在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CT26/Human CCR8 Stable Cell Line

  • 貨號:
    CSB-SC004847HU3
  • 規格:
    1 vial contains approximately 5x106 cells in 1 ml
  • 價格:
    ¥30000
  • 活性:
    • Untransfected CT26 cells (green line) and transfected Human CCR8 CT26 Stable cells (red line) were stained with anti-CCR8 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
  • 其他:

產品詳情

  • Uniprot No.:
  • 生長類型:
    Adherent
  • 抗性:
    Puromycin
  • 培養基:
    RPMI 1640 + 10% FBS + 10μg/mL Puromycin
  • 別名:
    CCR8
  • 蛋白標簽:
    Tag-Free
  • 保存緩沖液:
    35% FBS + 55% RPMI 1640 + 10% DMSO
  • 應用范圍:
    Binding assay by FACS and cell based ELISA.
  • 儲存條件:
    Frozen in liquid nitrogen or stored at -80°C
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

靶點詳情

  • 功能:
    Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
  • 基因功能參考文獻:
    1. Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
    2. Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
    3. High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
    4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
    5. Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
    6. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
    7. Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
    8. CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
    9. Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
    10. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
    11. The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
    12. There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
    13. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
    14. found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
    15. CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
    16. Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
    17. The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
    18. the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
    19. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
    20. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
    21. CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
    22. The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:

    HGNC: 1609

    OMIM: 601834

    KEGG: hsa:1237

    STRING: 9606.ENSP00000326432

    UniGene: Hs.113222



主站蜘蛛池模板: 中文字幕人妻无码专区| 曰的好深好爽免费视频网站| 成人夜色视频网站在线观看| 色午夜日本高清视频www| 无码伊人66久久大杳蕉网站谷歌| 久久人人爽爽人人爽人人片av| av无码一区二区三区| 人妻内射一区二区在线视频| 亚洲精品专区在线观看| 亚洲经典国产精华液单品榜| 成人av片在线观看免费| 日韩欧美在线综合网另类| 五月婷婷开心中文字幕| 国产又猛又黄又爽| 亚洲欧美另类成人综合图片| 国产 成人 综合 亚洲 网站| 男女啪啪进出阳道猛进| 国产av一区最新精品| 久久精品亚洲一区二区三区浴池| 国产欧美在线一区二区三| 久久只有这里有精品4| 夫妻免费无码v看片| 天躁夜夜躁狼狠躁| 亚洲s色大片在线观看| 中文av岛国无码免费播放| 在线视+欧美+亚洲日本| 大肉大捧一进一出好爽| 无码av免费毛片一区二区 | 中文字幕精品av乱码在线| 无码国产69精品久久久孕妇| 国产亚洲精品久久久久久大师| 久久熟妇人妻午夜寂寞影院| 超清精品丝袜国产自在线拍| 艳妇荡女欲乱双飞两中年熟妇| 午夜不卡久久精品无码免费| 欧美孕妇乳喷奶水在线观看| 99国产成人精品视频| 国产黄在线观看免费观看软件| 高清中文字幕在线a片| 香蕉精品亚洲二区在线观看| 亚洲成av人片天堂网九九|