在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Dog Claudin-2 (CLDN2)

  • 中文名稱:
    Recombinant Dog Claudin-2(CLDN2)
  • 貨號:
    CSB-CF836096DO
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    CLDN2
  • Uniprot No.:
  • 別名:
    CLDN2; Claudin-2
  • 種屬:
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-230
  • 氨基酸序列
    MASLGLQLVGYILGLLGLLGTLVAMLLPSWRTSSYVGTSIVTAVGFSKGLWMECATHSTG ITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIVSVVGMRCTVFCQDSRAKDRLAVV GGVFFIIGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLVAGII LCFSCPLQGNRSDYYDSYQAQPLATRGSPRPGQPPKAKSEFNSYSLTGYV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻:
    1. hypotonic stress induces dephosphorylation, clathrin-dependent endocytosis, and degradation of claudin-1 and -2 in lysosomes, resulting in disruption of the TJ barrier in renal tubular epithelial cells. PMID: 27733684
    2. Claudin-2 independently determines the 'leaky' property of Tight Junctions in MDCK II cells. PMID: 25781928
    3. PKCiota binds to Rab14 and that PKCiota requires Rab14 for its correct distribution in cells. As with Rab14, PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier. PMID: 25694446
    4. IQGAP1 modulates TJ formation by a twofold mechanism: (1) controlling the expression and recruitment of claudin 2 and recruitment of claudin 4 to the TJ, and (2) transient inhibition of the CDC42-JNK pathway. PMID: 25588839
    5. These results suggest that hyperosmolarity decreases the expression level of claudin-2 via a decrease in PKCbeta-dependent GATA-2 transcriptional activity in renal tubular epithelial cells PMID: 25825272
    6. These results implicate Rab14 in specialized trafficking of claudin-2 from the recycling endosome. PMID: 24694596
    7. these results indicate that EGF controls the levels of CLDN-2 and -4 proteins and mRNAs through Src and STAT3 activity. PMID: 24909426
    8. YM201636 treatment blocks the continuous recycling of claudin-1/claudin-2 and delays epithelial barrier formation PMID: 22396724
    9. Epidermal growth factor accelerates clathrin-dependent endocytosis and lysosomal degradation of CLDN2 protein. PMID: 21660968
    10. These results suggest that the decrease in claudin-2 expression enhances cell migration mediated by the increase in the expression and activity of MMP-9. PMID: 20717932
    11. the ERK 1/2 signaling pathway negatively controls claudin-2 expression in mammalian renal epithelial cells and provide evidence for regulation of tight junction paracellular transport by alterations in claudin composition within tight junction complexes. PMID: 15569684
    12. These results provide novel insights about the mechanisms of cingulin function and the signaling pathways controlling claudin-2 expression in Madin-Darby canine kidney (MDCK) cells. PMID: 16723500
    13. Claudin-2 expression markedly increased in the proximal crypt and luminal colonic epithelium in affected dogs, suggesting a role in the pathogenesis of canine LPC. PMID: 17595339
    14. The discovery of claudin 2 transcript and protein in the skin could be of importance in epidermal differentiation, barrier function and pathological conditions. PMID: 18509255
    15. LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and the turnover of tight junctions is regulated by ubiquitylation. PMID: 19295125
    16. Report downregulation of claudin-2 expression in renal epithelial cells by metabolic acidosis. PMID: 19587148

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Claudin family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 久久精品中文字幕第一页| 国产好大好硬好爽免费不卡| 中文人妻无码一区二区三区信息 | 久久成人网站亚洲综合| 国产欧美成人一区二区a片| 99久久婷婷国产综合精品青草免费| 妺妺窝人体色www在线| 午夜私人成年影院在线观看| 免费女人18毛片a毛片视频| 国产又粗又猛又爽又黄| 日本极品少妇xxxx| 日韩精品人妻无码久久影院| 国产亚洲日韩一区二区三区| 性色av免费网站| 日韩综合无码一区二区| 亚洲国产精品无码中文字满| 国产精品亚洲а∨天堂| 一本一久本久a久久精品综合| 国产极品视觉盛宴| 国产精品久久久久久妇女| 掀开奶罩边吃边摸下娇喘视频 | 浓毛欧美老妇乱子伦视频| 国产成人精品一区二区在线小狼| 少妇白浆高潮无码免费区| 国产成人综合在线女婷五月99播放| 亚洲国产精品va在线观看麻豆| 青青草视频免费观看| 夜夜未满十八勿进的爽爽影院| 久久久久蜜桃精品成人片| 久久成人网站亚洲综合| 国产精品亚韩精品无码a在线 | 4399理论片午午伦夜理片| 无码av免费毛片一区二区| 双腿高潮抽搐喷白浆视频| 野外做受又硬又粗又大视幕| 亚洲夜夜性无码| 真人做作爱视频| 免费啪视频在线观看视频网页| 久久国产中文娱乐网| 成人aa免费视频在线播放| 久爱www人成免费网站|