在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Mucolipin-2 (MCOLN2)

  • 中文名稱:
    人MCOLN2重組蛋白
  • 貨號:
    CSB-CF812909HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    MCOLN2
  • Uniprot No.:
  • 別名:
    MCOLN2; Mucolipin-2; Transient receptor potential channel mucolipin 2; TRPML2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-566
  • 氨基酸序列
    MARQPYRFPQARIPERGSGVFRLTVRNAMAHRDSEMKEECLREDLKFYFMSPCEKYRARR QIPWKLGLQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFKHLFLKGYSGTDEDDYSCS VYTQEDAYESIFFAINQYHQLKDITLGTLGYGENEDNRIGLKVCKQHYKKGTMFPSNETL NIDNDVELDCVQLDLQDLSKKPPDWKNSSFFRLEFYRLLQVEISFHLKGIDLQTIHSREL PDCYVFQNTIIFDNKAHSGKIKIYFDSDAKIEECKDLNIFGSTQKNAQYVLVFDAFVIVI CLASLILCTRSIVLALRLRKRFLNFFLEKYKRPVCDTDQWEFINGWYVLVIISDLMTIIG SILKMEIKAKNLTNYDLCSIFLGTSTLLVWVGVIRYLGYFQAYNVLILTMQASLPKVLRF CACAGMIYLGYTFCGWIVLGPYHDKFENLNTVAECLFSLVNGDDMFATFAQIQQKSILVW LFSRLYLYSFISLFIYMILSLFIALITDSYDTIKKFQQNGFPETDLQEFLKECSSKEEYQ KESSAFLSCICCRRRKRSDDHLIPIS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events.
  • 基因功能參考文獻:
    1. High TRPML-2 expression in glioma cells resulted in increased survival and proliferation signaling, suggesting a pro-tumorigenic role played by TRPML-2 in glioma progression. PMID: 27248469
    2. MCOLN2 is transcriptionally activated by PAX5 and has roles in B cell development and function PMID: 25445271
    3. TRPML2 is activated by lowering the extracellular sodium concentration as well as by a subset of small chemical compounds that were previously identified as activators of TRPML3. PMID: 22753890
    4. TRPML 1, 2 and 3 assemblies regulated cell viability and starvation-induced autophagy. PMID: 20736310
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    6. constitutively active h-TRPML2 leads to cell death by causing Ca(2+) overload PMID: 19940139
    7. there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the localization of TRPML3 and not vice versa PMID: 16606612
    8. MCOLN2 traffics through the ADP-ribosylation factor 6 (Arf6)-associated pathway, colocalizing with major histocompatibility protein class I and CD59 in long recycling endosomes. PMID: 17662026
    9. TRPML1 appears to play a novel role in the tissue-specific transcriptional regulation of TRPML2. PMID: 19763610
    10. Data show that TRPMLs form distinct functional channel complexes. PMID: 19885840

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Transient receptor (TC 1.A.4) family, Polycystin subfamily, MCOLN2 sub-subfamily
  • 數據庫鏈接:

    HGNC: 13357

    OMIM: 607399

    KEGG: hsa:255231

    STRING: 9606.ENSP00000359640

    UniGene: Hs.591446



主站蜘蛛池模板: 免费人成在线观看视频播放| 最新精品国偷自产在线美女足| 色无码av在线播放| 性无码专区无码| 高清无码午夜福利视频| 午夜视频久久久久一区| 国产亚洲综合欧美视频| 色婷婷五月综合色啪网| 亚洲精品nv久久久久久久久久 | 一进一出抽搐gif| 精品国产一区二区三区色欲| 超碰国产天天做天天爽| 亚洲国产精品无码久久秋霞| 无码午夜人妻一区二区三区不卡视频| 午夜精品一区二区三区免费视频| 老太脱裤子让老头玩xxxxx| 日韩av片无码一区二区三区| 午夜福利视频1692| 四虎免费大片aⅴ入口| 丰满人妻一区二区三区无码av | 亚洲无线码中文字幕在线| 色欲国产麻豆一精品一av一免费| 亚洲日韩中文字幕一区| 久久久久国产精品人妻aⅴ院| 韩国 欧美 日产 国产精品| 一个人看的免费高清www视频| 国模精品一区二区三区| 国产真实乱人偷精品视频| 成人无码视频97免费| 天堂无码人妻精品av一区| av在线播放无码线| 亚洲337少妇裸体艺术| 国产男女免费完整视频在线| 国产性天天综合网| 亚在线观看免费视频入口| 亚洲狠狠色成人综合网| 久久久肥妇熟女ⅹxxx毛片| 欧美日韩亚洲国内综合网| 少妇人妻精品一区二区| 国产国产成人久久精品| 在线看片福利无码网址|