在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Simian immunodeficiency virus Protein Tat (tat)

  • 中文名稱(chēng):
    Recombinant Simian immunodeficiency virus Protein Tat(tat)
  • 貨號(hào):
    CSB-YP324616SGW
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱(chēng):
    Recombinant Simian immunodeficiency virus Protein Tat(tat)
  • 貨號(hào):
    CSB-EP324616SGW
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱(chēng):
    Recombinant Simian immunodeficiency virus Protein Tat(tat)
  • 貨號(hào):
    CSB-EP324616SGW-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱(chēng):
    Recombinant Simian immunodeficiency virus Protein Tat(tat)
  • 貨號(hào):
    CSB-BP324616SGW
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱(chēng):
    Recombinant Simian immunodeficiency virus Protein Tat(tat)
  • 貨號(hào):
    CSB-MP324616SGW
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    tat
  • Uniprot No.:
  • 別名:
    tat; Protein Tat; Transactivating regulatory protein
  • 種屬:
    Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-100
  • 氨基酸序列
    MDPIDPDLEP WKHPGSQPRT VCNNCYCKAC CYHCIYCFTK KGLGISYGRK KRTTRRRTAP AGSKNNQDSI PKQPLSQSRG NKEGSEKSTK EVASKTEADQ
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. In the absence of Tat, the RNA Pol II generates short or non-processive transcripts that terminate at approximately 60 bp from the initiation site. Tat associates with the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. This binding increases Tat's affinity for a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively to TAR RNA. The CDK9 component of P-TEFb and other Tat-activated kinases hyperphosphorylate the C-terminus of RNA Pol II that becomes stabilized and much more processive. Other factors such as HTATSF1/Tat-SF1, SUPT5H/SPT5, and HTATIP2 are also important for Tat's function. Besides its effect on RNA Pol II processivity, Tat induces chromatin remodeling of proviral genes by recruiting the histone acetyltransferases (HATs) CREBBP, EP300 and PCAF to the chromatin. This also contributes to the increase in proviral transcription rate, especially when the provirus integrates in transcriptionally silent region of the host genome. To ensure maximal activation of the LTR, Tat mediates nuclear translocation of NF-kappa-B by interacting with host RELA. Through its interaction with host TBP, Tat may also modulate transcription initiation. Tat can reactivate a latently infected cell by penetrating in it and transactivating its LTR promoter. In the cytoplasm, Tat is thought to act as a translational activator of HIV-1 mRNAs.; Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR. Neurons are rarely infected, but they internalize Tat via their LDLR. Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression. Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors. Tat plays a role in T-cell and neurons apoptosis. Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS. Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways. In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
  • 亞細(xì)胞定位:
    Host nucleus, host nucleolus. Host cytoplasm. Secreted.
  • 蛋白家族:
    Lentiviruses Tat family


主站蜘蛛池模板: 亚洲熟女乱色一区二区三区| 人人揉揉揉香蕉大免费| 国产成人无码精品久久久免费| 亚洲国产成人精品青青草原| 亚洲精品无码高潮喷水a片软| 夜夜欢性恔真人免费视频| 日韩欧美mv在线观看免费| 色中色成人导航| 国产激情久久久久久熟女老人av| 丰满岳乱妇在线观看中字无码| 好男人社区神马在线观看www| 日韩去日本高清在线| 欧美极品色午夜在线视频 | 新国产三级视频在线播放| 国产精品vr专区| 亚洲国产成在人网站天堂| 国内少妇偷人精品视频| 日本免费一区二区三区视频观看| 女人大荫蒂毛茸茸视频| 又色又爽又高潮免费观看| 午夜亚洲影院在线观看| 午夜福利无码不卡在线观看| 无码精品视频一区二区三区| 天堂在线资源中文在线8| 韩国国内大量揄拍精品视频| 欧洲精品成人免费视频在线观看| 99久久精品费精品国产一区二区| 无码毛片视频一区二区本码| 国产精品福利自产拍在线观看| 妖精色av无码国产在线看| 777yyy亚洲精品久久久| 午夜一区一品日本| 久久久综合亚洲色一区二区三区| 久久精品国产精品亚洲下载| 99久久无色码中文字幕人妻| 国产在线精品99一区不卡| 免费精品国产人妻国语| 色欲αv一区二区三区天美传媒| 男女猛烈无遮挡免费视频app | 国产天美传媒性色av出轨| 国产亚洲精品欧洲在线观看 |