在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Drosophila melanogaster Tafazzin homolog (Taz)

  • 中文名稱:
    黑腹果蠅Taz重組蛋白
  • 貨號:
    CSB-CF893713DLU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Taz
  • Uniprot No.:
  • 別名:
    Taz; CG8766; Tafazzin; TAZ; dTAZ
  • 種屬:
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-378
  • 氨基酸序列
    MFMVVCSNLRRPGHVGAASAARNINWLISEGYTPPIRAMARPYVQAPEARPVPDERYPGS QQDRKDIATQTVRSSKPKDLRPPSPPTPSQTLNSSSLPPPMSDQDADPSLDVPTGVAMPY NIDWIFPRLRNPSKFWYVVSQFVVSAVGIFSKVVLMFLNKPRVYNRERLIQLITKRPKGI PLVTVSNHYSCFDDPGLWGCLPLGIVCNTYKIRWSMAAHDICFTNKLHSLFFMFGKCIPV VRGIGVYQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYESPKIPIILP MWHEGMDDLLPNVEPYVIQRGKQVTLNVGQPLDLNDFILDLKKRQVPEPTARKLITDKIQ EAFRDLRAETEKLHRERN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function. Remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms. This makes CL critical for the coassembly of lipids and proteins in mitochondrial membranes. Catalyzes the transacylacion between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes. Essential for the final stage of spermatogenesis, spermatid individualization. Required for the initiation of mitophagy.
  • 基因功能參考文獻:
    1. propose that tafazzin reacts with non-bilayer-type lipid domains that occur in curved or hemifused membrane zones and that acyl specificity is driven by the packing properties of these domains PMID: 22941046
    2. Data show that tafazzin mutations in Drosophila generate a Barth-related phenotype, with the triad of abnormal cardiolipin, pathologic mitochondria, and motor weakness, suggesting causal links between these findings. PMID: 16855048
    3. Drosophila tafazzin is a CoA-independent, acyl-specific phospholipid transacylase with substrate preference for cardiolipin and phosphatidylcholine PMID: 17082194
    4. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation. PMID: 19114128
    5. tafazzin deficiency in Drosophila disrupts the final stage of spermatogenesis, spermatid individualization, and causes male sterility PMID: 19164547
    6. the characteristic fatty acid profile of cardiolipin is not determined by the substrate specificity of tafazzin PMID: 19700766

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion.; [Isoform A]: Mitochondrion membrane.; [Isoform B]: Mitochondrion membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane.; [Isoform C]: Mitochondrion membrane.
  • 蛋白家族:
    Taffazin family
  • 數(shù)據(jù)庫鏈接:

    KEGG: dme:Dmel_CG8766

    STRING: 7227.FBpp0086975

    UniGene: Dm.6762



主站蜘蛛池模板: 性无码专区无码| 色婷婷av久久久久久久| 少妇无码av无码专区在线观看| 亚洲成av人在线视| 国产精品无码av天天爽播放器 | 亚洲色成人一区二区三区| 国产99视频精品免视看7| av无码一区二区三区| 亚洲熟悉妇女xxx妇女av| 人妻少妇精品视频无码综合| 国产97超碰人人做人人爱| 久久爱www人成狠狠爱综合网| 久久高清超碰av热热久久| 国产精品免费看久久久无码| 无码av一区二区三区无码| 亚洲精品蜜桃久久久久久| 国产一区二区三区在线蜜桃| av网站的免费观看| 在线 v亚洲 v欧美v 专区| 久本草在线中文字幕亚洲| 亚洲gv猛男gv无码男同 | 亚洲综合精品香蕉久久网| 免费观看一区二区三区| 成人免费看片又大又黄| 在线天堂新版最新版在线8| 天干天干夜啦天干天干国产 | 日产欧美国产日韩精品| 四库影院永久四虎精品国产| 麻豆国产一区二区三区四区| 黑森林福利视频导航| 黑人好猛厉害爽受不了好大撑| 亚洲最大av一区二区三区| 邪恶肉肉全彩色无遮盖| 五月婷婷久久草丁香| 久久国产精久久精产国| 狠狠色丁香婷婷综合尤物| 国产片av片永久免费观看| 九九re6热在线视频精品66| 性猛交ⅹxxx富婆视频| 青青草av一区二区三区| 天天躁日日躁狠狠躁性色av|