在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Escherichia coli Regulator of sigma E protease (rseP)

  • 中文名稱:
    大腸桿菌rseP重組蛋白
  • 貨號:
    CSB-CF365147ENV
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    rseP
  • Uniprot No.:
  • 別名:
    rseP; ecfE; yaeL; b0176; JW0171; Regulator of sigma-E protease RseP; S2P endopeptidase; Site-2 protease RseP; S2P protease RseP; Site-2-type intramembrane protease
  • 種屬:
    Escherichia coli (strain K12)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-450
  • 氨基酸序列
    MLSFLWDLASFIVALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDKLGTEYV IALIPLGGYVKMLDERAEPVVPELRHHAFNNKSVGQRAAIIAAGPVANFIFAIFAYWLVF IIGVPGVRPVVGEIAANSIAAEAQIAPGTELKAVDGIETPDWDAVRLQLVDKIGDESTTI TVAPFGSDQRRDVKLDLRHWAFEPDKEDPVSSLGIRPRGPQIEPVLENVQPNSAASKAGL QAGDRIVKVDGQPLTQWVTFVMLVRDNPGKSLALEIERQGSPLSLTLIPESKPGNGKAIG FVGIEPKVIPLPDEYKVVRQYGPFNAIVEATDKTWQLMKLTVSMLGKLITGDVKLNNLSG PISIAKGAGMTAELGVVYYLPFLALISVNLGIINLFPLPVLDGGHLLFLAIEKIKGGPVS ERVQDFCYRIGSILLVLLMGLALFNDFSRL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue 'Val-148' of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamase, OmpF, LivK, SecM, PhoA, LivJ, OmpC, Lpp and TorA, probably within the membrane.
  • 基因功能參考文獻:
    1. we describe several methods for characterization of the proteolytic functions and structure of RseP mainly in vivo, including a proteolytic activity assay using model substrates, an in vitro analysis of cleavage of signal peptides in a detergent solution and in the membrane vesicles, structural analysis of membrane-embedded RseP based on the thiol modifiability of introduced cysteine residues, and the protein interaction PMID: 28065260
    2. Mutations disturbing the possible beta-strand conformation of the loop impaired RseP proteolytic activity and that some of these mutations resulted in the differential cleavage of different substrates. PMID: 26447507
    3. study concludes that recognition of the cleaved amino acid by the RseP PDZ domain is not essential for sequential cleavage of RseA and sigma(E) stress response in vivo PMID: 23016873
    4. Escherichia coli RseP, an site-2 protease (S2P) family I-CLiP, introduces a cleavage into signal peptides after their signal peptidase-mediated liberation from preproteins PMID: 21810987
    5. RseP, which is required for normal sigmaE activation, prevents toxicity due to the presence of two specific outer membrane proteins that are down-regulated by RseX PMID: 16513633
    6. RseP catalyzes proteolytic cleavage of the membrane-bound anti-sigma(E) protein RseA as an essential step in transmembrane signal transduction in the sigma(E) extracytoplasmic stress response pathway. PMID: 18268014
    7. circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of Escherichia coli PMID: 18945679
    8. after DegS cleavage, the newly exposed carboxyl terminus of RseA may facilitate Site-2 cleavage through direct interaction with the PDZ domain. PMID: 19706448

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell inner membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Peptidase M50B family
  • 數據庫鏈接:


主站蜘蛛池模板: 国语少妇高潮对白在线| 四虎国产精品永久地址49| 国产热re99久久6国产精品首页 | 日日鲁鲁鲁夜夜爽爽狠狠 | 国产在线观看精品一区二区三区| 各种少妇正面bbw撒尿| 成熟老妇女毛茸茸的做性| 国产第一页浮力影院入口| 国产精品美女久久久久久久 | 国产女人乱子对白av片| 久久精品囯产精品亚洲| 国产成人av免费观看| 亚洲码欧美码一区二区三区 | 羞涩的丰满人妻40p| 国产三级在线观看免费| 女人高潮流白浆视频| 国产精品久久久久久人妻精品| 国产精品天干天干在线综合| 国内精品久久久久久影院| 久久久久久九九99精品| 精品一二三区久久aaa片| 日产精品中文一区二区三区| 久久视频这里只精品| 免费看男女做爰爽爽视频| 国产精品久久久久9999爆乳| 自拍偷自拍亚洲精品第1页| 久久毛片免费看一区二区三区| 国产日产欧产精品精品| 国产精品免费观看久久| 蜜桃视频无码区在线观看| 亚洲人成77777在线播放网站不卡 国产 | 欧洲野花视频天堂视频p 亚洲aⅴ天堂av天堂无码 | 国产精品人妻熟女男人的天堂| 久久精品无码一区二区app| 久久综合88熟人妻| 国产又大又黑又粗免费视频| 中文字幕av无码一二三区电影| 夜夜澡天天碰人人爱av| 人妻少妇精品专区性色av| 国产精品成人免费一区久久羞羞 | 日本一卡2卡3卡4卡免费乱码网站| 无码人妻aⅴ一区二区三区玉蒲团|