在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human herpesvirus 1 Envelope glycoprotein K (gK)

  • 中文名稱:
    Recombinant Human herpesvirus 1 Envelope glycoprotein K(gK)
  • 貨號:
    CSB-CF300097HWY
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    gK; UL53; Envelope glycoprotein K; Syncytial protein
  • 種屬:
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    31-338
  • 氨基酸序列
    ASPLHRCIYAVRPTGTNNDTALVWMKMNQTLLFLGAPTHPPNGGWRNHAHICYANLIAGR VVPFQVPPDAMNRRIMNVHEAVNCLETLWYTRVRLVVVGWFLYLAFVALHQRRCMFGVVS PAHKMVAPATYLLNYAGRIVSSVFLQYPYTKITRLLCELSVQRQNLVQLFETDPVTFLYH RPAIGVIVGCELMLRFVAVGLIVGTAFISRGACAITYPLFLTITTWCFVSTIGLTELYCI LRRGPAPKNADKAAAPGRSKGLSGVCGRCCSIILSGIAVRLCYIAVVAGVVLVALHYEQE IQRRLFDV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Glycoprotein that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes. Also plays a role, together with gB, in virus-induced cell-to-cell fusion (syncytia formation). Seems to block fusion of virions with infected-cell membranes.
  • 基因功能參考文獻:
    1. a deletion in the amino terminus of glycoprotein K (gK) inhibits gB binding to Akt-1(S473), the release of intracellular calcium, and virus entry via fusion of the viral envelope with cellular plasma membranes. PMID: 29321326
    2. This work suggests that the amino terminus of gK is a critical determinant for entry into neuronal axons and may serve similar conserved functions for other alphaherpesviruses. PMID: 26656706
    3. Taken together, these results strongly suggest that the 8mer peptide (ITAYGLVL) within the signal sequence of gK promotes cell surface expression of gK in infected cells and ocular pathogenesis in infected mice. PMID: 25505072
    4. We demonstrate a novel link between gK exacerbation of CS and HSV-1 receptors, suggesting a gK-induced molecular route for the pathogenesis as well as selective advantage of these entry routes for the pathogen during latency-reactivation cycle. PMID: 24667863
    5. The amino terminus of herpes simplex virus 1 gK is functionally and physically associated with the gB-PILRalpha protein complex and regulates membrane fusion of the viral envelope with cellular membranes during virus entry. PMID: 23302878
    6. gK is a critical determinant for neuronal infection and transmission. PMID: 22829677
    7. required for gB mediated virus induced cell fusion but does not function redundantly with gK and UL20p in membrane fusion during virion de-envelopment at the outer nuclear lamellae. PMID: 15596825
    8. These results strongly suggest that increased gK levels promote eye disease and chronic infection in infected mice. PMID: 17898051
    9. These results show that UL20p domains required for UL20p and gK intracellular transport and TGN localization can be functionally segregated from domains involved in infectious virus production and virus-induced cell fusion. PMID: 17996071
    10. These data show that the amino terminus of gK modulates gB-mediated virus-induced cell fusion and virion egress. PMID: 19793812

    顯示更多

    收起更多

  • 亞細胞定位:
    Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with UL20 to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Cell surface expression of gK is required for virus-induced cell-to-cell fusion. Likely not present in extracellular virions.
  • 蛋白家族:
    Alphaherpesvirinae glycoprotein K family
  • 數據庫鏈接:

    KEGG: vg:2703425



主站蜘蛛池模板: 国产极品美女到高潮| 男女啪啦啦超猛烈动态图| 免费做爰猛烈吃奶摸视频在线观看| 国产精品麻豆欧美日韩ww| 成人性生交大片免费看| 午夜尤物禁止18点击进入| 奇米777狠狠色噜噜狠狠狠| 2021国产精品午夜久久| 国产精品.xx视频.xxtv| 亚洲鲁丝片一区二区三区| 久久久久久久岛国免费观看 | 99久久国产露脸精品竹菊传媒| 少妇粗大进出白浆嘿嘿视频| 伊人久久大香线蕉av一区| 99re久久资源最新地址| 香蕉在线 亚洲 欧美 专区| 日韩毛片免费无码无毒视频观看| 怡红院免费的全部视频| 西西人体大胆啪啪实拍| 日本特黄aaaaaa大片| 欧美成人一区二区三区片免费| 亚洲精品久久久久久下一站| 夜夜躁狠狠躁日日躁202| 动漫精品中文无码卡通动漫| 内射囯产旡码丰满少妇| 精品性高朝久久久久久久| 亚洲一卡2卡三卡4卡国色天香| 日韩人妻无码一区二区三区俄罗斯| 久久精品国产丝袜人妻| 日韩人妻精品一区二区三区视频| 伊人久久大香线蕉aⅴ色| 国产精品久久久久久久久久直播 | 日韩a毛片免费观看| 国产精品欧美成人| 国产美女牲交视频| 亚洲精品国产熟女久久久| 日本强伦姧人妻久久影片| 极品美女扒开粉嫩小泬| 福利姬液液酱喷水| 新版资源天堂中文| 无码人妻在线一区二区三区免费|