在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Dual oxidase maturation factor 2 (DUOXA2)

  • 中文名稱:
    人DUOXA2重組蛋白
  • 貨號:
    CSB-CF007231HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    DUOXA2; Dual oxidase maturation factor 2; Dual oxidase activator 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-320
  • 氨基酸序列
    MTLWNGVLPFYPQPRHAAGFSVPLLIVILVFLALAASFLLILPGIRGHSRWFWLVRVLLS LFIGAEIVAVHFSAEWFVGTVNTNTSYKAFSAARVTARVRLLVGLEGINITLTGTPVHQL NETIDYNEQFTWRLKENYAAEYANALEKGLPDPVLYLAEKFTPSSPCGLYHQYHLAGHYA SATLWVAFCFWLLSNVLLSTPAPLYGGLALLTTGAFALFGVFALASISSVPLCPLRLGSS ALTTQYGAAFWVTLATGVLCLFLGGAVVSLQYVRPSALRTLLDQSAKDCSQERGGSPLIL GDPLHKQAALPDLKCITTNL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis.
  • 基因功能參考文獻:
    1. This study reports the pedigree with goitrous congenital hypothyroidism (GCH) due to the coexistence of heterozygous mutations in the DUOX2 and DUOXA2 genes. PMID: 28541007
    2. DUOXA2 gene mutation is a common molecular pathogenic basis for congenital hypothyroidism children with suspected thyroid dyshormonogenesis in Guangzhou. PMID: 28100324
    3. inactivating mutations in the DUOXA2 (p.Y246X) and DUOX2 (p.R885Q) genes were identified in a set of dizygotic twins with congenital hypothyroidism PMID: 27349010
    4. The folding of DUOX2 appears to be a key event in the trafficking of the DUOX2/DUOXA2 complex as it promotes an appropriate conformation of the N-terminal region, which is propitious to subsequent covalent interactions with the maturation factor, DUOXA2. PMID: 25761904
    5. a novel DUOXA2 mutation (I26M) causing congenital hypothyroidism with goiter, which affected H2O2 generation but did not alter the protein expression levels, further confirming the essential role of DUOXA2 in thyroid hormone synthesis. PMID: 25675383
    6. The DUOX-expressing model, the human intestinal Caco-2 cell line, expression of DUOXA2 mRNA was also positively modulated by IL-4 and IL-13. PMID: 23010498
    7. DUOXA2 is Significantly Upregulated in Active Ulcerative Colitis and during Progression to Dysplasia. PMID: 24492313
    8. This study is the first to report a novel c.413-414insA (Y138X) mutation for congenital hypothyroidism, thereby expanding the mutational spectrum of the DUOXA2 gene. PMID: 23292166
    9. Two functionally important single-nucleotide polymorphisms within the promoter differentially regulate DUOX2/DUOXA2 transcription in response to exogenous double-stranded DNA. PMID: 22592922
    10. Native DUOXA2 would constrain DUOX2 to produce H(2)O(2). PMID: 22814254
    11. Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines. PMID: 21321110
    12. co-expression of DUOXA2, an ER-resident transmembrane protein, allows ER-to-Golgi transition, maturation, and translocation to the plasma membrane of functional DUOX2 in a heterologous system PMID: 16651268
    13. DUOXA2 allows rapid ER exit of folded DUOX2 or enhanced degradation of mutant DUOX2 proteins not competent for ER exit. PMID: 17374849
    14. Results provide evidence for the critical role of DUOXA2 in thyroid hormonogenesis. Biallelic DUOXA2 mutations are a novel genetic event in permanent congenital hypothroidism. PMID: 18042646
    15. The five gene transcripts (aldolase B, elafin, MST-1, simNIPhom and SLC6A14) were changed in patients with ulcerative colitis, and were related to the disease activity. PMID: 18700007
    16. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. PMID: 19339556

    顯示更多

    收起更多

  • 相關疾病:
    Thyroid dyshormonogenesis 5 (TDH5)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    DUOXA family
  • 組織特異性:
    Specifically expressed in thyroid. Also detected in salivary glands.
  • 數據庫鏈接:

    HGNC: 32698

    OMIM: 274900

    KEGG: hsa:405753

    STRING: 9606.ENSP00000319705

    UniGene: Hs.497987



主站蜘蛛池模板: 亚洲综合av一区二区三区| 激情97综合亚洲色婷婷五| 日本一区二区更新不卡| 无码不卡中文字幕av| 久热爱精品视频线路一| 男人添女人囗交做爰视频| 竹菊影视欧美日韩一区二区三区四区五区 | 国产精品久久久久9999不卡| 成人奭片免费观看| 精品无码国产一区二区三区51安| 大肉大捧一进一出好爽视频动漫| 亚洲人成亚洲精品| 久久久久无码精品国产人妻无码| 久久99精品久久久久久蜜芽| 国产呻吟久久久久久久92| 亚洲人成在线影院| 无码人妻久久一区二区三区不卡| 免费看撕开奶罩揉吮奶头视频| 免费乱码人妻系列无码专区| 久人人爽人人爽人人片av| 人妻免费一区二区三区最新| 亚洲中文字幕无码卡通动漫野外 | 日本精品人妻无码免费大全| 欧美一区内射最近更新| 18禁真人抽搐一进一出在线| 亚洲男人的天堂在线aⅴ视频| 成人精品视频99在线观看免费| 狠狠色噜噜狠狠狠狠av不卡| 亚洲美女高清aⅴ视频免费| 日韩人妻ol丝袜av一二区| 欧美精品久久天天躁| 在线观看一区二区三区国产免费| 蜜臀视频一区二区在线播放| 国产98在线 | 免费、| 免费国产a国产片高清| 人人做人人爽久久久精品| 日韩吃奶摸下aa片免费观看| 色丁香婷婷综合久久| 浪荡女天天不停挨cao日常视频| 在线视频国产制服丝袜| 亚洲成a人片在线不卡一二三区|