在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Human Bone marrow proteoglycan (PRG2)

Recombinant Human Bone marrow proteoglycan (PRG2)

In Stock
  • 中文名稱：
    人PRG2重組蛋白
  • 貨號：
    CSB-CF018670HUa2
  • 規(guī)格：
    ￥5028
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    PRG2
  • Uniprot No.：
  • 別名：
    PRG2; MBP; Bone marrow proteoglycan; BMPG; Proteoglycan 2
  • 種屬：
    Homo sapiens(Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    in vitro E.coli expression system
  • 分子量：
    29.8kDa
  • 表達(dá)區(qū)域：
    106-222aa
  • 氨基酸序列
    TCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-SUMO-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
  • 基因功能參考文獻(xiàn)：
    1. Low PRG2 expression is associated with drug resistance in Chronic myeloid leukemia. PMID: 29936783
    2. MBP-1 aggregation is important for innate immunity and immunopathology mediated by eosinophils.MBP-1 toxicity is restrained via crystallization in eosinophil secretory granules. PMID: 25728769
    3. free protein in nasal mucus can be used as a biomarker to diagnose chronic rhinosinusitis PMID: 25266917
    4. mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation. PMID: 24814827
    5. This protein contains a peptide that displays strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. PMID: 319906
    6. Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-beta1. PMID: 24112102
    7. During pregnancy, the proform of eosinophil major basic protein-angiotensinogen constitutes the major form in late pregnancy. PMID: 23033876
    8. Combinations of respiratory syncytial virus and MBP synergistically induced cell death in pulmonary alveolar epithelial cells (A549). PMID: 20977431
    9. The expression of MBP in nasal mucus obtained from chronic rhinosinusitispatients was obviously higher than that of nasal mucus obtained from controls. PMID: 18720885
    10. MBP and NE collaborated to cause the pathological effects of nasal polyps. PMID: 18476621
    11. novel transcript was alternatively transcribed from intron III of the ENO1 gene and was feasible for MBP-1 production PMID: 20849415
    12. The proMBP is a novel first trimester serum marker for adverse pregnancy outcome. PMID: 19626619
    13. Transcription is regulated by novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms. PMID: 12202480
    14. IGF bioactivity is regulated by reversible cell surface binding of PAPP-A, which in turn is regulated by proMBP PMID: 12370176
    15. MBP's structure is described, and its ability to bind to pregnancy-associated plasma protein A explained PMID: 12421832
    16. Deposits of eosinophilic MBP are found on the surface of eosinophils and damaged muscle fibers surrounded by eosinophils in patients with idiopathic eosinophilic myositis. PMID: 12534990
    17. MBP stimulates a Src kinase-dependent activation of class I(A) phosphoinositide 3-kinase and, in turn, activation of protein kinase C zeta in neutrophils, which contributes to the activation of NADPH oxidase and resultant superoxide production. PMID: 14500673
    18. Proform of MPB forms a covalent complex with PAPPA in which PAPPA is inhibited. PMID: 14988014
    19. the proform of eosinophil major basic protein inhibits the proteolytic activity of PAPP-A PMID: 15647258
    20. two regions shown previously to contain the cytotoxic and cytostimulatory properties of MBP are accessible for ligand interaction in cell surface-bound MBP PMID: 16940047
    21. Compared to MBP1, which is present in eosinophils, basophils, and a human mast cell line, homologous MBP2 is present only in eosinophils and may be a useful biomarker for eosinophil-associated diseases. PMID: 17082653
    22. Pregnancy-associated plasma protein A is involved in processes preceding vulnerable plaque development in acute coronary syndrome. PMID: 17223728
    23. knockdown of endogenous MBP-1 is involved in cellular senescence of HFF through p53-p21 pathway. PMID: 18852884
    24. No variation in genes major basic protein for Atopic dermatitis pathogenesis in this German cohort PMID: 19014520
    25. The significantly elevated levels of proMBP in myelofibrosis patients implies that proMBP could be an important stromal cytokine in bone marrow fibrosis. PMID: 19039208
    26. addition to granule-stored MBP, even unstimulated eosinophils contained appreciable amounts of MBP within secretory vesicles PMID: 19398958

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Bone marrow proteoglycan]: Secreted. Note=The proform is secreted.; [Eosinophil granule major basic protein]: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
  • 組織特異性：
    High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and co
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9362

    OMIM: 605601

    KEGG: hsa:5553

    STRING: 9606.ENSP00000312134

    UniGene: Hs.512633



主站蜘蛛池模板： 丰满熟妇被猛烈进入高清片| 日本高清在线天码一区播放| 猫咪免费人成网站在线观看| 亚洲欧美成人一区二区在线电影| 欧美黑人又大又粗xxxxx| 成人精品一区日本无码网站 | 欧美乱大交aaaa片if| 四虎永久地址www成人久久| 天堂网在线观看| 在线播放五十路熟妇| 在线高清亚洲精品二区| 久久精品国产只有精品66| 亚洲va韩国va欧美va| 中文字幕在线免费看线人| 国产av高清无亚洲| 亚洲日韩国产精品无码av| 亚洲精品www久久久| 精品久久久久久无码人妻| 欧美国产激情一区二区在线| 裸体丰满白嫩大尺度尤物| 欧美乱妇日本无乱码特黄大片 | 精品无人乱码高清在线观看 | 精品国产三级a在线观看| 国产超碰人人做人人爱| 在线观看老湿视频福利| 老妇肥熟凸凹丰满刺激| 精品午夜福利在线视在亚洲 | 亚洲精品久久久无码大桥未久| 亚洲日韩一区二区| 欧美成人精品手机在线| 欧美日韓性视頻在線| 中文无码人妻影音先锋| 国产精品亚洲αv天堂无码| 狠狠色噜噜狠狠狠狠888奇禾 | 中文字幕在线精品视频| 国产精品99久久免费黑人人妻| 少妇白浆呻吟爽| 日本动漫瀑乳h动漫啪啪免费 | 久久www免费人成一看片| 国产成人+亚洲欧洲+综合| 最新国产精品无码|