在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human DNA damage-regulated autophagy modulator protein 2 (DRAM2)

  • 中文名稱:
    人DRAM2重組蛋白
  • 貨號(hào):
    CSB-CF754411HU
  • 規(guī)格:
  • 來(lái)源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    DRAM2
  • Uniprot No.:
  • 別名:
    DRAM2; TMEM77; PSEC0031; UNQ154/PRO180; DNA damage-regulated autophagy modulator protein 2; Transmembrane protein 77
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-266
  • 氨基酸序列
    MWWFQQGLSFLPSALVIWTSAAFIFSYITAVTLHHIDPALPYISDTGTVAPEKCLFGAML NIAAVLCIATIYVRYKQVHALSPEENVIIKLNKAGLVLGILSCLGLSIVANFQKTTLFAA HVSGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSALSMLTCSSVL HSGNFGTDLEQKLHWNPEDKGYVLHMITTAAEWSMSFSFFGFFLTYIRDFQKISLRVEAN LHGLTLYDTAPCPINNERTRLLSRDI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
  • 基因功能參考文獻(xiàn):
    1. Mycobacterium tuberculosis significantly induces the expression of MIR144*/hsa-miR-144-5p, which targets the 3'-untranslated region of DRAM2. PMID: 27764573
    2. Genetic variants on chromosome 1p13.3 near the damage-regulated autophagy modulator 2 gene DRAM2 associated with Non-ST Elevation Myocardial Infarction (rs656843; odds ratio 1.57, P = 3.11 x 10(-10)) in the case-control analysis. PMID: 26509668
    3. Recessive variants in DRAM2, an autophagy regulator gene, have been recently identified as a cause of retinal dystrophy with early macular involvement PMID: 26720460
    4. Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement. PMID: 25983245
    5. The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction. PMID: 21584698
    6. reduced expression of DRAM2 may contribute to enhanced cell survival in tumor cells. PMID: 19895784
    7. DRAM2 is different from DRAM as it not induced by p53 or p73. DRAM2 is also a lysosomal protein, its overexpression does not modulate autophagy. PMID: 19556885

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Lysosome membrane; Multi-pass membrane protein. Photoreceptor inner segment. Apical cell membrane.
  • 蛋白家族:
    DRAM/TMEM150 family
  • 組織特異性:
    Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Expressed in the retina. Not detected in brain or thymus.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 28769

    OMIM: 613360

    KEGG: hsa:128338

    UniGene: Hs.485606



主站蜘蛛池模板: 婷婷四房色播| 日韩欧群交p片内射中文| 国产日韩在线时看高清视频| 51久久成人国产精品麻豆| 粗壮挺进人妻水蜜桃成熟漫画 | 小污女导航福利入口| 自拍偷自拍亚洲精品情侣| 欧美性插b在线视频网站| 正在播放国产真实哭都没用| 亚洲制服丝袜自拍中文字幕 | 97国产在线看片免费人成视频| 久久精品人人做人人综合| 精品人妻人人做人人爽夜夜爽| а天堂8中文最新版在线官网| 永久免费的无码中文字幕| 超清制服丝袜无码av福利网| 亚洲精品久久婷婷丁香51| 国产精品露脸国语对白| 四虎成人精品在永久在线| 无码av片在线观看免费| 秋霞av鲁丝片一区二区| 丰满少妇弄高潮了www| a毛看片免费观看视频| 国产日韩精品视频无码| 国产精品夜色一区二区三区| 波多野结衣美乳人妻hd电影欧美 | 精品人妻伦一二三区久久| a 'v片欧美日韩在线| 性色av一区二区三区咪爱四虎| 欧美乱妇日本无乱码特黄大片| 韩国精品福利一区二区三区| 国产av高清无亚洲| 亚洲国产欧美在线观看片不卡| 少妇与子乱毛片| 一区二区三区国产亚洲网站| 欧洲vat一区二区三区| 又紧又黄的免费视频网站| 最新亚洲人成网站在线观看| 亚洲人成网站18禁止人| 免费人成激情视频在线观看 | 无码日本精品xxxxxxxxx|