在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Drosophila melanogaster Tafazzin homolog (Taz)

  • 中文名稱:
    黑腹果蠅Taz重組蛋白
  • 貨號:
    CSB-CF893713DLU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Taz
  • Uniprot No.:
  • 別名:
    Taz; CG8766; Tafazzin; TAZ; dTAZ
  • 種屬:
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-378
  • 氨基酸序列
    MFMVVCSNLRRPGHVGAASAARNINWLISEGYTPPIRAMARPYVQAPEARPVPDERYPGS QQDRKDIATQTVRSSKPKDLRPPSPPTPSQTLNSSSLPPPMSDQDADPSLDVPTGVAMPY NIDWIFPRLRNPSKFWYVVSQFVVSAVGIFSKVVLMFLNKPRVYNRERLIQLITKRPKGI PLVTVSNHYSCFDDPGLWGCLPLGIVCNTYKIRWSMAAHDICFTNKLHSLFFMFGKCIPV VRGIGVYQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYESPKIPIILP MWHEGMDDLLPNVEPYVIQRGKQVTLNVGQPLDLNDFILDLKKRQVPEPTARKLITDKIQ EAFRDLRAETEKLHRERN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function. Remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms. This makes CL critical for the coassembly of lipids and proteins in mitochondrial membranes. Catalyzes the transacylacion between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes. Essential for the final stage of spermatogenesis, spermatid individualization. Required for the initiation of mitophagy.
  • 基因功能參考文獻:
    1. propose that tafazzin reacts with non-bilayer-type lipid domains that occur in curved or hemifused membrane zones and that acyl specificity is driven by the packing properties of these domains PMID: 22941046
    2. Data show that tafazzin mutations in Drosophila generate a Barth-related phenotype, with the triad of abnormal cardiolipin, pathologic mitochondria, and motor weakness, suggesting causal links between these findings. PMID: 16855048
    3. Drosophila tafazzin is a CoA-independent, acyl-specific phospholipid transacylase with substrate preference for cardiolipin and phosphatidylcholine PMID: 17082194
    4. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation. PMID: 19114128
    5. tafazzin deficiency in Drosophila disrupts the final stage of spermatogenesis, spermatid individualization, and causes male sterility PMID: 19164547
    6. the characteristic fatty acid profile of cardiolipin is not determined by the substrate specificity of tafazzin PMID: 19700766

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion.; [Isoform A]: Mitochondrion membrane.; [Isoform B]: Mitochondrion membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane.; [Isoform C]: Mitochondrion membrane.
  • 蛋白家族:
    Taffazin family
  • 數(shù)據(jù)庫鏈接:

    KEGG: dme:Dmel_CG8766

    STRING: 7227.FBpp0086975

    UniGene: Dm.6762



主站蜘蛛池模板: 久久综合色老色| 欧美交a欧美精品喷水| 最新69国产成人精品视频| 亚洲精品午夜一区二区电影院| 小宝极品内射国产在线| 福利姬液液酱喷水| 亚洲夜色噜噜av在线观看| 国产成人亚洲综合色婷婷秒播| 亚洲国产一区二区a毛片| 99久久久国产精品免费蜜臀| 亚洲视频日本有码中文| 688欧美人禽杂交狂配| 男人添女人囗交做爰视频| 一色屋精品视频在线观看| 亚洲另类自拍丝袜第五页| 中文字幕va一区二区三区 | 四川少妇被弄到高潮| 亚洲男人综合久久综合天堂| 亚洲精品国产一区二区的区别| 亚洲www啪成人一区二区麻豆| 国色天香天天影院综合网 | 特殊重囗味sm在线观看无码| 久久综合亚洲欧美成人| 亚洲精品欧美二区三区中文字幕| 久久人人爽人人爽人人爽| 国产清纯美女爆白浆视频| 少妇大叫太大太爽受不了| 美女裸体无遮挡免费视频网站| 国产亚洲综合网曝门系列| 最新亚洲一卡二卡三卡四卡| 国产成人精品无码播放| 成人3d动漫一区二区三区| 成人麻豆亚洲综合无码精品 | 国产精自产拍久久久久久蜜| 亚洲卡1卡2卡新区网站| 中日韩va无码中文字幕| 亚洲日韩久久综合中文字幕 | 中日韩产精品1卡二卡三卡| 狠狠躁夜夜躁人人爽超碰97香蕉| 日本高清www午色夜在线视频 | 国产精品爽黄69天堂a|