在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein G6b (G6B)

  • 中文名稱:
    人MPIG6B重組蛋白
  • 貨號:
    CSB-CF004116HU
  • 說明書:
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    MPIG6B
  • Uniprot No.:
  • 別名:
    MPIG6B; C6orf25; G6B; G6B-B; Megakaryocyte and platelet inhibitory receptor G6b; Protein G6b
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    18-241
  • 氨基酸序列
    NPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner.; Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.
  • 基因功能參考文獻:
    1. G6B seems to act through an autosomal recessive mode of disease transmission in this family and regarded as the gene responsible for the observed hematological disorder. PMID: 27743390
    2. Heparin might modulate the interaction of G6b with its as yet unidentified protein ligand PMID: 15848171
    3. G6B represents a novel inhibitory receptor found on the surface of platelets PMID: 17311996
    4. G6b-B expression is highly restricted to peripheral CD4+ T cells and up-regulated by the IL-4-induced STAT6 pathway, suggesting that G6b-B is involved in regulation of the immune response by CD4+ T cell-mediated and IL-4 induced regulatory mechanisms. PMID: 17678728
    5. G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. PMID: 18955485

    顯示更多

    收起更多

  • 相關疾病:
    Thrombocytopenia, anemia, and myelofibrosis (THAMY)
  • 亞細胞定位:
    [Isoform E]: Endoplasmic reticulum. Golgi apparatus.; [Isoform D]: Endoplasmic reticulum. Golgi apparatus.; [Isoform B]: Cell membrane; Single-pass type I membrane protein.; [Isoform A]: Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Expressed in platelets. Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell l
  • 數據庫鏈接:

    HGNC: 13937

    OMIM: 606520

    KEGG: hsa:80739

    STRING: 9606.ENSP00000364964

    UniGene: Hs.247879



主站蜘蛛池模板: 国产人妖视频一区二区| 性按摩xxxx在线观看| 波多野结衣av一区二区全免费观看| 换脸国产av一区二区三区| 精品久久久久中文字幕加勒比| 国产沙发午睡系列999| 午夜成人性刺激免费视频| 国精产品一区一区三区有限公司 | 日韩欧无码一区二区三区免费不卡 | 人人澡人人澡人人看添| 137肉体摄影日本裸交| 性无码专区无码| 18精品久久久无码午夜福利| 久久久精品2020免费观看| 天天躁夜夜躁狠狠躁2021| 欧美大波少妇在厨房被| 国产精品熟妇一区二区三区四区| 日本人妻丰满熟妇久久久久久| 午夜精品久久久内射近拍高清| 国产模特嫩模私拍视频在线| 女人爽到高潮视频免费直播 | 精品国产av一二三四区| 久久人人爽人人爽人人片av麻烦| 亚洲人成精品久久久久桥| 天天躁日日躁aaaxxⅹ| 性暴力欧美猛交在线播放| 亚洲精品成人区在线观看| 国产av麻豆mag剧集| 亚洲国产欧美国产综合久久| 国内精品视频一区二区八戒| 综合久久给合久久狠狠狠97色| 人妻内射一区二区在线视频 | 手机真实国产乱子伦对白视频| 久久久久无码国产精品一区| 亚洲精品一区二区三区婷婷月| 欧美性xxxx极品hd欧美风情| 中国老熟女重囗味hdxx| 国产亚洲精品久久久久久无几年桃| 极品少妇被黑人白浆直流| 久久精品国自产拍| 中文字幕精品久久久久人妻红杏1 久久久精品日本一区二区三区 |