在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Delta-sarcoglycan (Sgcd)

  • 中文名稱:
    小鼠Sgcd重組蛋白
  • 貨號:
    CSB-CF021184MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Sgcd
  • Uniprot No.:
  • 別名:
    Sgcd; Delta-sarcoglycan; Delta-SG; 35 kDa dystrophin-associated glycoprotein; 35DAG
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-289
  • 氨基酸序列
    MPQEQYSHHRSTMPSSEGPHIYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIKSRPGNALYFKSARNVTVNILNDQTKVLTQLVTGPKAVEAYGKRFEVKTVSGKLLFSADDSEVVVGAERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNMEAICRSELRLESKDGEIKLDAAKIKLPRLPRGSYTPTGTRQKVFEVCVCANGRLFLSQAGTGSTCQINTSVCL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • 基因功能參考文獻:
    1. Collectively, these results confirm and extend understanding of a functional role for the dystrophin-glycoprotein complex in the contractile properties of airway smooth muscle and demonstrate that this results in altered lung function in vivo. PMID: 25692961
    2. Myocardial expression of p.S151A cDNA, similar to intact Sgcd cDNA, restores cardiac function, although not being able to prevent myocardial histopathology in Sgcd-null mice completely. PMID: 23695275
    3. Despite SGC rescue, and contrary to previous observations obtained with WT/mdx chimeras low levels of ESC incorporation were insufficient to produce histological corrections in SGdelta-KO skeletal muscle or heart. PMID: 22328522
    4. This study supports a model where dystrophin, but not the sarcoglycans, protects the cardiac myocyte against mechanical damage. PMID: 21665956
    5. dystrophic phenotype observed in delta-sarcoglycan-null (Sgcd(-/-)) mice and dystrophin mutant mdx mice is dramatically improved by skeletal muscle-specific overexpression of sarcoplasmic reticulum Ca(2+) ATPase 1 (SERCA1) PMID: 21285509
    6. This study demonstrated that the severe cardiac dysfunction in Scgd(-/-) mice at 8 months. PMID: 20934875
    7. delta-SG isoforms may stabilize gamma-SG and microSPN in transverse tubules and sarcoplasmic reticulum membranes and this possible complex may play a role in maintenance of stable level of resting cytosolic calcium concentration in skeletal muscle. PMID: 20638123
    8. Abscence of sarcoglycan delta may be related to pathogenesis of muscular dystrophy. PMID: 19931597
    9. delta- and gamma-sarcoglycan prevent vascular spasm in coronary arteries and in vascular smooth muscle PMID: 14991064
    10. a delta-sarcoglycan isoform is localized at the sarcoplasmic reticulum of mouse skeletal muscle PMID: 16403451
    11. We propose that MDPCs may be the promising progenitor cells in skeletal muscle to treat delta-sarcoglycan complex mutant cardiomyopathy. PMID: 17150187
    12. The S151A delta-sarcoglycan gene mutation acts in a dominant negative manner to produce trafficking defects that disrupt nuclear localization of lamin A/C and emerin, thus linking together two common mechanisms of inherited cardiomyopathy. PMID: 17164264
    13. mdx and sgcd-/- arteries had decreased distensibilities in pressure-diameter tests, mdx arteries exhibiting elevated circumferential stresses, and mdx and sgcd-/- arteries generated elevated axial loads and stresses in axial force-length tests. PMID: 17525297
    14. Steroid treatment causes deterioration of myocardial function in the delta-sarcoglycan-deficient mouse model for dilated cardiomyopathy. PMID: 18495669
    15. These results indicate that mechanical stress is not a primary cause for the loss of other sarcoglycans (SG) when the delta-SG gene is deficient. PMID: 19083155
    16. Sub-physiological sarcoglycan expression plays a critical role in ameliorating muscle disease in mdx mice. PMID: 19131360

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Sarcoglycan beta/delta/gamma/zeta family
  • 組織特異性:
    Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.
  • 數據庫鏈接:


主站蜘蛛池模板: 国产成人综合久久亚洲精品 | 婷婷色香合缴缴情av第三区| 日本天天日噜噜噜| 蜜桃麻豆www久久国产sex| 国产成人久久久精品二区三区| 一本一道久久a久久精品综合| 婷婷五月综合色视频| 国产成人亚洲综合网色欲网| 日日碰日日摸夜夜爽无码| 深爱婷婷国产在线精品av| 精品综合久久久久久888蜜芽| 日本最大色倩网站www| 日日av色欲香天天综合网| 五月婷婷久久草| 国产a∨精品一区二区三区不卡| 日本欧美大码a在线观看| 麻豆果冻精东九一传媒mv| 成人三级视频在线观看一区二区| 欧美成人猛片aaaaaaa| 日本人妻伦在线中文字幕| 又大又粗又爽免费视频a片| 中文字幕日韩一区二区不卡| 久久精品黄aa片一区二区三区 | 国产精品久免费的黄牛仔短裤| 亚洲国产无套无码av电影| 午夜在线观看免费线无码视频| 人妻少妇69式99偷拍| 伊人久久大香线蕉av网站| 国产成av人片在线观看无码| 秋霞影院午夜伦a片欧美| 和岳每晚弄的高潮嗷嗷叫视频| 在线观看国产成人av片| 成人无码专区免费播放三区| 精品无码人妻一区二区三区| 亚洲人成亚洲精品| 精品欧美аv高清免费视频| 已婚少妇美妙人妻系列| 亚洲最大无码中文字幕| 久久精品囯产精品亚洲| 中国女人内谢69xxxx免费视频| 女人被狂躁c到高潮视频|