在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Atrial natriuretic peptide receptor 3 (Npr3)

  • 中文名稱:
    小鼠Npr3重組蛋白
  • 貨號:
    CSB-CF016025MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Npr3; Atrial natriuretic peptide receptor 3; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C; EF-2
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    41-536
  • 氨基酸序列
    EALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWRRGDKHDSEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFQMRSNVKYPWGPLKLRLDETRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNQQEESNIGKHRELREDSIRSHFSVA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
  • 基因功能參考文獻:
    1. this study shows that sensory axon bifurcation is insensitive to increases of C-type natriuretic peptide induced cyclic GMP levels and the guanylate cyclase receptor Npr3 does not have an important scavenging function in this axonal system. PMID: 27740716
    2. A model of kyphosis due to a novel NPR3 Tyr209Asn mutation is established. PMID: 27959934
    3. Npr3 is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP signaling in fracture repair, especially in bone remodeling stage. PMID: 25860030
    4. NPR-C is required to control DNA damage-induced p53 levels to maintain embryonic stem cell self-renewal. PMID: 21846177
    5. A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies Npr3 as novel candidate obesity genes. PMID: 21915269
    6. Upregulation of NPR-C mRNA in the kidney and heart of eNOS knockout mice. PMID: 20403400
    7. CNP has negative chronotropic effect on heart rate, and this effect is mediated by selectively activating NPR-C and reducing L-type Ca2+ current through coupling to Gi protein. PMID: 14704228
    8. discussion of neuronal regulation and function of natriuretic peptide receptor C [review] PMID: 15911073

    顯示更多

    收起更多

  • 相關疾病:
    Defects in Npr3 are the cause of a number of skeletal-overgrowth phenotypes, Longjohn (Lgj), Longjohn-2J (Lgj-2J) and Strigosus (Stri). These are all recessive conditions characterized by an elongated body, thoracic kyphosis, arachnodactyly, and sacral and/or tail kinks, but no significant changes in craniofacial structures (PubMed:10468599).
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    ANF receptor family
  • 數據庫鏈接:


主站蜘蛛池模板: 在线永久无码不卡av| 婷婷五月俺也去人妻| 国产免费人成网站x8x8| 久久久久av无码免费网| 免费的黄网站在线观看| 白丝美女被狂躁免费视频网站| 四虎永久在线精品884aa| 在线精品自偷自拍无码中文| 天躁夜夜躁狼狠躁| 亚洲人成在线观看网站不卡| 久久久久久无码精品人妻a片软件 999久久久精品国产消防器材 | 色老头精品午夜福利视频| 少妇被又大又粗又爽毛片久久黑人 | 伊人情人综合网| 日韩精品极品视频在线观看免费 | 天天做天天爱夜夜爽| 国产成人亚洲高清一区| 高清无码爆乳潮喷在线观看 | 国产成人麻豆亚洲综合无码精品| 免费刺激性视频大片区| 18禁裸男晨勃露j毛网站| 国产成人av一区二区在线观看| 亚洲啪啪综合av一区| 久久综合九色综合欧美婷婷| 成在人线无码aⅴ免费视频| 中文字幕亚洲无线码| 国精品午夜福利视频不卡| 2021少妇久久久久久久久久| 99精品人妻少妇一区二区| 末发育娇小性色xxxxx视频| 玩弄少妇的肉体k8经典| 亚洲另类激情专区小说| 真人性囗交69视频| 冲田杏梨av一区二区三区| 亚洲色成人一区二区三区| 好了av四色综合无码| 国产精品无码电影在线观看| 亚洲麻豆av成本人无码网站| 野花社区在线观看视频| 国产农村妇女aaaaa视频| 成年女人看片永久免费视频|