在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Adrenocorticotropic hormone receptor (Mc2r)

Recombinant Mouse Adrenocorticotropic hormone receptor (Mc2r)

  • 中文名稱：
    小鼠Mc2r重組蛋白
  • 貨號(hào)：
    CSB-CF723737MO
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Mc2r; Acthr; Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-296
  • 氨基酸序列
    MKHIINSYEHTNDTARNNSDCPDVVLPEEIFFTISVIGILENLIVLLAVIKNKNLQSPMY FFICSLAISDMLGSLYKILENILIMFRNMGYLKPRGSFESTADDIIDCMFILSLLGSIFS LSVIAADRYITIFHALQYHSIVTMRRTIITLTIIWMFCTGSGITMVIFSHHIPTVLTFTS LFPLMLVFILCLYIHMFLLARSHARKISTLPRTNMKGAMTLTILLGVFIFCWAPFVLHVL LMTFCPNNPYCVCYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKRMLFCNRY
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
  • 基因功能參考文獻(xiàn)：
    1. JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands. PMID: 28146118
    2. Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice. PMID: 24742195
    3. MC2R plays an important role for regular lipolytic function and lipid composition in 3T3-L1 adipocytes. PMID: 22723268
    4. Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells. PMID: 22306084
    5. melanocortin 2 receptor and melanocortin 5 receptor are lipolytic mediators in differentiated 3T3-L1 adipocytes PMID: 21616121
    6. MC2R+/- pups delivered from MC2R-/- females crossed with MC2R+/+ males mice thrived poorly with MC2R-/- mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R-/- females are poor mothers or cannot nurse. PMID: 21303938
    7. The promoter activity of Mc2r is activated by FOXL2 in a dose-dependent manner; transcriptional activity of Mc2r is up-regulated by synergistic interaction of FOXL2 and NR5A1. PMID: 20650879
    8. MC2R in Y1 cells internalizes by a G protein coupled receptor kinase dependent clathrin-coated pit mechanism. PMID: 12530627
    9. Data show that adrenocorticotrophic hormone resistance in tumor cell mutants is associated with a base change polymorphism in the steroidogenic factor 1 gene. PMID: 12851310
    10. Novel 135-bp exon 1f of ACTH-R gene was located 1.4 kb downstream in genome of exon 1a transcribed in adrenal gland. Promoter region flanking to exon 1f may be essential for adipose tissue; that flanking to exon 1a is specific for the adrenal gland. PMID: 15004405
    11. a novel mechanism for mc2-r transcription, which may have significance in both adrenal and extra-adrenal sites of expression PMID: 15028712
    12. Mc2r expression is associated with a less aggressive tumor phenotype and anti-proliferative effects can be amplified through stimulation with physiological doses of ACTH. PMID: 16131607
    13. A CCAAT/enhancer-binding protein binding site, 87 bp upstream of the transcriptional initiation site, is necessary for the activity of Mc2R promoter. PMID: 16997835
    14. MC2-R gene is regulated both transcriptionally and post-transcriptionally during adipogenesis PMID: 17170082
    15. MC2R is required for postnatal adrenal development and adrenal steroidogenesis and that MC2R KO mice provide a useful animal model by which to study familial glucocorticoid deficiency PMID: 17989225
    16. The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line. PMID: 18162519
    17. MRAP not only facilitates MC2 receptor trafficking but also allows properly localized receptor to bind ACTH and consequently signal. PMID: 18981183
    18. Results describe the phenotype of mice deficient in melanocortin 2 receptor on a B6/Balbc mix background. PMID: 19022343
    19. The results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor but disrupting dimerization and surface localization of MC5 receptor. PMID: 19535343

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 无码人妻精品一区二区三18禁| 国产在线看片免费视频 | 日韩午夜理论免费tv影院| 2021国产成人精品久久| 在线观看免费人成视频| 一本大道久久久久精品嫩草| 亚洲gv猛男gv无码男同 | h人成在线看免费视频| 欧美性猛交xxxx乱大交蜜桃| 337p粉嫩大胆色噜噜噜| 国产婷婷色一区二区三区在线| 精品欧美h无遮挡在线看中文| 中日精品无码一本二本三本| 欧美变态口味重另类在线视频| 国产大屁股喷水视频在线观看| 中文在线а√在线天堂中文| 99精品国产在热久久无毒| 亚洲欧美日韩综合av| 风间由美性色一区二区三区| 国产成人av无码精品天堂| 2019久久视频这里有精品15| 综合色就爱涩涩涩综合婷婷| 欧洲美女粗暴牲交免费观看| 国产无套内射久久久国产| 欧美黑人粗大xxxxbbbb| 欧美乱妇xxxxxbbbbb| 五月综合激情婷婷六月色窝| 国语精品一区二区三区| 狠狠色噜噜狼狼狼色综合久| 国产日产欧产精品精品app| 亚洲精品一卡2卡三卡4卡| 日本熟妇浓毛| 国产日产欧产精品精品| 亚洲第一天堂无码专区| 天干夜天干天天天爽视频| 国内露脸中年夫妇交换| 亚洲成av人片不卡无码久久| 亚洲国产精品无码专区影院| 激情 小说 亚洲 图片 伦| 亚洲精品一区二区三区婷婷月| 久久青青草原国产最新片完整|