在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Cricetulus griseus Insulin-induced gene 1 protein (INSIG1)

  • 中文名稱:
    Recombinant Cricetulus griseus Insulin-induced gene 1 protein(INSIG1)
  • 貨號:
    CSB-CF807010DXU
  • 說明書:
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    INSIG1
  • Uniprot No.:
  • 別名:
    INSIG1; Insulin-induced gene 1 protein; INSIG-1
  • 種屬:
    Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-257
  • 氨基酸序列
    MPRLHDHVWSCSGSGAARPHSLPRGMIAAARCPQGSGAPEPAPRSPRAGTAGCGARPGSW HHDLVQRSLVLFSFGVVLALVLNLLQIQRNVTLFPDEVIATIFSSAWWVPPCCGTAAAVV GLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGL WWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVG NIGRQLAMGVPEKPHSD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139. Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78.
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    INSIG family
  • 數據庫鏈接:


主站蜘蛛池模板: 中文字幕无码专区一va亚洲v专区在线| 久久成人麻豆午夜电影| 无码av免费毛片一区二区| 久久这里只精品国产免费9| 最新精品国偷自产在线老年人| 亚洲精品乱码久久久久久中文字幕| 国产sm调教折磨视频| 亚洲熟女精品中文字幕| 男女做爰猛烈啪啪吃奶动 | 日本人又黄又爽又色的视频| 偷拍农村老熟妇xxxxx7视频| 久久精品www人人爽人人| 人妻少妇被猛烈进入中文字幕| 色欲天天婬色婬香综合网完整版| 国产精品久久久久久久伊一| 大肉大捧一进一出好爽视色大师| 亚洲乱码中文字幕在线| 欧美猛少妇色xxxxx猛交| 亚洲精品一卡2卡三卡4卡| 婷婷亚洲综合五月天小说| 亚洲精品午夜无码专区| 大陆国产乱人伦| 无码一区二区三区久久精品| 国产一区二区| 人人人爽人人爽人人av| 97久久超碰国产精品旧版麻豆| 国内露脸少妇精品视频| 色综合久久久久无码专区| 变态另类牲交乱| 国产九九九九九九九a片| 日韩成av人片在线观看| 亚洲日韩国产精品乱-久| 国内精品伊人久久久久av影院| 18禁在线永久免费观看| 亚洲一区在线日韩在线秋葵 | 午夜一区二区亚洲福利| 丰满人妻熟妇乱偷人无码| 在线观看一区二区三区国产免费| 成人伊人亚洲人综合网| 邻居少妇张开腿让我爽了在线观看| 成人区精品一区二区婷婷|