在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Potassium channel subfamily K member 10 (KCNK10)

  • 中文名稱:
    人KCNK10重組蛋白
  • 貨號(hào):
    CSB-CF012063HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    KCNK10
  • Uniprot No.:
  • 別名:
    KCNK10; TREK2; Potassium channel subfamily K member 10; Outward rectifying potassium channel protein TREK-2; TREK-2 K(+ channel subunit
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Full length protein
  • 表達(dá)區(qū)域:
    1-538
  • 氨基酸序列
    MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQ GGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVS PQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGG KIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFI LAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLV WFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSV EIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRP NNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYS LDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
  • 基因功能參考文獻(xiàn):
    1. The M2-glycine hinge controls the macroscopic currents of TREK1 channels. PMID: 28676394
    2. This study showed that KCNK10 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders. PMID: 26381449
    3. The selectivity filter conformations of alternative translation initiation isoforms and wild type human TREK-2 are similar in the S4 site and pHo position. PMID: 26271386
    4. Results suggest that the cytosolic C-terminal domain and the bottom of transmembrane segment M2 are required for the 2-aminoethoxydiphenyl borate activation on TREK-2 channels PMID: 25982558
    5. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2. PMID: 26332952
    6. Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation PMID: 25168769
    7. PLD2, but not PLD1, directly binds to the C terminus of TREK1 and TREK2. PMID: 25197053
    8. crystal structures of TREK-2 channel in 2 conformations and in complex with norfluoxetine, a state-dependent blocker of TREK channels; results provide an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli and possible off-target effects of Prozac PMID: 25766236
    9. High TREK-2 expression is associated with epithelial ovarian cancer. PMID: 23479219
    10. Tissue-specific mRNA splicing regulates alternative translation initiation (ATI) of human K(2P)10.1 K+ background channels via recombination of 5 nucleotide motifs. PMID: 21669980
    11. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. PMID: 11897838
    12. Predicts the role of TREK-2 in brain ischemia, memory and other tissues.[REVIEW] PMID: 17689202

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Two pore domain potassium channel (TC 1.A.1.8) family
  • 組織特異性:
    Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6273

    OMIM: 605873

    KEGG: hsa:54207

    STRING: 9606.ENSP00000310568

    UniGene: Hs.560255



主站蜘蛛池模板: 日本特黄aaaaaa片在线观看| 日本肉体xxxx裸交| 东京热人妻无码一区二区av| 女人高潮抽搐潮喷小视频| 2021亚洲国产成a在线| 久久久久久午夜成人影院| 少妇人妻综合久久中文字幕| 国产精品 亚洲一区二区三区| 在线天堂资源www中文| 久久久久久久久无码精品亚洲日韩 | 人妻教师痴汉电车波多野结衣| a 'v片欧美日韩在线| www.一区二区三区在线 | 欧洲| 日韩精品一区二区三区视频| 亚洲乱码中文字幕久久孕妇黑人| av无码天堂一区二区三区| 97国产色伦在色在线播放| 国产一区二区三区小说| 四虎国产精品永久免费网址| 亚洲s色大片在线观看 | 香港三级韩国三级日本三级| 亚洲国产精品无码久久久动漫| 亚洲欧洲中文日韩乱码av| 日本三级吃奶头添泬无码苍井空| 99精品国产再热久久无毒不卡| 永久免费无码网站在线观看个| 国产av无码专区亚洲版综合| 久久人人爽人人爽人人片| 国内精品久久久久精免费| 无遮挡免费高清羞羞视频| 中文字幕人乱码中文字幕| 久久九九精品99国产精品| 国产片免费福利片永久| 亚洲色无码中文字幕yy51999| 久久精品女人天堂av| 国产丰满乱子伦无码专区| 国产在线一区二区香蕉 在线| 极品熟妇大蝴蝶20p| 久久亚洲精品无码爱剪辑| 亚洲精品中文字幕一区二区三区 | 国产精品乱子伦xxxx|