在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Bax inhibitor 1 (Tmbim6)

  • 中文名稱:
    小鼠Tmbim6重組蛋白
  • 貨號:
    CSB-CF887505MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Tmbim6
  • Uniprot No.:
  • 別名:
    Tmbim6; Tegt; Bax inhibitor 1; BI-1; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-237
  • 氨基酸序列
    MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLS ALGSLALMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALELCIAVNPSILPTAFMG TAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLYLGLLV MCGFVLFDTQLIIEKAEHGDKDYIWHCVDLFLDFVTLFRKLMLILAFNEKDKKKEKK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation.
  • 基因功能參考文獻:
    1. BI-1 protects against obesity-induced hepatic insulin resistance by regulating CYP2E1 activity and reactive oxygen species production. PMID: 27576594
    2. BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation. PMID: 27297735
    3. BI-1 has a major role in the functioning of the adaptive immune system by regulating intracellular Ca(2+) homeostasis in lymphocytes. PMID: 26470731
    4. An endogenous protective role of BI-1 under conditions of chronic mild stress. PMID: 24292328
    5. Results highlight the regulatory role of BI-1 in idiopathic pulmonary fibrosis. PMID: 24625972
    6. BI-1-induced ERK1/2 activation plays an important role in the modulation of intracellular reactive oxygen species generation and apoptotic cell death and may also affect autoimmune response. PMID: 22309999
    7. The results reveal BI-1 as a novel autophagy regulator that bridges Ca(2) signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress. PMID: 22588718
    8. BI-1-mediated enhancement of lysosomal activity regulates P450 2E1 expression and resultant ROS accumulation PMID: 22230367
    9. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. PMID: 22128171
    10. highly maintained lysosomal activity may be one of the mechanisms by which BI-1 exerts its regulatory effects on the ER stress response and cell death. PMID: 21586565
    11. A critical role of BI-1 as a stress integrator that modulates autophagy levels and other interconnected homeostatic processes. PMID: 21926971
    12. BI-1 reduces endoplasmic reticulum (ER) stress and provides protection from acute brain injury via modulation of several ER-associated functions, including unfolded protein response signaling. PMID: 21075086
    13. BI-1 may confer affective resiliency in multiple animal models of depression and anhedonia PMID: 21718971
    14. NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection. PMID: 20133763
    15. Data show that BI-1 increased actin polymerization and cell adhesion through Ca2+ regulation and actin interaction. PMID: 20123969
    16. BI-1 is a critical regulator of ER stress responses in the development of obesity-associated insulin resistance PMID: 19996103
    17. BI-1 provides endogenous protection of liver and kidney from endoplasmic reticulum stress and ischemia-reperfusion injury. PMID: 16478805
    18. BI-1 and Bcl-X(L) operate downstream of or parallel to Bax/Bak PMID: 18299329
    19. Discusses cloning of rat testis enhanced gene transcript and identification of its homolog in mouse. PMID: 8012111
    20. Discusses cloning of human testis enhanced gene transcript and its conservation in mouse and rat. PMID: 8530040

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    BI1 family
  • 組織特異性:
    Highly abundant in adult testis.
  • 數據庫鏈接:


主站蜘蛛池模板: 九九热爱视频精品视频| 五月丁香啪啪激情综合色九色| 国产360激情盗摄全集| 动漫无遮挡h纯肉亚洲资源大片| 亚洲人成网站在线观看69影院| 亚洲欧美国产毛片在线| 国产如狼似虎富婆找强壮黑人| 国产精品久久久久久无码五月| 精品丝袜国产自在线拍小草| 又大又粗弄得我出好多水| 午夜福利视频合集1000| 美女黄频视频大全免费的国内| 无码丰满熟妇bbbbxxx| 亚洲精品国产suv一区88| 国产精品亚洲一区二区无码| 亚洲精品一线二线三线区别大吗| 国产精品天天狠天天看| 国产艳妇av在线观看果冻传媒| 亚洲卡1卡2卡新区网站| 插插插精品亚洲一区| 偷国产乱人伦偷精品视频| 亚洲人成人网站色www| 亚洲大尺度无码无码专线| 国产成人综合久久免费导航| 老妇女性较大毛片| 99精品无码一区二区| 国产在线午夜不卡精品影院| 宝贝腿开大点我添添公视频免费| 久久综合九色综合久99| 香蕉免费一区二区三区在| 18成禁人视频免费| 欧美日韩一区二区三区在线观看视频 | 精品无码av一区二区三区| 国产亚洲一卡2卡3卡4卡网站| 男女免费观看在线爽爽爽视频| 97久久精品人人澡人人爽| 免费无码午夜福利片| 忘忧草影院在线www韩国日本| 国产精品毛片久久久久久久| 又黄又爽又色的视频| 日韩精品专区在线影院重磅|