在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Leukosialin (Spn)

  • 中文名稱:
    小鼠Spn重組蛋白
  • 貨號:
    CSB-CF022590MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Spn; Leukosialin; B-cell differentiation antigen LP-3; Leukocyte sialoglycoprotein; Lymphocyte antigen 48; Ly-48; Sialophorin; CD antigen CD43
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    20-395
  • 氨基酸序列
    DSLQRTTMLPSTPHITAPSTSEAQNASPSVSVGSGTVDSKETISPWGQTTIPVSLTPLETTELSSLETSAGASMSTPVPEPTASQEVSSKTSALLPEPSNVASDPPVTAANPVTDGPAANPVTDGTAASTSISKGTSAPPTTVTTSSNETSGPSVATTVSSKTSGPPVTTATGSLGPSSEMHGLPATTATSSVESSSVARGTSVSSRKTSTTSTQDPITTRSPSQESSGMLLVPMLIALVVVLALVALLLLWRQRQKRRTGALTLSGGGKRNGVVDAWAGPARVPDEEATTTSGAGGNKGSEVLETEGSGQRPTLTTFFSRRKSRQGSLVLEELKPGSGPNLKGEEEPLVGSEDEAVETPTSDGPQAKDEAAPQSL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1.; Protects cells from apoptotic signals, promoting cell survival.
  • 基因功能參考文獻:
    1. glycosylation status of CD43 protein on leukemia cells is associated with sensitivity to CTL-mediated cytolysis PMID: 27011118
    2. findings demonstrate that CD43 is a major E-selectin ligand in Th17 cells that functions independent of P-selectin glycoprotein ligand-1 PMID: 26700769
    3. CD43 may be an important mediator of macrophage lipid homeostasis, thereby affecting macrophage foam cell formation and ultimately atherosclerotic plaque development. PMID: 25524774
    4. We have identified a robust physiologic role for CD43 in a relevant animal model and established an important in vivo function for CD43-dependent regulation of IFN-gamma production. PMID: 23585675
    5. Results show that while CD43 binding to ezrin-radixin-moesin proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism. PMID: 21289089
    6. study found that the M. tuberculosis Cpn60.2 molecular chaperone is the major mycobacterial surface ligand that interacts with CD43 to stabilize the interaction between M. tuberculosis and the macrophage PMID: 20633027
    7. Transient resistance to B16F10 melanoma growth and metastasis in CD43-/- mice. PMID: 11828253
    8. CD43 engagement and signaling are involved in the costimulatory and antiapoptotic effects of enzymatically inactive mutant trypanosomal trans-sialidase when it binds highly sialylated mucin CD43 on the T cell surface. PMID: 11994475
    9. Cd43 displays dynamic roles in T cell immunity: a positive regulatory role in costimulation and trafficking of T cells to the central nervous system, and a negative regulatory role in the down-modulation of an immune response. PMID: 12055210
    10. Delayed onset of experimental autoimmune encephalomyelitis in CD43-deficient immunized mice and in recipients of adoptively transferred CD43-/- cells is characterized by significant reduction of T cell trafficking to the brain and spinal cord. PMID: 14662853
    11. Exclusion of the CD43 intracellular region from the immunological synapse is required for CD43 regulation of interleukin-2 production. PMID: 15117976
    12. Two functionally distinct populations of small intestinal intraepithelial lymphocytes (IELs) are described that differ according to the expression of a CD43 glycoform. PMID: 15528368
    13. CD43 is involved in the binding, uptake, and subsequent growth of Mycobacterium tuberculosis in murine macrophages and in vivo PMID: 16034122
    14. That CD43 costimulation was responsible for elevated cytokine/chemokine activity was confirmed at the transcriptional level by real-time PCR for IFN-gamma and CCL5, and by ELISA for IFN-gamma. PMID: 16246302
    15. CD43, when modified by a specific set of glycosyltranferases, can function as an E-selectin ligand and therefore potentially mediate activated T cell migration PMID: 16339541
    16. These results characterize an important role for CD43 during the activation and expansion of autoreactive MOG-specific CD8+ T cells. PMID: 16890924
    17. Recruitment of neutrophils and activated T cells in in vivo models is not influenced by CD43 expression. PMID: 17056577
    18. CD43 functions as a signaling molecule, sensing extracellular cues and transducing intracellular signals that modulate T-cell function PMID: 17638845
    19. results demonstrate that CD43 regulates Th cell differentiation in vitro and in vivo PMID: 18490738
    20. The authors propose that CD43 is involved in the inflammatory response to M. tuberculosis and, through the induction of pro-inflammatory mediators, can regulate apoptosis to control intracellular growth of the bacterium. PMID: 18637079
    21. The loss of both PSGL-1 and CD43 led to a further increase in T cell adhesion and proliferation PMID: 19890058

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Cell projection, microvillus. Cell projection, uropodium.; [CD43 cytoplasmic tail]: Nucleus. Nucleus, PML body.
  • 組織特異性:
    Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
  • 數據庫鏈接:


主站蜘蛛池模板: 国产精品爽爽v在线观看无码| 一本一道波多野结衣一区| 中文字幕aav| 无码人妻一区二区中文| 国产免费二卡3卡四卡| 国产欧美亚洲精品a| 国产女主播喷水视频在线观看| 国产精品欧美一区二区三区| 国产精品点击进入在线影院高清| 亚洲一区二区三区波多野结衣| 麻豆精品久久久久久中文字幕无码| 亚洲伊人成无码综合网| 熟女体下毛毛黑森林| 男人撕开奶罩揉吮奶头视频| 男插女高潮一区二区| 色综合视频一区二区三区44| 欧美又粗又大aaa片| 在线观看无码不卡av| 亚洲性夜夜天天天| 色播在线精品一区二区三区四区| 五十路熟妇高熟无码视频| 色婷婷欧美在线播放内射| 99e久热只有精品8在线直播| 午夜电影网va内射| 国产午夜福利小视频合集| 国产精品久久久福利| 无码免费毛片手机在线无卡顿| 中文无码精品a∨在线观看不卡| 无码中出人妻中文字幕av| 国产精品福利一区二区久久| 亚洲综合国产成人丁香五月激情| аⅴ天堂中文在线网官网| 无码动漫性爽xo视频在线观看| 亚洲精品午夜一区二区电影院| 日本免费高清线视频免费| 毛片无码一区二区三区a片视频| 色情久久久av熟女人妻网站| av蓝导航精品导航| 亚洲六月丁香六月婷婷| 成年美女黄网站色大片免费看| 国产精品久久久久久影视|