在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human GRAM domain-containing protein 1A (GRAMD1A)

  • 中文名稱:
    人GRAMD1A重組蛋白
  • 貨號(hào):
    CSB-CF842650HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    GRAMD1A
  • Uniprot No.:
  • 別名:
    GRAMD1A; KIAA1533; Protein Aster-A; GRAM domain-containing protein 1A
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-724
  • 氨基酸序列
    MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPST QSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILL QGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTS FGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLG TPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVD SQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLA ALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQR RVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYC ILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEE GGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGP GAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTA TEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPD DSFS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain. At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER. May play a role in tumor progression. Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol-transfer activity.
  • 基因功能參考文獻(xiàn):
    1. STAT5 was the target of GRAMD1A; GRAMD1A regulated the target genes of STAT5 and the transcriptional activity of STAT5. Inhibition of STAT5 in indicated HCC cells overexpressing GRAMD1A suppressed the effects of GRAMD1A on the self-renewal of HCC stem cell, resistance to chemotherapy and tumor growth, suggesting GRAMD1A promoted the self-renewal of HCC stem cells and the development of HCC by increasing STAT5 level. PMID: 27585821
  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle, autophagosome.
  • 組織特異性:
    Expressed in liver.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 29305

    KEGG: hsa:57655

    STRING: 9606.ENSP00000441032

    UniGene: Hs.515351



主站蜘蛛池模板: 文中字幕一区二区三区视频播放| 虎白女粉嫩尤物福利视频| 国语自产精品视频在 视频| 国产精品不卡无码av在线播放| 狠狠躁天天躁夜夜躁婷婷| 午夜亚洲国产理论片中文| 亚洲-av-无限看| 成人性能视频在线| 香蕉视频在线精品视频| 在线人成免费视频69国产| 九个美女露脸撒尿嘘嘘视频| 丰满人妻熟妇乱偷人无码| 最新精品国偷自产在线美女足| 非洲黑人性xxxx精品| 国产suv精品一区二区6 | 精品亚洲国产成人a片app| 57pao成人国产永久免费视频| 国产av无码专区亚汌a√| 久久久久中文伊人久久久| 国产成人精品午夜福利在线观看 | 国产无遮挡色视频免费观看性色| aaaaa少妇高潮大片| 国模无码大尺度一区二区三区| 亚洲6080yy久久无码产自国产 | 无码高潮喷吹在线观看| 日本一区二区更新不卡| 国产精品无码翘臀在线观看| 国产精品毛多多水多| 精品少妇无码一区二区三批| 午夜爽爽爽男女污污污网站| 国产探花在线精品一区二区| 中文字幕乱码中文乱码777| 国产成人无码一二三区视频| 越南女子杂交内射bbwxz| 天堂√最新版中文在线天堂| 久久久久国产精品| 人妻内射一区二区在线视频 | 8ⅹ8x擦拨擦拨成人免费视频| 男女野外做爰全过程69影院| 成人欧美一区二区三区黑人 | 狠狠色丁香久久婷婷综合蜜芽五月|