在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Emerin (Emd)

Recombinant Mouse Emerin (Emd)

  • 中文名稱：
    小鼠Emd重組蛋白
  • 貨號：
    CSB-CF007633MO
  • 規格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
    Emd
  • Uniprot No.：
  • 別名：
    Emd; Sta; Emerin
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-259
  • 氨基酸序列
    MDDYAVLSDTELAAVLRQYNIPHGPIVGSTRKLYEKKIFEYETQRRRLLPPNSSSSSFSY QFSDLDSAAVDSDMYDLPKKEDALLYQSKDYNDDYYEESYLTTKTYGEPESVGMSKSFRQ PGTSLVDADTFHHQVRDDIFSSLEEEGKDRERLIYGQDSAYQSIAHYRPISNVSRSSLGL SYYPTSSTSSVSSSSSSPSSWLTRRAIRPEKQAPAAALGQDRQVPLWGQLLLFLVFAAFL LFVYYSIQAEEGNPFWMDP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C.
  • 基因功能參考文獻：
    1. these data indicate that Emerin, a conserved nuclear lamina protein, couples extracellular matrix mechanics and SRF-Mkl1-dependent transcription. PMID: 28576971
    2. Emerin-null progenitors were delayed in their cell cycle exit, had decreased myosin heavy chain (MyHC) expression and formed fewer myotubes. Emerin binds to and activates histone deacetylase 3 (HDAC3). PMID: 28188262
    3. changes in nuclear size and shape, which are mediated by nuclear envelope structural proteins lamin A/C and/or emerin, also impact gene regulation and lineage differentiation in early embryos. PMID: 28088180
    4. Results suggest that emerin protein is an essential component of the cellular apparatus constraining and fine-tuning Wnt/b-catenin signaling in the heart providing tight control of cardiomyocyte numbers. PMID: 25274778
    5. emerin functions with myosin IIB to polarize actin flow and nuclear movement in fibroblasts, suggesting a novel function for the nuclear envelope in organizing directional actin flow and cytoplasmic polarity. PMID: 24152738
    6. Interactions between HDAC3 and Emerin mediate the interaction of myogenic regulatory loci with the nuclear lamina. PMID: 24062260
    7. a novel mechanism that could provide insight into the disease aetiology for the cardiac phenotype in many laminopathies, whereby lamin A/C and emerin regulate gene expression through modulation of nuclear and cytoskeletal actin polymerization PMID: 23644458
    8. report significant perturbations in the expression and activation of p38/Mapk14 in emerin-null myogenic progenitors, showing that perturbed expression of Wnt, IGF-1, TGF-beta, and Notch signaling components disrupts normal downstream myogenic signaling PMID: 22606356
    9. emerin facilitates repressive chromatin formation at the nuclear periphery by increasing the catalytic activity of HDAC PMID: 22570481
    10. These findings suggest roles for emerin as a downstream effector and signal integrator for tyrosine kinase signaling pathway(s) at the nuclear envelope. PMID: 19789182
    11. emerin and lamin A/C are bound to actin at the late stages of myotube differentiation PMID: 12670476
    12. the lamin a-emerin complex might have a role in muscular dystrophy and cardiomyopathy PMID: 12783988
    13. Data show that emerin-deficient mouse embryo fibroblasts have apparently normal nuclear mechanics but impaired expression of mechanosensitive genes in response to strain. PMID: 16115958
    14. Emerin deficiency causes minimal motor and cardiac dysfunctions in mice with a structural fragility of myonuclei. PMID: 16507906
    15. Altered nuclear envelope elasticity caused by loss of emerin could contribute to increased nuclear fragility in Emery-Dreifuss muscular dystrophy patients with mutations in the emerin gene. PMID: 16997877
    16. Data show that both downregulation of LUMA and overexpression of dominant-negative acting LUMA fragments causes redistribution of emerin. PMID: 18230648
    17. Knockdown of A-type lamins and emerin in HeLa and C2C12 stimulated phosphorylation and nuclear translocation of ERK as well as activation of genes encoding downstream transcription factors. PMID: 19022376
    18. Deregulation of cell signaling contributes to nuclear envelope-linked disorders and suggests that mutations in NET25 and MAN1 may cause muscle diseases. PMID: 19720741

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane.
  • 組織特異性：
    Detected in embryonic fibroblasts, skeletal muscle, heart muscle and tongue epithelium (at protein level). Widely expressed.
  • 數據庫鏈接：


主站蜘蛛池模板： 色天天天综合色天天| 99re久久精品国产| 久久久久欧美精品| 99久久国产露脸精品国产麻豆 | 97se狠狠狠狠狼鲁亚洲综合色| 精品无码国产自产在线观看水浒传 | 六十熟妇乱子伦视频| 美女扒开奶罩露出奶头视频网站 | 99大香伊乱码一区二区| 久久久久高潮综合影院| 人妻中文字幕乱人伦在线| 电影内射视频免费观看| 51福利国产在线观看午夜天堂| 三上悠亚ssⅰn939无码播放| 午夜无码乱码在线观看| 中文字幕丝袜精品久久| 白丝爆浆18禁一区二区三区| 日韩精品久久无码人妻中文字幕| 精品无码av无码专区| 性一交一乱一伦一| 国产女人高潮毛片| 国产免费mv大片人人电影播放器| 国产乱了真实在线观看| 秋霞最新高清无码鲁丝片| 久久久久人妻一区精品果冻| 日本边添边摸边做边爱的网站| 无码精品国产一区二区三区免费| 天堂在线最新版资源www| 香蕉视频在线精品视频| 欧美精品久久久久久久自慰| 五月丁香六月激情综合在线视频| 99在线精品视频高潮喷吹| 亚洲国产av美女网站| 99久久国语露脸精品国产| 亚洲乱码日产精品bd在| 麻豆果冻传媒2021精品传媒一区| 亚洲va欧美va天堂v国产综合 | 综合五月激情二区视频| 国产激情无码一区二区| 伊人精品成人久久综合| 国产大陆亚洲精品国产|