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  4. Recombinant Xenopus laevis DNA replication factor Cdt1 (cdt1), partial

Recombinant Xenopus laevis DNA replication factor Cdt1 (cdt1), partial

  • 中文名稱(chēng)：
    Recombinant Xenopus laevis DNA replication factor Cdt1(cdt1) ,partial
  • 貨號(hào)：
    CSB-YP872776XBE
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    Recombinant Xenopus laevis DNA replication factor Cdt1(cdt1) ,partial
  • 貨號(hào)：
    CSB-EP872776XBE
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    Recombinant Xenopus laevis DNA replication factor Cdt1(cdt1) ,partial
  • 貨號(hào)：
    CSB-EP872776XBE-B
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    Recombinant Xenopus laevis DNA replication factor Cdt1(cdt1) ,partial
  • 貨號(hào)：
    CSB-BP872776XBE
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    Recombinant Xenopus laevis DNA replication factor Cdt1(cdt1) ,partial
  • 貨號(hào)：
    CSB-MP872776XBE
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    cdt1
  • Uniprot No.：
  • 別名：
    cdt1; DNA replication factor Cdt1; XCDT1
  • 種屬：
    Xenopus laevis (African clawed frog)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with cdc6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication.
  • 基因功能參考文獻(xiàn)：
    1. The results showed that the Cdt1 region spanning amino acids (a. a.) 255-620 is required for efficient inhibition of DNA replication, and that, within this region, a. a. 255-289 have a critical role in inhibition. PMID: 28694193
    2. conserved arginine residues play critical roles in interaction with Geminin and Mcm that are crucial for proper conformation of the complexes and its licensing activity. PMID: 26940553
    3. These findings suggested that excess Cdt1 suppressed the progression of replication forks. PMID: 26773501
    4. Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos. PMID: 22096080
    5. Loading of geminin onto chromatin requires Cdt1, suggesting that geminin is targeted at replication origins. PMID: 15051497
    6. results allow us to build a comprehensive model of how re-replication of DNA is prevented in Xenopus, with Cdt1 regulation being the key feature PMID: 15616577
    7. Removal of Cdt1 from chromatin and its nuclear exclusion in G2 is critical in regulating licensing and limiting DNA replication in S phase to only one round. PMID: 15668171
    8. Cdt1 and DDB1 interact in extracts, and DDB1 chromatin loading is dependent on the binding of Cdt1 to PCNA, which indicates that PCNA docking activates the pre-formed Cdt1-Cul4(DDB1) ligase complex. PMID: 16362051
    9. These results suggest a model in which the MCM2-7 helicase is loaded onto chromatin by a Cdt1-geminin complex, which is inactivated upon origin firing by binding additional geminin. PMID: 17124498
    10. Cdt1, with its two opposing regulatory binding factors MCM9 and geminin, appears to be a major platform on the pre-replication complexes to integrate cell-cycle signals. PMID: 18657502
    11. Cdt1 blocks nascent chain elongation after detecting illegitimate activation of the licensing system. PMID: 19064889
    12. during meiosis Geminin functions as a stabilizer of Cdt1 promoting its accumulation for the early division cycles of the embryo PMID: 19656945

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Cdt1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: xla:398024

    UniGene: Xl.273



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