在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human UDP-glucuronosyltransferase 1A3 (UGT1A3)

  • 中文名稱:
    人UGT1A3重組蛋白
  • 貨號:
    CSB-CF025576HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    UGT1A3
  • Uniprot No.:
  • 別名:
    UGT1A3; GNT1; UGT1; UDP-glucuronosyltransferase 1A3; UGT1A3; UDP-glucuronosyltransferase 1-3; UDPGT 1-3; UGT1*3; UGT1-03; UGT1.3; UDP-glucuronosyltransferase 1-C; UGT-1C; UGT1C; UDP-glucuronosyltransferase 1A isoform 3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區(qū)域:
    29-534
  • 氨基酸序列
    GKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II.; Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
  • 基因功能參考文獻:
    1. Increased UGT1A3 expression is associated with pancreatic cancer. PMID: 25743847
    2. Transcriptional regulation of the human bile acid and xenobiotic UGT1A3 by its substrate CDCA and FXR is shown PMID: 20189675
    3. The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver. PMID: 19889628
    4. six UGT 1A3 polymorphisms in the Japanese population were shown to have different levels of activity PMID: 14986168
    5. established the genetic mechanisms that might contribute to individual variation in UGT1A3 expression and activity PMID: 17558304
    6. These data demonstrate xenobiotic induced regulation of the UGT1A3 gene by the aryl hydrocarbon receptor, which shows genetic variability PMID: 18677463

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族:
    UDP-glycosyltransferase family
  • 組織特異性:
    [Isoform 1]: Expressed in liver, kidney, colon, esophagus and small intestine.; [Isoform 2]: Expressed in liver, kidney and colon. Not expressed in esophagus and small intestine.
  • 數據庫鏈接:

    HGNC: 12535

    OMIM: 191740

    KEGG: hsa:54659

    STRING: 9606.ENSP00000418532

    UniGene: Hs.554822



主站蜘蛛池模板: 亚洲成av人片在线观看高清| 亚洲欧美日韩在线一区| 好爽好黄的视频| 精品少妇一区二区三区免费观| 国产免费久久精品99久久| 色先锋av影音先锋在线| 亚洲三区在线观看内射后入| 国产国产久热这里只有精品| 国产成人综合久久三区| 伦理片午夜视频在线观看| 国产成人欧美日韩在线电影| 一边摸一边做爽的免费视频日本| 丰满的少妇愉情hd高清果冻传媒| 日日碰狠狠躁久久躁综合小说| 暖暖 在线 日本 免费 中文 | 国产精品亚洲综合久久系列| 欧美特级婬片毛多的少妇| 黄页网站视频免费大全| 国产裸体舞一区二区三区| 国产熟女一区二区三区五月婷| 99精品无码一区二区| 中文字幕乱码人在线视频1区| 国产∨亚洲v天堂无码久久久| 亚瑟av亚洲精品一区二区| 亚洲a∨无码无在线观看| 一本久道高清无码视频| 久久久橹橹橹久久久久高清| 国产亚洲精品合集久久久久 | 久久精品免费一区二区三区| 亚洲精品国偷拍自产在线观看蜜桃 | 超碰aⅴ人人做人人爽| 精品日本免费一区二区三区| 国产丰满人妻一区二区| 亚洲性夜色噜噜噜网站2258kk| 亚洲乱码精品久久久久..| 亚洲夜色噜噜av在线观看| 中文字幕精品久久久久人妻红杏| 久久久久久久精品成人热色戒汤唯| 成人精品视频99在线观看免费| 一群黑人大战亚裔女在线播放| 麻豆国产原创视频在线播放|