在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Pro-neuregulin-3, membrane-bound isoform (NRG3)-VLPs

  • 中文名稱:
    Recombinant Human Pro-neuregulin-3, membrane-bound isoform (NRG3)-VLPs
  • 貨號:
    CSB-MP016079HU(A4)
  • 規(guī)格:
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Pro-NRG3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 表達(dá)區(qū)域:
    1-720aa
  • 氨基酸序列
    MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
  • 基因功能參考文獻(xiàn):
    1. No genetic correlation was found between Hirschsprung disease and the three SNPs at NRG3 (rs10748842, rs10883866 and rs6584400) PMID: 28256518
    2. Data show that Williams-Beuren syndrome transcription factor (WSTF) release was mediated by neuregulin-3 (NRG3) following KRASG12V expression in intestinal epithelial cells. PMID: 27449290
    3. These observations encourage investigation of the neurobiology of NRG3 isoforms and highlight inhibition of NRG3 signaling as a potential target for psychiatric treatment development. PMID: 27771971
    4. common variants of GABRG2, RELN and NRG3 and the GABRG2-RELN-PTCH1 interaction networks might confer altered susceptibility to Hirschsprung disease. PMID: 27889765
    5. these data suggest that Nrg3/ErbB4 signaling may be an important factor in nicotine dependence. PMID: 23999525
    6. This study demonstrated that genetic variants in the NRG3 gene play a role in alzheimer disease and revealed that SNPs in the NRG3 genes were more strongly associated with onset age of Alzherimer disease. PMID: 24061483
    7. An association between rs10748842 genotype in neuregulin 3 does not fit a simple inefficiency model of risk association in dorsolateral prefrontal cortex physiology. PMID: 24431462
    8. NRG3 may be a susceptibility gene for Hirschsprung's disease in a Chinese population. PMID: 23315268
    9. Neuregulin 3 rs6584400 genetic carriers are associated with psychotic symptoms and attention performance in schizophrenia. PMID: 22831755
    10. no association of SNPs or haplotypes with risk of schizophrenia in Han Chinese population PMID: 22981155
    11. Our results suggest a role for NRG3 in HSCR etiology and provide insights into the relative contribution of structural variants in both syndromic and non-syndromic HSCR. PMID: 22589734
    12. NRG3 polymorphisms and haplotypes were similar between schizophrenia patients and healthy controls of Korean ethnicity PMID: 21762460
    13. Data show that rs1649942, which is located in the intron region of NM_001165973.1. (NRG3 neuregulin 3), was associated with poorer overall survival in women with optimally debulked tumors. PMID: 21705454
    14. Results suggest that NRG3 may be modulating early attentional processes for perceptual sensitivity and vigilance, with opposite effects in affected individuals and healthy controls. PMID: 20548296
    15. Data show that NRG3 is a schizophrenia susceptibility gene, provide quantitative insight into NRG3 transcription traits in the brain, and reveal a probable mechanistic basis for disease association. PMID: 20713722
    16. The NRG3 protein is a new post-translationally regulated isoform of neuregulin 3 expressed in the developing human central nervous system with a role in oligodendrocyte survival. PMID: 16478787
    17. In transgenic female mice, Nrg3 has a role in the initiation of mammary placodes along the body axis; alterations in morphogenesis and differentiation of other epidermal appendages are also observed, including the hair follicles. PMID: 17880691
    18. NRG3 was expressed in 42% of breast cancers studied. It was preferentially expressed in breast tumors co-expressing EGFR/HER4. PMID: 17962208
    19. The result of tis study supports that the NRG3 gene is a susceptibility gene for schizophrenia. PMID: 18708184
    20. NRG3 is primarily expressed in the central nervous system and is one of three paralogs of NRG1, a gene strongly implicated in SZ. PMID: 19118813
    21. Observational study and genome-wide association study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 18846501

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-3]: Secreted.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
  • 蛋白家族:
    Neuregulin family
  • 組織特異性:
    Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, col
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7999

    OMIM: 605533

    KEGG: hsa:10718

    STRING: 9606.ENSP00000361214

    UniGene: Hs.125119



主站蜘蛛池模板: 国产人妻精品午夜福利免费| www国产亚洲精品久久| 国产高清乱理伦片| 亚洲伊人久久精品酒店| 午夜人妻久久久久久久久| 天天爽天天爽天天爽| 亚洲综合小说专区图片| 成在人线av无码免费看网站直播 | 国产三级精品三级在线观看| 国产国拍亚洲精品av在线| 性生交大片免费看女人按摩摩| 一本一本久久a久久综合精品蜜桃| 999久久久无码国产精品| 亚洲中文字幕无码日韩精品| 国产成人精品优优av| 亚洲精品国产字幕久久不卡| 狠狠亚洲色一日本高清色 | 无码成人精品区在线观看| 欧美大屁股xxxx高跟欧美黑人| 国产男生午夜福利免费网站| 中文字幕无码精品三级在线电影| 免费很黄无遮挡的视频| 爆乳女仆高潮在线观看| 色又黄又爽18禁免费网站现观看| 麻豆果冻精东九一传媒mv| 热re99久久6国产精品免费| 亚洲蜜桃精久久久久久久久久久久| 成人精品视频99在线观看免费 | 久久亚洲精品无码播放| 国产sm鞭打折磨调教视频| 亚洲中文字幕aⅴ天堂| 日日摸天天爽天天爽视频| 日躁夜躁狠狠躁2001| 亚洲成av人在线观看天堂无码| 精品卡1卡2卡三卡免费网站| 久久天天躁夜夜躁狠狠i女人| 国产女同疯狂作爱系列| 福利cosplayh裸体の福利| 日本免费高清线视频免费| 亚洲欧美成人一区二区在线| 亚洲精品亚洲人成在线下载|