在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant human Trichohyalin (TCHH), partial

In Stock
  • 中文名稱:
    人TCHH重組蛋白
  • 貨號:
    CSB-EP023309HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    TCHH
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    18.6 kDa
  • 表達區域:
    1854-1943aa
  • 氨基酸序列
    QEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQYRP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.
  • 基因功能參考文獻:
    1. The difference between the twoinduced pluripotent stem cell(IPSC) clones in TCHH methylation did not have an obvious effect on its expression in 3D human epidermal equivalent, suggesting that differentiation and tissue formation may mitigate variations in the iPSC methylome. PMID: 27460132
    2. To evaluate the relative contribution of these variants, we performed a second genome-wide scan in 709 samples from the Uyghur, an admixed population with both eastern and western Eurasian ancestries. In Uyghurs, both EDAR (rs3827760: P = 1.92 x 10(-12)) and TCHH (rs11803731: P = 1.46 x 10(-3)) are associated with hair straightness, but EDAR (OR 0.415) has a greater effect than TCHH (OR 0.575). PMID: 27487801
    3. Data suggest that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder. PMID: 20722389
    4. BMP-4 signalling activates AHF transcription in hair follicles. PMID: 18643848
    5. In human keratinocytes, we found BMP-4 facilitates trichohyalin (THH) transcription, and lamin C plays a key role in the posttranslational stabilization of THH. PMID: 18643848
    6. Common variants in the TCHH gene are associated with straight hair in Europeans. PMID: 19896111

    顯示更多

    收起更多

  • 相關疾病:
    Uncombable hair syndrome 3 (UHS3)
  • 蛋白家族:
    S100-fused protein family
  • 組織特異性:
    Found in the hard keratinizing tissues such as the inner root sheath (IRS) of hair follicles and medulla, and in the filiform papillae of dorsal tongue epithelium.
  • 數據庫鏈接:

    HGNC: 11791

    OMIM: 190370

    KEGG: hsa:7062

    STRING: 9606.ENSP00000357794

    UniGene: Hs.432416



主站蜘蛛池模板: 天天综合网亚在线| 东京道一本热中文字幕| 久久综合给合久久狠狠狠88 | 亚洲第一无码xxxxxx| 国精产品一区一区三区有限公司杨| 国产人妻高清国产拍精品| 天天爽天天狠久久久综合麻豆 | 成年女人永久免费观看视频| 久久视频在线视频| 国产高清乱理伦片| 国产1卡2卡三卡四卡精品| 亚洲夜夜性无码| 骚虎视频在线观看| 亚洲综合无码av一区二区三区 | 色狠狠av老熟女| 久久96国产精品久久久| 亚洲视频无码高清在线| 成人国产精品一区二区免费看 | 国产成人精品日本亚洲77上位| 亚洲色无码专区在线播放| 国语少妇高潮对白在线| 高清不卡一区二区三区| 亚洲国产精品久久久久久| 大陆国产乱人伦| 国产女女做受ⅹxx高潮| 亚洲国产aⅴ成人精品无吗| 新版天堂资源中文www连接| 中文字幕人妻丝袜成熟乱 | 一区二区三区人妻无码| 麻花传媒剧国产mv高清播放| 67pao国产成视频永久免费| 久久婷婷五月综合97色一本一本| 与子敌伦刺激对白播放的优点| 亚洲综合无码av一区二区三区| 国产香蕉97碰碰久久人人| 精品人妻无码专区中文字幕 | 亚洲伊人成无码综合影院| 亚洲 欧美 综合 另类 中字| 香蕉久久久久久久av网站| 啪啪激情婷婷久久婷婷色五月 | 国产精品福利视频萌白酱|