在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human ATP-sensitive inward rectifier potassium channel 15 (KCNJ15)

  • 中文名稱:
    人KCNJ15重組蛋白
  • 貨號(hào):
    CSB-CF860350HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    KCNJ15
  • Uniprot No.:
  • 別名:
    KCNJ15; KCNJ14; ATP-sensitive inward rectifier potassium channel 15; Inward rectifier K(+ channel Kir1.3; Inward rectifier K(+ channel Kir4.2; Potassium channel, inwardly rectifying subfamily J member 15
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-375
  • 氨基酸序列
    MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVID MKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLF SLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKF SHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVD SSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSY IPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQ RERELRTLLLQQSNV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
  • 基因功能參考文獻(xiàn):
    1. KCNJ15 couples with polyamines in sensing weak electric fields. PMID: 26449415
    2. RNA-seq evidence of biallelic expression of KCNJ15 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of KCNJ15 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
    3. KCNJ15 has a major role in histamine-stimulated gastric acid secretion. PMID: 26108660
    4. We had performed a replication study using an independent larger Japanese population for the association of rs3746876 within KCNJ15, and observed a significant association of rs3746876 with type 2 diabetes, but this study failed to find original finding. PMID: 23595124
    5. It was shown that downregulation of Kcnj15 leads to increased insulin secretion in vitro and in vivo. The mechanism for regulating insulin secretion inolved a calcium-sensiong receptor. PMID: 22566534
    6. KCNJ15 is a previously unreported susceptibility gene for T2DM among Asians PMID: 20085713
    7. maintaining electrical integrity of bile-generating hepatocytes. PMID: 11804844
    8. The potential synergy and consequences of the overexpression of KIR4.2 and KIR3.2 in Down's syndrome brain development are discussed. PMID: 15068243
    9. MUPP1 and Kir4.2 may participate in a protein complex in the nephron that could regulate transport of K(+) as well as other ions. PMID: 19420109

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ15 subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6261

    OMIM: 602106

    KEGG: hsa:3772

    STRING: 9606.ENSP00000331698

    UniGene: Hs.411299



主站蜘蛛池模板: 国产精品成人va在线观看| 无码啪啪熟妇人妻区| 大胆日本熟妇xxxx| 两个黑人大战嫩白金发美女| 国产成人精品三上悠亚| 色综合天天综合天天更新| 国产成人av乱码免费观看| 久久久久久国产精品免费免费 | 丰满人妻被公侵犯高清版| 黄网站色视频免费观看| 波多野结衣免费一区视频| 亚洲成色www久久网站| 亚洲处破女av日韩精品| 内射小寡妇无码| 亚洲色精品三区二区一区| 久久这里只精品国产免费10| 亚洲中文字幕无码永久| 国产一卡2卡3卡4卡国色天香| 久爱www成人网免费视频| 国产另类ts人妖一区二区| 成视频年人黄网站视频福利| 日本日本乱码伦专区| 久久久久波多野结衣高潮| 久久久久人妻精品一区三寸| 午夜无码片在线观看影院y| 国产国拍精品av在线观看按摩| 亚洲字幕av一区二区三区四区| 无码精品a∨在线观看无广告| 国内免费视频成人精品| 日产精品久久久久久久性色| 国产欧美日韩| 中文无码一区二区视频在线播放量 | 日本一卡2卡3卡4卡免费乱码网站| 国产精品免费福利久久| 久久精品欧美日韩精品| 制服丝袜有码中文字幕在线| 好大好硬好爽免费视频| 欧美在线看片a免费观看| 男人猛戳女人30分钟视频大全| 网禁拗女稀缺资源在线观看| 国产在线 | 中文|