在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Human Blood vessel epicardial substance (BVES)

Recombinant Human Blood vessel epicardial substance (BVES)

  • 中文名稱(chēng)：
    Recombinant Human Blood vessel epicardial substance(BVES)
  • 貨號(hào)：
    CSB-CF002887HU
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    BVES
  • Uniprot No.：
  • 別名：
    BVES; POP1; POPDC1; Blood vessel epicardial substance; hBVES; Popeye domain-containing protein 1; Popeye protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-360
  • 氨基酸序列
    MNYTESSPLRESTAIGFTPELESIIPVPSNKTTCENWREIHHLVFHVANICFAVGLVIPT TLHLHMIFLRGMLTLGCTLYIVWATLYRCALDIMIWNSVFLGVNILHLSYLLYKKRPVKI EKELSGMYRRLFEPLRVPPDLFRRLTGQFCMIQTLKKGQTYAAEDKTSVDDRLSILLKGK MKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIIADDNCRFLCWSRERLTYFLE SEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKAKKLEHQLSLCTQISMLEMRNSIASSS DSDDGLHQFLRGTSSMSSLHVSSPHQRASAKMKPIEEGAEDDDDVFEPASPNTLKVHQLP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.
  • 基因功能參考文獻(xiàn)：
    1. Functional suppression of POPDC1 promoted breast cancer cell migration and proliferation, cAMP interacts with POPDC1 and up-regulates its expression in breast cancer cells. PMID: 28954821
    2. recently a novel family of cAMP effector proteins emerged and was termed the Popeye domain containing (POPDC) family, which consists of three members POPDC1, POPDC2 and POPDC3. POPDC proteins are transmembrane proteins, which are abundantly present in striated and smooth muscle cells. POPDC proteins bind cAMP with high affinity comparable to PKA PMID: 28939104
    3. Study shows that EGFR negatively regulates POPDC1 expression in breast cancer cell lines and that overexpression of POPDC1 can reduce EGFR-mediated cell migration and proliferation in breast cancer cells. PMID: 28807821
    4. BVES plays a key role in maintaining the integrity of the colonic mucosa and protecting from inflammatory carcinogenesis. Results also suggest that BVES promotes the post-translational degradation of c-Myc. PMID: 28389570
    5. Forced expression of POPDC1(S201F) in a murine cardiac muscle cell line (HL-1) increased hyperpolarization and upstroke velocity of the action potential PMID: 26642364
    6. These results suggest that down-regulation of BVES in hepatocellular carcinoma induces epithelial-mesenchymal transition, thus promoting invasion and metastasis in HCC cells. PMID: 24442236
    7. Coding sequence and splice junctions of BVES were sequenced in 114 unrelated patients with Tetralogy of Fallot and 400 unrelated healthy individuals.Four novel BVES mutations were identified in patients with TOF but not in the 400 controls. PMID: 23403794
    8. Popdc1 (Bves) modulates cardiac pacemaker activity in response to stress and displays high expression levels in the sinus node. The Popeye domain acts as a high-affinity cAMP binding domain and Popdc proteins interact with the ion channel TREK-1. PMID: 22354168
    9. Low Bves expression is associated with gastric cancer progression. PMID: 22109561
    10. BVES was found to be underexpressed in all stages of colorectal carcinoma and in adenomatous polyps, indicating its suppression occurs early in transformation. PMID: 21911938
    11. Bves expression and localization can regulate RhoA and ZONAB/DbpA activity. PMID: 21283798
    12. Data suggest that POPDC gene expression is modified in end-stage heart failure in humans in a manner suggesting regulatory and/or functional differences between the three family members and that POPDC1 is particularly susceptible to this condition. PMID: 21069264
    13. Frequent silencing of BVES is associated with promoter hypermethylation in gastric cancer. PMID: 20627872
    14. Methylation of BVES was present in 80% of NSCLC tissues but only 14% of noncancerous tissues. PMID: 18349282

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Limb-girdle muscular dystrophy 2X (LGMD2X)
  • 亞細(xì)胞定位：
    Lateral cell membrane. Cell junction, tight junction. Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Membrane, caveola.
  • 蛋白家族：
    Popeye family
  • 組織特異性：
    Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1152

    OMIM: 604577

    KEGG: hsa:11149

    STRING: 9606.ENSP00000313172

    UniGene: Hs.221660



主站蜘蛛池模板： 色偷偷88888欧美精品久久久| av无码久久久久不卡网站蜜桃| 无码人妻一区二区三区线| 中文天堂在线www| 久久99精品国产麻豆| 国产精品狼人久久久久影院| 无码中出人妻中文字幕av| 亚洲精品无码不卡在线播放| 精品国产人成亚洲区| 无码精品一区二区三区在线| 人人人爽人人爽人人av| 亚洲午夜久久久无码精品网红a片| 国产3p露脸普通话对白| 亚洲国产aⅴ成人精品无吗 | 顶级欧美熟妇xx| 狠狠色噜噜狠狠狠狠av不卡| 影音先锋无码a∨男人资源站| 亚洲伊人久久大香线蕉av| 伊人色综合一区二区三区| 国产高清在线精品一本大道| 人人澡人人澡人人看添av| 夜夜欢天天干| 无码专区男人本色| 成人一区二区免费中文字幕视频| 国产综合一区二区三区黄页秋霞| 中文字幕爆乳julia女教师| 色欲av无码一区二区三区| 久久精品99无色码中文字幕| 亚洲国产欧美在线人成| 无码免费毛片手机在线无卡顿| 亚洲精品欧美综合四区| 中文字字幕在线乱码视频| 婷婷射精av这里只有精品| 色妞色视频一区二区三区四区| 波多野结衣乱码中文字幕| 亚洲免费视频免在线观看| 国产超碰人人做人人爱ⅴa| 2021年国产精品专区丝袜| 久青青在线观看视频国产| 国产麻豆剧传媒精品国产av | 热99re久久国超精品首页|