在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cell cycle control protein 50A (TMEM30A)

  • 中文名稱:
    人TMEM30A重組蛋白
  • 貨號:
    CSB-CF865146HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    TMEM30A; C6orf67; CDC50A; Cell cycle control protein 50A; P4-ATPase flippase complex beta subunit TMEM30A; Transmembrane protein 30A
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-361
  • 氨基酸序列
    AMNYNAKDEVDGGPPCAPGGTAKTRRPDNTAFKQQRLPAWQPILTAGTVLPIFFIIGLIF IPIGIGIFVTSNNIREIEIDYTGTEPSSPCNKCLSPDVTPCFCTINFTLEKSFEGNVFMY YGLSNFYQNHRRYVKSRDDSQLNGDSSALLNPSKECEPYRRNEDKPIAPCGAIANSMFND TLELFLIGNDSYPIPIALKKKGIAWWTDKNVKFRNPPGGDNLEERFKGTTKPVNWLKPVY MLDSDPDNNGFINEDFIVWMRTAALPTFRKLYRLIERKSDLHPTLPAGRYSLNVTYNYPV HYFDGRKRMILSTISWMGGKNPFLGIAYIAVGSISFLLGVVLLVINHKYRNSSNTADITI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations.
  • 基因功能參考文獻:
    1. results indicated that the extracellular domain of CDC50A has important roles both in CDC50A's ability to chaperone ATP11C to the plasma membrane and in inducing ATP11C's ATP hydrolysis-coupled flippase activity. PMID: 29276178
    2. Data indicate that the lipid flippase (ATP8B1)-transmembrane protein 30A (CDC50A) heterodimer is essential for the apical localization of sodium-dependent bile acid transporter (SLC10A2/ASBT) in Caco-2 cells. PMID: 25239307
    3. ATP11C and CDC50A are required for aminophospholipid translocation from the outer to the inner plasma membrane leaflet; that is, they display flippase activity. PMID: 24904167
    4. the phospholipid flippase complex of ATP8A1 and CDC50A proteins has a role in cell migration PMID: 23269685
    5. Import of choline phospholipids into Saccharomyces cerevisiae DeltaLem3 vector is partially reconstituted by human TMEM30a and by Lem3p-TMEM30a chimeras, showing that the proteins are orthologous. PMID: 21289302
    6. CDC50A plays a key role in perifosine uptake in human cells, presumably by forming a functional plasma membrane translocator. PMID: 20510206
    7. CDC50A may be the potential beta-subunit or chaperone for ATP8B1 in hepatocytes. PMID: 17948906

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Multi-pass membrane protein. Cell membrane. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle membrane. Apical cell membrane.
  • 蛋白家族:
    CDC50/LEM3 family
  • 數據庫鏈接:

    HGNC: 16667

    OMIM: 611028

    KEGG: hsa:55754

    STRING: 9606.ENSP00000230461

    UniGene: Hs.108530



主站蜘蛛池模板: 乱人伦无码中文视频在线| 色一情一乱一伦| 精品女同一区二区三区免费站| 欧美亚洲国产精品久久蜜芽 | 亚洲小说区图片区另类春色| 女同亚洲一区二区无线码| 国精产品69永久中国有限 | 好吊射视频988gaocom| 国产欧美日韩中文久久| 国产又黄又猛又粗又爽的a片动漫| 国产99久久久国产精品免费看| 日本真人边吃奶边做爽动态图 | 成在人线av无码免费高潮喷水 | 国产台湾无码av片在线观看| 色妞色综合久久夜夜| 日韩人妻无码一区二区三区99| 国产在线无码一区二区三区 | 插一插射一射视频| 99国产精品国产精品九九| 日韩a无v码在线播放| 夜夜欢性恔真人免费视频| 亚洲 a v无 码免 费 成 人 a v| 国模无码一区二区三区| 亚洲精品夜夜夜妓女网| 国产欧美另类久久久精品不卡| 精品欧美一区二区在线观看| 国产特级毛片aaaaaa| 狠狠色老熟妇老熟女| 国产精品免费看久久久无码| 亚洲精品亚洲人成人网| 久久九九精品国产综合喷水| 777米奇色狠狠俺去啦奇米77| 无码专区一va亚洲v专区在线| 天天做天天躁天天躁| aaa午夜级特黄日本大片| 天堂网www在线资源网| 色婷婷狠狠久久综合五月| 十八禁啪啪无遮挡网站| 99亚洲乱人伦aⅴ精品| 天天色影网| 精品国产av最大网站|