在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Drosophila melanogaster Frizzled-2 (fz2)

  • 中文名稱:
    黑腹果蠅fz2重組蛋白
  • 貨號:
    CSB-CF895666DLU
  • 說明書:
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    fz2
  • Uniprot No.:
  • 別名:
    fz2; CG9739; Frizzled-2; dFz2
  • 種屬:
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達(dá)區(qū)域:
    23-694
  • 氨基酸序列
    DGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSF PNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCER ARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGS GSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLI FLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIA LWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDG LLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHL AAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAG FVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFED WIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLG APDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVASTSHHHLH HHVLKQPAASHV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
  • 基因功能參考文獻(xiàn):
    1. Maturation of a central brain flight circuit in Drosophila requires Fz2 and Ca2+ signaling. PMID: 25955970
    2. Study finds that C-terminal fragments of the Wg receptor DFz2 accumulate in nuclear foci in association with large RNA granules localizing to the space between the inner & and outer nuclear membranes; granules are found at of inner membrane invaginations, are bounded by LamC, and can be seen leaving the nucleus. PMID: 22579286
    3. subcellular Fz localization, through the association with other membrane proteins, is a critical aspect in regulating the signaling specificity within the Wnt/Fz signaling pathways PMID: 15252441
    4. Frizzled2 achieves ligand capture and internalization, whereas Arrow, and perhaps downstream signalling, are essential for lysosomal targeting. PMID: 16291792
    5. DFz2 functions as an endocytic receptor for Wingless in the Drosophila wing PMID: 16530179
    6. Data show that GRIP is necessary for the trafficking of Frizzled-2 to the nucleus. PMID: 16682643

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor Fz/Smo family
  • 數(shù)據(jù)庫鏈接:

    KEGG: dme:Dmel_CG9739

    STRING: 7227.FBpp0303228

    UniGene: Dm.2524



主站蜘蛛池模板: 成人做爰www网站视频| 日韩av片无码一区二区不卡电影| 国产av一二三无码影片| 国产揄拍国产精品| 亚洲成a人片在线观看无码下载| av无码动漫一区二区三区精品| 丰满少妇高潮惨叫久久久| 风韵少妇性饥渴推油按摩视频| 小辣椒福利视频导航| 在线观看国产日韩亚洲中| 久久精品国产久精久精| 欧美另类videosbestsex日本| 人妻精品久久久久中文字幕| 麻婆豆传媒一区二区三区| 性xxxx欧美老妇506070| 天天射寡妇射| 伊人色综合网一区二区三区| 日韩精品电影综合区亚洲| ā片在线观看免费观看| 又粗又黄又硬又爽的免费视频| 少妇一边呻吟一边说使劲| 偷妻之寂寞难耐2中文字幕| 亚洲天堂男人影院| 欧美成人免费全部观看国产| 亚洲精品无码av人在线观看国产| 久久av无码精品人妻出轨| 亚洲的天堂av无码| 扒开双腿猛进入喷水高潮叫声| 色噜噜狠狠色综合av| 忍不住的亲子中文字幕| 18禁勿入午夜网站入口| 女人19水真多免费毛片| 国产精品久久久久9999爆乳| 久久九九久精品国产| 小鲜肉洗澡时自慰网站xnxx| 亚洲五月丁香综合视频| 欧美gv在线观看| 国产麻豆精品精东影业av网站| 夜夜高潮天天爽欧美| 久久高清内射无套| 婷婷色香五月综合缴缴情|