在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Bovine ADP/ATP translocase 1 (SLC25A4)

  • 中文名稱:
    牛SLC25A4重組蛋白
  • 貨號:
    CSB-CF021510BO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    SLC25A4; AAC1; ANT1; ADP/ATP translocase 1; ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart isoform T1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4
  • 種屬:
    Bos taurus (Bovine)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-298
  • 氨基酸序列
    SDQALSFLKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRI PKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASGG AAGATSLCFVYPLDFARTRLAADVGKGAAQREFTGLGNCITKIFKSDGLRGLYQGFNVSV QGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQTVTAVAGLVSYPFDTVRRRMMMQ SGRKGADIMYTGTVDCWRKIAKDEGPKAFFKGAWSNVLRGMGGAFVLVLYDEIKKFV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Probably mediates mitochondrial uncoupling in tissues that do not express UCP1. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it. Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1.
  • 基因功能參考文獻:
    1. Data show that the binding sites on adenine nucleotide translocator 1 (ANT1) have an affinity for cardiolipin (CL). PMID: 27786441
    2. Phosphatidic acid and cardiolipin interact with the mitochondrial ADP/ATP carrier. PMID: 19902971
    3. Crystal form of ADP/ATP carrier obtained in the presence of carboxyatractyloside was analysed. PMID: 16226253
  • 亞細胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性:
    Detected in heart muscle (at protein level). Detected in heart.
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲精品乱码久久久久久日本麻豆| 亚欧成人无码av在线播放| 婷婷色怡春院| 中文字幕无码日韩中文字幕| 又大又硬又爽免费视频| 粗了大了 整进去好爽视频| 先锋影音xfyy5566男人资源| 午夜精品久久久久9999| 欧美亚洲另类丝袜综合网| 久久精品国产亚洲αv忘忧草| 欧美 日韩 国产 成人 在线观看| 激情内射人妻1区2区3区| 丰满少妇高潮惨叫久久久一| 欧美性xxxx极品hd欧美风情| 深夜爽爽动态图无遮无挡| 欧美丰满熟妇bbb久久久| 国产精品久久人妻无码网站一区| 日本高清视频www| yyyy11111少妇影院| 国产精品午夜视频自在拍| 又白又嫩毛又多15p| 高清偷自拍第1页| 老司机无码精品a| 国产超碰人人爽人人做av| 少妇午夜av一区| 国产成人一区二区三区| 成人影片麻豆国产影片免费观看| 乱人伦无码中文视频在线| 久久99er6热线精品首页| 国产精品中文久久久久久久 | 亚洲 制服 丝袜 无码 在线| 亚洲一区二区三区四区| 无码免费无线观看在线视频| 国产α片免费观看在线人 | 在线看片国产日韩欧美亚洲| 窝窝午夜色视频国产精品破| 无码一区二区波多野结衣播放搜索 | 18禁裸男晨勃露j毛网站| 国产三级做爰在线播放| 国产成人精品a视频| 免费无码成人av在线播|