在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human ATP-binding cassette sub-family G member 4 (ABCG4)

  • 中文名稱:
    Recombinant Human ATP-binding cassette sub-family G member 4(ABCG4)
  • 貨號:
    CSB-CF887952HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    ABCG4
  • Uniprot No.:
  • 別名:
    ABCG4; WHITE2; ATP-binding cassette sub-family G member 4
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-646
  • 氨基酸序列
    MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVD IEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE SGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL VTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV SLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCP TYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDP IESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQV VCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPV TAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFR EPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment. Induces apoptosis in various cells.
  • 基因功能參考文獻(xiàn):
    1. Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes PMID: 27816548
    2. ABCG1 and ABCG4 alter the distribution of gamma-secretase on the plasma membrane, leading to the decreased gamma-secretase activity and suppressed Abeta secretion PMID: 27196068
    3. Both the full-length and the short isoforms of ABCG1 can dimerize with ABCG4, whereas the ABCG2 multidrug transporter is unable to form a heterodimer with ABCG4. PMID: 27228027
    4. Study suggests that high ABCG4 expression is associated with poor prognosis in patients with non-small-cell lung cancer with advanced stages. PMID: 26270652
    5. HUWE1 and NEDD4-1 are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 and ABCG4 protein levels and cellular cholesterol export activity PMID: 26296893
    6. These results suggest that ABCA1, ABCG1, and ABCG4 are localized to distinct membrane meso-domains and disturb the meso-domain structures by reorganizing lipids on the plasma membrane PMID: 25302608
    7. This study demonstreated that Abcg4 acts in concert with Abcg2 to efflux Abeta from the brain across the blood-brain barrier. PMID: 22391220
    8. Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4: maps to human chromosome 11, is expressed abundantly in brain, and has alternatively-spliced isoforms PMID: 11856881
    9. ABCG4 is expressed specifically in the brain and the eye. PMID: 12183068
    10. ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles PMID: 16902247
    11. ABCG4 is highly expressed in microglia on alzheimer disease brain. PMID: 18508037
    12. Human ABC transporters ABCG2 (BCRP) and ABCG4 PMID: 18668433
    13. ABCG4 may be involved in macrophage lipid homeostasis. PMID: 11606068

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
  • 蛋白家族:
    ABC transporter superfamily, ABCG family, Eye pigment precursor importer (TC 3.A.1.204) subfamily
  • 組織特異性:
    Expressed specifically in the brain and the eye.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 13884

    OMIM: 607784

    KEGG: hsa:64137

    STRING: 9606.ENSP00000304111

    UniGene: Hs.126378



主站蜘蛛池模板: 亚洲精品午夜理伦不卡在线观看| 无码熟妇人妻av| 玩弄japan白嫩少妇hd小说| 久热国产vs视频在线观看| 失禁潮痉挛潮喷av在线无码| 国产精品 亚洲一区二区三区| 日本japanese丰满多毛| 亚洲欧美国产免费综合视频| 婷婷五月综合激情| 久久久久久人妻一区精品| 亚洲精品久久7777777国产| 夜夜揉揉日日人人| 成人无码av片在线观看| 国产98在线 | 日韩| 午夜婷婷精品午夜无码a片影院| 无码人妻专区免费视频| 中国女人内谢69xxxx免费视频| 国产午夜福利在线观看视频| 久久国产精品成人影院| 孕妇怀孕高潮潮喷视频孕妇 | 亚洲日韩av片在线观看| 日本少妇内射视频播放舔| 久久中文骚妇内射| 无套内内射视频网站| 狠狠色噜噜狠狠狠狠av不卡| 国产成人8x人在线视频软件| 天天躁夜夜躁狠狠综合2020| 中文字幕人妻无码一夲道| 免费观看羞羞视频网站| 国产无夜激无码av毛片| av国産精品毛片一区二区视频| 成人区人妻精品一区二区三区 | 国产激情综合在线看| 国产新婚夫妇叫床声不断| 精品国偷自产在线| 中文日韩亚洲欧美制服| 18禁止观看强奷免费国产大片| 国产欧美精品一区二区三区| 影音先锋在线资源无码| 3d动漫精品啪啪一区二区中| 欧美3p两根一起进高清视频 |