在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Exostosin-1 (Ext1)

  • 中文名稱:
    小鼠Ext1重組蛋白
  • 貨號:
    CSB-CF007899MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Ext1
  • Uniprot No.:
  • 別名:
    Ext1; Exostosin-1; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 1 homolog
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-746
  • 氨基酸序列
    MQAKKRYFILLSAGSCLALLFYFGGVQFRASRSHSRREEHSGRNGLHQPSPDHFWPRFPDALRPFFPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVLLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVIVIEGESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIERL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan.
  • 基因功能參考文獻:
    1. reactivating SHH signaling in mutant lungs rescued the tip dilation phenotype and attenuated FGF signaling. Importantly, the reduced SHH signaling activity did not appear to be caused by decreased Shh expression or protein stability; instead, biologically active form of SHH proteins were reduced in both the Ext1 mutant epithelium and surrounding wild type mesenchymal cells. PMID: 28859094
    2. crucial for outflow tract formation in distinct progenitor cells and modulates FGF signaling during early heart development PMID: 26295701
    3. Normal heparin sulfate levels and Ext1 activity in the stromal microenvironment and hematopoietic stem cells are required for the transplant engraftment following non-myeloablative conditioning. PMID: 25976459
    4. Heterozygous loss of function of EXT1 and EXT2 results in a decreased arteriolar endothelial glycocalyx but improved flow mediated vasodilation. PMID: 25468659
    5. Ext genes and heparan sulfate are needed to establish and maintain perichondrium's phenotype and border function. PMID: 23458899
    6. Levels of Ext1 and HPSE influence the motility of FBJ osteosarcoma cells. PMID: 23054193
    7. stromal Ext1-levels modulate tumor cell proliferation and affect the interstitial fluid pressure in a 3-D spheroid model. PMID: 22848466
    8. The study indicates that formation of stereotypic exostoses requires a significant, but not complete, loss of Ext expression. PMID: 21310272
    9. local Ext1 expression and heparan sulfate production are needed to maintain the phenotype and function of joint-forming cells. PMID: 21185280
    10. Ext1 has a role in regulation of bone morphogenic protein signaling and skeletal defects PMID: 20404326
    11. inactivation of Ext1 in a small fraction of chondrocytes is sufficient for the development of osteochondromas and other skeletal defects associated with multiple hereditary exostoses PMID: 20534475
    12. for a model of multiple osteochondromas, we created the chimeric tissue genotype of somatic loss of heterozygosity, by conditionally inactivating Ext1 in chondrocytes PMID: 20080592
    13. loss of heterozygosity is required for osteochondroma formation and a proliferating chondrocyte is suggested as its cell of origin PMID: 20133829
    14. Induction of EXT1 knockdown in vivo dramatically suppresses the growth of bone marrow localized myeloma. PMID: 19965677
    15. Data suggest that the length of the heparan sulfate (HS) chains is a critical determinant of HS-protein interactions and emphasize the essential role of EXT1 in providing specific binding sites for growth factors and extracellular matrix proteins. PMID: 19850926
    16. EXT1 peaks during early postnatal period in the cerebrum and around birth in the cerebellum. EXT1 was localized primarily in the neuroepithelial cells surrounding the lateral ventricles, the mesencephalic vesicle, and the fourth ventricle. PMID: 12644256
    17. Ext1 may have a role in normal mouse development PMID: 15161920
    18. Reduced heparan sulfate synthesis in mice carrying a hypomorphic mutation in Ext1 results in an elevated range of Indian hedgehog (Ihh) signaling during embryonic chondrocyte differentiation. PMID: 15177029
    19. Defects in EXT1 and the resulting reduction in heparan sulfate lead to enhanced Indian hedgehog diffusion causing an increase in chondrocyte proliferation and delayed hypertrophic differentiation. PMID: 15777636
    20. NDST1 competes with EXT1 for binding to EXT2. PMID: 18337501

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Glycosyltransferase 47 family
  • 組織特異性:
    Expressed in maturing chondrocytes.
  • 數據庫鏈接:


主站蜘蛛池模板: 伊人久久综合无码成人网| 暖暖 免费 高清 日本 在线| 天堂最新版资源网| 四虎永久地址www成人久久| 国产精品无码无卡在线播放| 欧美日韩在线第一页免费观看 | 小说区 图片区色 综合区| 欧美牲交a欧美在线| 午夜成人无码片在线观看影院| 黑人大战日本人妻嗷嗷叫不卡视频| 久久精品国产成人av| 中国女人内射6xxxxx| 在线观看成人年视频免费| 亚洲中文在线精品国产| 亚洲成av人片在线观看www| 亚洲一区二区女搞男| 美女粉嫩饱满的一线天mp4| 色偷偷一区二区无码视频| 国产高清在线a视频大全| 色先锋资源久久综合5566| 日本护士xxxxhd少妇| 麻豆md0077饥渴少妇| 色妞色视频一区二区三区四区| 人妻熟女一区二区aⅴ图片| 国精产品蘑菇一区一区有限| 成人网站在线进入爽爽爽| 亚洲精品久久国产高清情趣图文| 日韩精品国产另类专区| 亚洲国产欧美在线人成最新| 精品国产乱码久久久久久郑州公司| 99在线精品一区二区三区| 中文字幕日产乱码国内自| 国产激情з∠视频一区二区 | 中文在线中文a| 国产欧美一区二区精品仙草咪| 狠狠色狠狠色综合网| 人妻丰满熟妇av无码区不卡| 亚洲午夜成人精品无码app| 欧美精品v国产精品v日韩精品| 亚洲成av人在线视| 免费无码黄动漫十八禁|