在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Claudin-6 (Cldn6)-VLPs (Active)

In Stock
  • 貨號:
    CSB-MP3347MO
  • 規格:
    ¥4000
  • 圖片:
    • CSB-MP3347MO is detected by Mouse anti-6*His monoclonal antibody.
    • Activity
      Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/ml can bind Anti-CLDN6/9 recombinant antibody(CSB-RA005508MA1HU). The EC50 is 4.027-6.270 ng/mL.The VLPs (CSB-MP3838) is negative control. Biological Activity Assay
    • Activity
      Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/ml can bind Anti-CLDN6/9 recombinant antibody(CSB-RA005508MA3HU). The EC50 is 7.349-12.12 ng/mL.The VLPs (CSB-MP3838) is negative control. Biological Activity Assay
    • The purity of VLPs was greater than 95% as determined by SEC-HPLC
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SEC-HPLC.
  • 內毒素:
    Less than 1.0 EU/ug as determined by LAL method.
  • 生物活性:
    ①Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody(CSB-RA005508MA1HU). The EC50 is 4.027-6.270 ng/mL.The VLPs (CSB-MP3838) is negative control. ②Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody(CSB-RA005508MA3HU). The EC50 is 7.349-12.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Claudin-6; Skullin; Cldn6
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 分子量:
    24.8 kDa
  • 表達區域:
    1-219aa
  • 氨基酸序列
    MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVVTLLIVLLGLLVYLAGAKCTTCVEDRNSKSRLVLISGIIFVISGVLTLIPVCWTAHSIIQDFYNPLVADAQKRELGASLYLGWAASGLLLLGGGLLCCACSSGGTQGPRHYMACYSTSVPHSRGPSEYPTKNYV
  • 蛋白標簽:
    C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions)
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻:
    1. Cldn6 was markedly decreased in the lungs of mice exposed to acute tobacco sm PMID: 27982694
    2. These data reveal captivating information suggesting a role for Cldn6 in lungs exposed to tobacco smoke and suggest that further research is necessary in order to fully explain roles for tight junctional components such as Cldn6 PMID: 27763528
    3. Over-expression of Claudin 6 during embryogenesis delays lung morphogenesis. PMID: 26198145
    4. Cldn6 is expressed by pulmonary epithelium during lung organogenesis. PMID: 24970044
    5. The Inv-Cldn6-CDelta206 transgenic mice displayed a developmental delay in epidermal permeability barrier formation, as shown by the expression of keratins and Cldns, and by X-Gal penetration assays. PMID: 20106878
    6. the normally robust injury response mechanism of the epidermis is lost in the aging Involucrin-Cldn6-CDelta196 transgenic epidermis PMID: 19915705
    7. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. PMID: 11923212
    8. Cldn6 plays a role in the differentiation processes of the epidermis and hair follicle PMID: 15908185
    9. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 ce PMID: 16306693
    10. developmentally expressed claudin isoforms include claudin 6, claudin 9, and claudin 13 PMID: 16774906
    11. Results demonstrate that the overexpression of a tail truncation mutant of claudin 6 (Cldn6) mislocalizes Cldn6 and other Cldn proteins to the cytoplasm and triggers a postnatal increase in proliferation and aberrant differentiation of the epidermis. PMID: 16847338
    12. Tight junctions containing claudin 6 are essential for blastocyst formation in preimplantation mouse embryos PMID: 17980358
    13. A lineage analysis of the fate of Cldn6-expressing embryonic endoderm cells is relevant to the development of the pancreas, lung, and liver. PMID: 18213590
    14. Expression analysis in mice has shown that Claudin-6 is one of the few genes that allows for the targeting of the definitive endoderm throughout the entire anterior-posterior axis, before and after gut tube patterning. PMID: 18213590

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Claudin family
  • 組織特異性:
    Expressed mostly in embryonic tissues.
  • 數據庫鏈接:


主站蜘蛛池模板: 国产又色又爽又刺激在线观看| 中国国产野外1级毛片视频| 久久视频这里只精品| 永久免费无码av在线网站| 综合色就爱涩涩涩综合婷婷 | 少妇激情一区二区三区视频| 欧美成人午夜精品久久久| 国产成人无码视频一区二区三区| 爆乳熟妇一区二区三区| 蜜桃av久久久一区二区三区麻豆| 久久天天躁狠狠躁夜夜2020老熟妇 | 亚洲国产精品久久一线不卡| 热re99久久精品国产66热| 国产精品色无码av在线观看| 四虎精品国产永久在线观看| 好爽好舒服要高潮了视频| 国产精品久久久久久久久久久免费看| 扒开双腿吃奶呻吟做受视频 | 中文字幕久久综合伊人| 热の综合热の国产热の潮在线| 成人av无码国产在线观看| 国产精品xxx在线| 日韩在线永久免费播放| 国产日韩综合av在线观看一区| 亚洲日本一区二区三区在线| 国产精品爽爽久久久久久蜜臀| 亚洲国产婷婷香蕉久久久久久| 亚洲精品乱码一区二区三区| 日韩不卡1卡2卡三卡2021精品推荐| 国产精品盗摄!偷窥盗摄| 女的被弄到高潮娇喘喷水视频| 午夜av亚洲一码二中文字幕青青| 一区二区三区四区在线 | 欧洲| 亚洲人成网线在线播放va蜜芽| 欧美一区二区| 日本妇人成熟免费视频| 国内精品视频一区二区八戒| 国产在线视频www色| 国产又大又粗又爽的毛片| 国产成人最新三级在线视频| 欧美日韩无线码在线观看|