在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Alpha-1B adrenergic receptor (ADRA1B)

  • 中文名稱:
    Recombinant Human Alpha-1B adrenergic receptor(ADRA1B)
  • 貨號:
    CSB-CF001386HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    ADRA1B; Alpha-1B adrenergic receptor; Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達(dá)區(qū)域:
    1-520
  • 氨基酸序列
    MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
  • 基因功能參考文獻(xiàn):
    1. ADRA1B rs10070745 was significantly associated with vasoconstrictor responses. PMID: 27089938
    2. Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.( PMID: 27834678
    3. protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein-mediated signaling turn-off. PMID: 28082304
    4. eIF3f/alpha adrenergic receptor interaction PMID: 26497985
    5. heteromeric receptor complexes between alpha1A-AR and CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction PMID: 25775528
    6. alpha1B-AR signals through calcium, ERK1/2 and p38 only when located in the membrane and the signals disappear by membrane disruption. PMID: 23717684
    7. A rare ADRA1B haplotype composed of six single nucleotide polymorphism(SNP)s is associated with attention deficit hyperactivity disorder (ADHD). PMID: 23052569
    8. Noradrenaline facilitated cell proliferation by regulation of potassium currents in human osteoblasts via G(i/o) -protein-coupled alpha(1B) -adrenoceptors, not via coupling to Gq-proteins PMID: 23061915
    9. Through beta-D receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands. PMID: 22723743
    10. Data show that sphingosine 1-phosphate can induce alpha1B-adrenergic receptor internalization and that its autocrine/paracrine generation is relevant for internalization induced by IGF-I. PMID: 22019450
    11. alpha1b and alpha2c AR is over-expressed in basal-like breast tumours of poor prognosis PMID: 21298476
    12. The mRNA expression of alpha1b-AR subtypes in bladder detrusor and posterior urethra was significantly lower in the inflammation group than in controls. PMID: 21223784
    13. A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation. PMID: 21224381
    14. These results are the first to demonstrate alpha1-ARs on human coronary ECs and indicate that the alpha1B subtype is predominant. PMID: 20857090
    15. the alpha(1B)-AR has differential effects on the phosphorylation status of the STAT3 pathway and may not be as prohypertrophic as the other two subtypes. PMID: 12695539
    16. heterodimerization with alpha1B-adrenergic receptors controls cell surface expression of alpha1D-adrenergic receptors PMID: 14736874
    17. the alpha(1B)-adrenoreceptor has a role in the inhibition of migration of human aortic smooth muscle cells PMID: 15220331
    18. alpha(1B)-adrenergic receptor expression causes a cell cycle progression and may induce transformation in sensitive cell lines. PMID: 15297446
    19. Human ureter was endowed with each alpha1 AR subtype, although alpha1D and alpha1A ARs were prevalent over alpha1B ARs PMID: 15690361
    20. These results indicate that the thio-acylation status of the alpha1b-adrenoceptor does not regulate G protein activation whereas thio-acylation of Galpha11 plays a key role in activation by the receptor. PMID: 16297597
    21. Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling. PMID: 16352594
    22. the ADRA1B is able to form oligomeric rather than only simple dimeric complexes and disruption of effective oligomerization by introducing mutations into transmembrane domain IV has profound consequences for cell surface delivery and function PMID: 17220353
    23. alpha1B-ARs are the major alpha1-AR subtype expressed in DU145, PC3, and all TRAMP cell lines, but most of the receptor is localized in intracellular compartments in a nonfunctional state, which can be rescued upon prolonged incubation with any ligand. PMID: 17365508
    24. expression in distal ureter significantly higher than in proximal and mid ureter PMID: 17973108
    25. ADRA1B expression was increased in end stage renal disease. Functional receptor changes mediated vascular hypersensitivity to phenylephrine. PMID: 18257748
    26. Pharmacological profile of alpha 1B-adrenoceptors for ketanserin is strongly influenced by the assay conditions. PMID: 18336813
    27. These findings demonstrate differences in internalization between the alpha1a- and alpha1b-AR and provide evidence that the lack of significant endocytosis of the alpha1a-AR is linked to its poor interaction with beta-arrestins as well as with AP50. PMID: 18523139
    28. Functional alpha1- and beta2-adrenergic receptors in human osteoblasts. PMID: 19334040
    29. Report alpha1A and alpha1B subtypes are both present in human myocardium, but alpha1D binding is not, and the alpha1 subtypes are not downregulated in heart failure. PMID: 19919991

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
  • 蛋白家族:
    G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA1B sub-subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 278

    OMIM: 104220

    KEGG: hsa:147

    STRING: 9606.ENSP00000306662

    UniGene: Hs.368632



主站蜘蛛池模板: 69成人免费视频无码专区| 欧美精品一区二区蜜臀亚洲| 天天躁日日躁狠狠躁av麻豆男男| 久久综合狠狠色综合伊人| 国产伦子系列沙发午睡| 亚洲精品欧美综合四区| 亚洲国产精品无码av| 亚洲精品中文字幕一区二区三区| 少妇人妻偷人激情视频| 性色做爰片在线观看ww| 一区二区三区中文字幕| 欧洲亚洲国产成人综合色婷婷| 国产成年女人特黄特色毛片免| 日本中文字幕乱码免费| 久久成人影院精品777| 欧美大黑帍在线播放| 欧美综合乱图图区乱图图区| 国产欧美国日产高清| 狠狠综合久久综合88亚洲| 高中生自慰www网站| 久久综合亚洲鲁鲁五月天| 久久三级中文欧大战字幕| 亚洲国产精品无码久久| 亚洲性久久久影院| 老熟女 露脸 嗷嗷叫| 亚洲中文字幕av不卡无码| 亚洲日本va在线视频观看| 久久丫精品系列| 精品欧洲av无码一区二区三区 | 成人美女黄网站色大免费的| 99在线精品免费视频| 色老头av亚洲一区二区男男| 国产超碰人人做人人爽av大片| 无码国产69精品久久久久网站| 老外和中国女人毛片免费视频| 香蕉蕉亚亚洲aav综合| 午夜福利日本一区二区无码| 女人下边被添全过视频| 人妻丝袜av先锋影音先| 精品一区二区成人精品| 国产精品久久久久久人妻精品动漫|