacterial surface ligand that interacts with CD43 to stabilize the interaction between M. tuberculosis and the macrophage PMID: 20633027
    7. Transient resistance to B16F10 melanoma growth and metastasis in CD43-/- mice. PMID: 11828253
    8. CD43 engagement and signaling are involved in the costimulatory and antiapoptotic effects of enzymatically inactive mutant trypanosomal trans-sialidase when it binds highly sialylated mucin CD43 on the T cell surface. PMID: 11994475
    9. Cd43 displays dynamic roles in T cell immunity: a positive regulatory role in costimulation and trafficking of T cells to the central nervous system, and a negative regulatory role in the down-modulation of an immune response. PMID: 12055210
    10. Delayed onset of experimental autoimmune encephalomyelitis in CD43-deficient immunized mice and in recipients of adoptively transferred CD43-/- cells is characterized by significant reduction of T cell trafficking to the brain and spinal cord. PMID: 14662853
    11. Exclusion of the CD43 intracellular region from the immunological synapse is required for CD43 regulation of interleukin-2 production. PMID: 15117976
    12. Two functionally distinct populations of small intestinal intraepithelial lymphocytes (IELs) are described that differ according to the expression of a CD43 glycoform. PMID: 15528368
    13. CD43 is involved in the binding, uptake, and subsequent growth of Mycobacterium tuberculosis in murine macrophages and in vivo PMID: 16034122
    14. That CD43 costimulation was responsible for elevated cytokine/chemokine activity was confirmed at the transcriptional level by real-time PCR for IFN-gamma and CCL5, and by ELISA for IFN-gamma. PMID: 16246302
    15. CD43, when modified by a specific set of glycosyltranferases, can function as an E-selectin ligand and therefore potentially mediate activated T cell migration PMID: 16339541
    16. These results characterize an important role for CD43 during the activation and expansion of autoreactive MOG-specific CD8+ T cells. PMID: 16890924
    17. Recruitment of neutrophils and activated T cells in in vivo models is not influenced by CD43 expression. PMID: 17056577
    18. CD43 functions as a signaling molecule, sensing extracellular cues and transducing intracellular signals that modulate T-cell function PMID: 17638845
    19. results demonstrate that CD43 regulates Th cell differentiation in vitro and in vivo PMID: 18490738
    20. The authors propose that CD43 is involved in the inflammatory response to M. tuberculosis and, through the induction of pro-inflammatory mediators, can regulate apoptosis to control intracellular growth of the bacterium. PMID: 18637079
    21. The loss of both PSGL-1 and CD43 led to a further increase in T cell adhesion and proliferation PMID: 19890058

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Cell projection, microvillus. Cell projection, uropodium.; [CD43 cytoplasmic tail]: Nucleus. Nucleus, PML body.
  • 組織特異性:
    Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
  • 數據庫鏈接:


主站蜘蛛池模板: 日韩精品成人无码专区免费| 2021国产精品一卡2卡三卡4卡| 狠狠色噜噜狠狠狠狠av不卡| 特级a欧美做爰片三人交| 亚洲 日韩 国产 中文有码| 免费无码a片一区二三区| 亚洲成a人v在线蜜臀| 999久久久精品国产消防器材| 国产精品va在线观看老妇女| 亚洲狠狠爱综合影院网页| 亚洲精品久久久av无码专区| 中文字幕乱码熟妇五十中出色欲| 国内精品久久久久影院亚瑟| 国产乱沈阳女人高潮乱叫老 | 亚洲综合无码一区二区三区| 亚洲成av人片在一线观看| 亚洲国产一区二区三区在观看| 2020年国产精品| 真人一进一出120秒试看| awww在线天堂bd资源在线| 亚洲欧洲美洲在线观看| 小宝极品内射国产在线| 欧美性xxxxx极品娇小| 成人乱人乱一区二区三区| 欧美老妇bbbwwbbbww| 亚洲国产超清无码专区| 午夜亚洲国产理论片二级港台二级| 国产精品无码v在线观看| 影音先锋人妻啪啪av资源网站 | 少妇爆乳无码专区| 国色天香中文字幕在线视频| 成人欧美一区二区三区在线观看| 日产无码中文字幕av| 两性色午夜视频免费播放| 色94色欧美sute亚洲线路一| 亚洲成a人片在线观看中文无码| 国模gogo无码人体啪啪| 九九九免费观看视频| 亚无码乱人伦一区二区| 久久精品人妻无码一区二区三区v| 人妻系列无码专区喂奶|