在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Cystinosin (Ctns)

  • 中文名稱:
    Recombinant Mouse Cystinosin(Ctns)
  • 貨號(hào):
    CSB-CF006174MO
  • 規(guī)格:
  • 來(lái)源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    Ctns
  • Uniprot No.:
  • 別名:
    Ctns; Cystinosin
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度:
    Full length protein
  • 表達(dá)區(qū)域:
    1-367
  • 氨基酸序列
    MRRNWLLILTLFLLMFIEKYESTVSLTAPPTVKLENGSSTNVDITLGHPLNSTLVITFEV TFRSKNLTIVELPDEVIVPRGEKNASFQVTSQNIGQVTVFLHGNHSNQTCPRIRFLVIHS RIVSIINQVIGWIYFMAWSVSFYPQVIQNWRRKSVIGLSFDFLALNLTGFVAYSVFNIGL LWVPYIQEEFLLKYPNGVNPVDSNDAFFSLHAVALTLIVILQCCLYERGNQRVSWPSIGF LVLAWLFVLVTMIVAAVGITTWLQFLFCFSYIKLIITLIKYFPQAYMNFYYKSTKGWSIG GVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFTIFFDVVFFIQHFYLYRKK PGYDQLN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity.
  • 基因功能參考文獻(xiàn):
    1. LAMP2A trafficking is regulated by cystinosin, Rab11, and RILP and that CMA up-regulation is a potential clinically relevant mechanism to increase cell survival in cystinosis. PMID: 28465352
    2. Data indicate that hematopoietic stem cell (HSC) transplantation in cystinosin knockout (Ctns-/-) thyroid drastically decreased cystine accumulation and normalized the thyroid-stimulating hormone level. PMID: 26812160
    3. Cells and tissues lacking CTNS expression are characterized by increased autophagosome numbers, but functional macroautophagic flux. PMID: 25586965
    4. The onset of Fanconi syndrome in knockout mice is between 3 and 6 months of age with structural and functional changes in proximal tubular cells (PTCs), with focus on endocytosis of ultrafiltrated disulfide-rich proteins as a key source of cystine. PMID: 24525030
    5. The Ctns(-/-) mouse model generated on C57BL/6 background is not suitable for clarifying the pathogenesis of male infertility in cystinosis. PMID: 22578532
    6. Deletion of cystinosis gene (Ctns) causes corneal cystine crystals formation, neovascularization and scarring in the cornea of ctns transgenic mice mimicking cystinosis in humans. PMID: 21897743
    7. CTNS has a role in proper functioning of the retina and bones, and in mouse behavior PMID: 12370309
    8. Temporospatial pattern of cystine accumulation in Ctns-/- mice parallels that of patients and validates the mice as a model for the ocular anomalies of cystinosis. PMID: 17597652
    9. Data provide the proof-of-concept that gene transfer is feasible for correcting defective lysosomal transport, but suggest that, in the case of cystinosis, it could be preventive but not curative in some tissues. PMID: 18578013

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Lysosome membrane; Multi-pass membrane protein. Melanosome membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Cystinosin family
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 黑人巨大白妞出浆| 亚洲精品久久av无码麻| 国产女厕所盗摄老师厕所嘘嘘| 欧美又黄又大又爽a片三年片| 在线观看午夜亚洲一区| 隔壁邻居是巨爆乳寡妇| 亚洲精品国偷拍自产在线观看蜜臀| 国产精品无码mv在线观看| 亚洲国产99精品国自产拍| 2020最新无码国产在线观看| 又爽又黄无遮挡高潮视频网站| 自拍偷在线精品自拍偷免费| 伊人久久大香线蕉av色婷婷色 | 午夜伦4480yy私人影院| 国产精品白丝av网站| 国产中的精品av一区二区 | 无码人妻少妇精品无码专区漫画 | 国产精品久久久久久久久久久免费看 | 色窝窝无码一区二区三区色欲| 国产午夜亚洲精品不卡下载| 一边摸一边做爽的视频17国产 | 色国产精品一区在线观看| 久久精品人人槡人妻人| 国产精品无码久久av不卡| 国产av天堂亚洲国产av麻豆| 亚洲欭美日韩颜射在线二| 99精品国产兔费观看久久99| 国产精品乱子伦xxxx| 人妻无码精品久久亚瑟影视 | 亚洲乱亚洲乱妇| 理论片午午伦夜理片影院| 国产尤物精品自在拍视频首页| 激情久久av一区av二区av三区| 天堂а√8在线最新版在线| 亚洲风情亚aⅴ在线发布| 日韩免费特黄一二三区| 久久国产免费观看精品3| 色 综合 欧美 亚洲 国产| 国产精品十八禁在线观看| 欧美日韩一区二区成人午夜电影| 99久久久无码国产精品免费|