在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Human 5-hydroxytryptamine receptor 2B (HTR2B)

Recombinant Human 5-hydroxytryptamine receptor 2B (HTR2B)

  • 中文名稱：
    人HTR2B重組蛋白
  • 貨號：
    CSB-CF010888HU
  • 規格：
    ￥9720
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    HTR2B; 5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; Serotonin receptor 2B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 來源：
    in vitro E.coli expression system
  • 分子量：
    70.3kDa
  • 表達區域：
    1-481aa
  • 氨基酸序列
    MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
  • 基因功能參考文獻：
    1. The biological role of 5-HT2B which may act not only as a neurotransmitter receptor. PMID: 29379077
    2. The 3.0-A resolution structure of a complex between the human 5-hydroxytryptamine 2B (5-HT2B) receptor and an antibody Fab fragment bound to the extracellular side of the receptor reveals the mechanism of selectivity in extracellular recognition of the receptor by monoclonal antibodies. PMID: 28716900
    3. MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC. PMID: 27301951
    4. The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin sensitivity among HTR2B Q20* carriers with low testosterone levels. PMID: 27420381
    5. Study describes the crystal structure of Lysergic acid diethylamide (LSD) in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational selectivity of LSD's key diethylamide moiety. PMID: 28129538
    6. The 5-HT2B receptor may contribute to the regulation of human glucagon and glucose homeostasis and the interplay between glucagon and insulin secretion. PMID: 27437919
    7. Authors hypothesize that HTR2B expression in the infarcted territory may render degenerating neurons susceptible to attack by activated microglia and thus aggravate the consequences of stroke. PMID: 27013593
    8. Activation of 5-HT2B receptors stimulates GSIS in beta cells by triggering downstream changes in cellular Ca(2+) flux that enhance mitochondrial metabolism. PMID: 26733006
    9. the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in amyotrophic lateral sclerosis PMID: 26744351
    10. Studies have found that the HTR2B Q20* connected with impulsive behavior and cognitive impulsivity. PMID: 26575222
    11. Data indicate that hydrogen bonding interactions with Ser3.36 and Thr3.37 were important for isoflurane binding with the 5HT2B receptor. PMID: 24365264
    12. results of the present study suggest that the HTR2B polymorphism is not likely to be associated with personality traits, including novelty seeking and impulsivity. PMID: 23774082
    13. a new and unanticipated role of the 5-HT2B receptor N terminus as a negative modulator, affecting both constitutive and agonist-stimulated activity. PMID: 24174497
    14. study determined the crystal structure of the 5-HT2B receptor bound to ergotamine (ERG) and compared it with the 5-HT1B/ERG structure PMID: 23519215
    15. Serotonin skews human macrophage polarization through HTR2B and HTR7. PMID: 23355731
    16. The HTR2B gene may play little or no role in the development of Tourette syndrome. PMID: 22917605
    17. Genetic variants in HTR2B and TPH1 were not associated with the risk of GDM. PMID: 21836641
    18. Study confirms expression of transgenic 5-HT2b receptors in astrocytes freshly dissociated from mouse brain, isolated by fluorescence-activated cell sorting (FACS) and investigated in cultured cells. PMID: 20846463
    19. indicates a role for HTR2B in impulsivity PMID: 21179162
    20. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment PMID: 20564397
    21. The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis. PMID: 11859080
    22. the excitatory effects of 5-HT in human colon are mediated by 5-HT(2B) receptors. 5-HT(2B) receptors contribute to the putative 5-HT-induced colonic smooth muscle hypersensitivity associated with irritable bowel syndrome. PMID: 11877320
    23. Expression in cultured skin cells. PMID: 12767050
    24. 5-HT2B single nucleotide polymorphisms have significant association with substance-related disorders. PMID: 15608559
    25. Interactions between AT(1) and 5-HT(2B) receptors coexpressed by noncardiomyocytes are limiting key events in adrenergic agonist-induced, angiotensin-dependent cardiac hypertrophy. PMID: 19023134

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
  • 數據庫鏈接：

    HGNC: 5294

    OMIM: 601122

    KEGG: hsa:3357

    STRING: 9606.ENSP00000258400

    UniGene: Hs.421649



主站蜘蛛池模板： 蜜桃av蜜臀av色欲av麻| 精品乱人伦一区二区三区 | 强奷乱码中文字幕熟女导航| 人妻互换 综合| 欧美牲交a欧美牲交aⅴ另类| 日韩人妻无码免费视频一二区| 欲色欲色天天天www| 中文精品久久久久人妻不卡| 经典国产乱子伦精品视频| 国产亚洲人成在线播放| 一区二区伊人久久大杳蕉| 伊人久久精品无码麻豆一区| 国产人久久人人人人爽| 人妻被按摩师玩弄到潮喷| 亚洲午夜成人精品无码app| 国产女人叫床高潮大片| 国产又大又硬又粗| 色爱区综合五月激情| 果冻传媒mv免费播放在线观看| 亚洲熟女av乱码在线观看漫画| 国产涩涩视频在线观看| 香港三级日本三级a视频| 国产欧美日韩综合在线成| 情侣激情18内射骚话国产 | 女人喷液抽搐高潮视频| 高清国产一区二区三区在线| 国产精品aⅴ在线观看| 欧美放荡的少妇| 欧美俄罗斯乱妇| 18禁黄无遮挡网站免费| 18禁超污无遮挡无码网址| 丰满多毛少妇做爰视频爽爽和| 久久丫精品忘忧草西安产品| 日本丰满熟妇bbxbbxhd| 国产日韩亚洲大尺度高清 | 精品无码一区二区三区电影| 欧美人与禽zozzo性伦交| 欧美熟妇性xxx交潮喷| 免费无码又爽又刺激高潮视频| 国产天堂久久天堂av色综合| 最近最好的中文字幕2019免费 |