在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Tyrosine-protein kinase RYK (RYK)

  • 中文名稱:
    人RYK重組蛋白
  • 貨號:
    CSB-CF020617HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    RYK; JTK5A; Tyrosine-protein kinase RYK
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    26-607
  • 氨基酸序列
    PPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
  • 基因功能參考文獻:
    1. our findings demonstrate that Ryk promotes stem cell-like and tumorigenic features to glioma cells its essential for the maintenance of glioblastoma stem cells PMID: 28086236
    2. Wnt5A/Ryk signaling might provide novel therapeutic strategies to prevent capillary leakage in systemic inflammation and septic shock. PMID: 27159116
    3. results corroborated previous findings of Ryk-mediated Wnt5a effect, and suggested a role for Ror2 in the Wnt5a machinery in glioblastoma PMID: 26596412
    4. Early treatment with HGF/IgG complexes after myocardial ischaemia with reperfusion may rescue tissue through vasoprotection conferred by c-Met and RYK signalling PMID: 26025956
    5. Ryk-intracellular domain pathway may impair FOXO protective activity in mutant polyglutamine neurons, suggesting neurons unable to efficiently maintain function and resist disease from the earliest phases of the pathogenic process in Huntington disease PMID: 24960609
    6. is a candidate wnt5a receptor. PMID: 23748645
    7. The Ryk is important for the Wnt-5a-dependent induction of MMP-2 and invasive activity in glioma-derived cells and that Ryk might have a novel patho-physiological function in adult cancer invasion. PMID: 24621529
    8. RYK and VANGL2 proteins form a complex, whereas RYK also activated RhoA, a downstream effector of PCP signaling. PMID: 22773843
    9. RYK interacts both physically and functionally with the E3 ubiquitin MIB1. MIB1 is sufficient to activate Wnt/CTNNB1 signaling and this activity depends on endogenous RYK. PMID: 21875946
    10. RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6. PMID: 11956217
    11. a missense mutation, 1355G>A, and one rare single nucleotide polymorphisms haplotype may play a role in the development of cleft lip and/or palate in the Vietnamese, and cleft lip and/ or palate and cleft palate only in the Japanese PMID: 16681403
    12. validated occurrence of an unusual TG 3' splice site in intron 7 PMID: 17672918

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family
  • 組織特異性:
    Observed in all the tissues examined.
  • 數據庫鏈接:

    HGNC: 10481

    OMIM: 600524

    KEGG: hsa:6259

    STRING: 9606.ENSP00000296084

    UniGene: Hs.654562



主站蜘蛛池模板: av狼友无码国产在线观看| 欧美日韩综合一区二区三区 | 国产女人好紧好爽| 亚在线观看免费视频入口| 日韩人妻无码精品一专区| 欧美中文字幕无线码视频| 欧美成人午夜免费影院手机在线看| 女人扒开屁股桶爽30分钟| 无码av中文字幕久久专区| 国产亚洲精品久久yy5099| 亚洲中文字幕第一页在线| 国内精品久久人妻互换| av无码一区二区三区| 国产乱人伦偷精品视频免下载| 女人和拘做受全程看视频| 九九久久精品国产免费看小说| 人妻熟妇乱又伦精品视频| 美女视频黄频a免费| 九九视频在线观看视频6 | 亚洲精品成av人片天堂无码| 亚洲综合一区二区三区无码 | 国产精品亚洲成在人线| 成 人 网 站94免费观看| 国产亚洲精品久久久久久老妇小说| 中文天堂国产最新| 亚洲欧洲日本无在线码| 女人爽到高潮视频免费直播| 欧美变态口味重另类在线视频| 97人人模人人爽人人喊网| 大帝av在线一区二区三区| 人妻中出无码一区二区三区 | 国产做a爰片久久毛片a片美国| 国产免费无码一区二区三区| 精品一卡二卡三卡| 亚洲人成无码网www动漫| 国产又色又爽又黄的免费| 兔费看少妇性l交大片免费| 国产欧美va天堂在线电影| 日韩亚洲欧美精品综合| 艳妇乳肉豪妇荡乳| 又湿又黄裸乳漫画无遮挡网站|