在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Cricetulus griseus Insulin-induced gene 1 protein (INSIG1)

  • 中文名稱:
    Recombinant Cricetulus griseus Insulin-induced gene 1 protein(INSIG1)
  • 貨號:
    CSB-CF807010DXU
  • 說明書:
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    INSIG1
  • Uniprot No.:
  • 別名:
    INSIG1; Insulin-induced gene 1 protein; INSIG-1
  • 種屬:
    Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-257
  • 氨基酸序列
    MPRLHDHVWSCSGSGAARPHSLPRGMIAAARCPQGSGAPEPAPRSPRAGTAGCGARPGSW HHDLVQRSLVLFSFGVVLALVLNLLQIQRNVTLFPDEVIATIFSSAWWVPPCCGTAAAVV GLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGL WWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVG NIGRQLAMGVPEKPHSD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139. Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78.
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    INSIG family
  • 數據庫鏈接:


主站蜘蛛池模板: 日韩av高清在线观看| 免费很黄无遮挡的视频| 天天干天天日夜夜操| 在厨房拨开内裤进入毛片| 深夜国产一区二区三区在线看| 精品国产一区二区三区av片| 无人去码一码二码三码区| 中文字幕乱码熟女人妻水蜜桃| 少妇无码一区二区三区| 欧美成人精精品一区二区| 中文字幕av无码免费一区| 成人做爰69片免费看网站野花| 亚洲乱亚洲乱妇小说网| 两个美女裸体舌吻互扒内裤| 亚洲色中文字幕在线播放| 精品无码专区毛片| 中国凸偷窥xxxx自由视频妇科| 麻豆精品一卡二卡三卡| 真人一进一出120秒试看| 欧美成人一区二区三区在线观看| 极品少妇被后入内射视| 色综合 图片区 小说区| 亚洲人成电影在线天堂色 | 欧美精欧美乱码一二三四区 | 成人做爰www网站视频下载| 午夜视频体内射.com.com| 两个人日本www免费版| 天码欧美日本一道免费| 一本大道东京热无码| 成在线人免费视频一区二区| 国产白嫩护士在线播放| 99热在线精品国产观看| 一个人看的日本hd免费| 亚洲综合av色婷婷| 久久综合国产乱子伦精品免费| 丝袜美腿一区二区三区| 少妇内射视频播放舔大片| 亚洲综合无码av一区二区三区 | 国产精品国产高清国产av| 少妇被粗大的猛烈进出图片| 久久狼人大香伊蕉国产|