在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Claudin-1 (Cldn1)

  • 中文名稱:
    Recombinant Mouse Claudin-1(Cldn1)
  • 貨號(hào):
    CSB-CF005490MO
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Cldn1; Claudin-1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full length protein
  • 表達(dá)區(qū)域:
    1-211
  • 氨基酸序列
    MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTG QIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAV IGGIIFLISGLATLVATAWYGNRIVQEFYDPLTPINARYEFGQALFTGWAAASLCLLGGV LLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.
  • 基因功能參考文獻(xiàn):
    1. Taken together, these results demonstrate that BTZ-induced claudin 1 expression may be a valuable therapeutic approach for AD. PMID: 28859979
    2. Results suggest that TLR4-dependent claudin-1 internalization and secondary anion secretion contribute to irinotecan-induced diarrhea. PMID: 27550942
    3. The data suggested that miR-29a may regulate tumor growth and migration by targeting CLDN1. PMID: 28342862
    4. Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (Msx) genes Msx1d/d/Msx2d/d uteri. PMID: 26667042
    5. Cldn-1 is a positive regulator of osteoblast proliferation and differentiation. PMID: 25479235
    6. We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions. PMID: 25340345
    7. MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease. PMID: 25277410
    8. Occludin and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis. PMID: 24845399
    9. regulates intestinal epithelial homeostasis via regulation of Notch-signalling PMID: 23766441
    10. Downregulation of Sirt1 and upregulation of the tight junction protein Claudin-1 by SIRT1-mediated epigenetic regulation in podocytes contributed to albuminuria. PMID: 24141423
    11. Cldn1(-/-) mice exhibited the abnormal stratum granulosum formation and stratum corneum barrier defects. PMID: 23433550
    12. miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1 PMID: 23523916
    13. Claudin-1 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, dark cell area. PMID: 14698084
    14. we identified Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2 macrophages PMID: 22268650
    15. Mouse CLDN1 (mCLDN1) supported HCV genotype 2a infection with only moderate efficiency. indicating CLDN1 also contributes to the restricted species tropism of HCV. CLDN1 also contributes to the restricted species tropism of HCV. PMID: 19889758
    16. dynamic behavior of paired strands of this protein in cell membranes PMID: 12651952
    17. Thr203 of claudin-1 is required to enhance the barrier function of claudin-1-based tight junctions, probably via its phosphorylation and subsequent integration into tight junctions. PMID: 15051488
    18. In the absence of follicle-stimulating hormone receptor signaling, claudin-1 decreases in ovarian surface epithelium and tumors in comparison to wild type. PMID: 17217615
    19. Claudin-1 was located in murine Langerhans cells (LC) in epidermis. TGF-beta stimulated accumulation of claudin-1 mRNA and protein when added to cultured bone marrow cells. Claudin-1 may have a function in adhesion and migration of LC. PMID: 17508021
    20. Cldn1 is localized in the epidermis and nail and in the dorsal surface of the tongue and glandular compartment of the stomach but is absent from the oral mucosa and the keratinized compartment of the stomach. PMID: 17828607
    21. Nectin plays a novel role in the co-localization of JAM and claudin at the same cell-cell adhesion membrane domains. PMID: 18547333
    22. Claudin-1 is a p63 target gene with a crucial role in epithelial development PMID: 18648642
    23. The induction of tight-junction protein claudin-1 and paracellular permeability during the differentiation of osteoblast-like MC3T3-E1 cells after treatment with IGF-I is regulated via a MAP-kinase pathway, but not with respect to gap junctions. PMID: 18855015
    24. This study investigated whether the conserved "dFynPl" sequence is essential for claudin-1, continuous strand-forming claudin, to form TJ strands PMID: 19234713
    25. LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and the turnover of tight junctions is regulated by ubiquitylation. PMID: 19295125

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.
  • 蛋白家族:
    Claudin family
  • 組織特異性:
    Detected in epidermis and liver (at protein level). Widely expressed, with highest levels in liver and kidney.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国色天香中文字幕在线视频| 亚洲精品无码久久久影院相关影片| 精品国产福利久久久| 女人19水真多免费毛片| 影音先锋每日av色资源站| 又粗又大又硬又长又爽| 性生交大片免费看l| 亚洲中文字幕永久在线不卡| 亚洲aⅴ在线无码播放毛片一线天| 国产综合18久久久久久| 国产香蕉尹人视频在线| 日本老妇人乱xxy| 国产传媒麻豆剧精品av国产| 欧美40老熟妇色xxxxx| 色噜噜狠狠狠狠色综合久一| 日本最大色倩网站www| 久久综合给合久久狠狠狠97色69| 色欲视频综合免费天天| 九九99无码精品视频在线观看| 久久久久久久精品成人热色戒汤唯| 桃花色综合影院| 丰满少妇作爱视频免费观看| 亚洲大成色www永久网站动图| 国产免费久久精品99reswag | 亚洲一区二区三区| 久久五月精品中文字幕| 久久精品国产精品亚洲下载| 麻豆专媒体一区二区| 日韩精品无码熟人妻视频| 日韩精品久久无码人妻中文字幕| 亚洲国产一区二区波多野结衣| 国产午睡沙发被弄醒完整版| 国产精品久久久久久久久久妞妞 | 在线成人www免费观看视频| 少妇把腿扒开让我爽爽视频| 色婷婷我要去我去也| 国产av无码专区影视| 黄页网址大全免费观看| 日本免费人成视频播放| 午夜男女爽爽影院免费视频| 精品丝袜国产自在线拍小草|