在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Simian immunodeficiency virus Protein Nef (nef)

  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-YP623327SBAM
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-EP623327SBAM
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-EP623327SBAM-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-BP623327SBAM
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-MP623327SBAM
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    nef
  • Uniprot No.:
  • 別名:
    nef; Protein Nef; 3'ORF; Negative factor; F-protein) [Cleaved into: C-terminal core protein]
  • 種屬:
    Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-206
  • 氨基酸序列
    GKVWSKSSL VGWPQVIDRM RRQQDPAEGV GAVSQDLANR GAITIRNTKE NNQALAWLEE QKEEAVGFPV CPQVPLRPMT YKEAFDLSFF LREKGGLEGL VWSTKRQEIL DLWVYHTQGI FPDWQNYTPG PGVRYPLTFG WCFKLVPLSP EEVEEANQGD NNVLLHPMCQ HGMEDPDKEV LVWRFDSSLA RVHRARELHP EFYQNC
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocytes function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells.; In infected CD4(+) T-lymphocytes, down-regulates the surface MHC-I, mature MHC-II, CD4, CD28, CCR5 and CXCR4 molecules. Mediates internalization and degradation of host CD4 through the interaction of with the cytoplasmic tail of CD4, the recruitment of AP-2 (clathrin adapter protein complex 2), internalization through clathrin coated pits, and subsequent transport to endosomes and lysosomes for degradation. Diverts host MHC-I molecules to the trans-Golgi network-associated endosomal compartments by an endocytic pathway to finally target them for degradation. MHC-I down-regulation may involve AP-1 (clathrin adapter protein complex 1) or possibly Src family kinase-ZAP70/Syk-PI3K cascade recruited by PACS2. In consequence infected cells are masked for immune recognition by cytotoxic T-lymphocytes. Decreasing the number of immune receptors also prevents reinfection by more HIV particles (superinfection). Down-regulates host SERINC3 and SERINC5 thereby excluding these proteins from the viral particles. Virion infectivity is drastically higher when SERINC3 or SERINC5 are excluded from the viral envelope, because these host antiviral proteins impare the membrane fusion event necessary for subsequent virion penetration.; Bypasses host T-cell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. Interaction with TCR-zeta chain up-regulates the Fas ligand (FasL). Increasing surface FasL molecules and decreasing surface MHC-I molecules on infected CD4(+) cells send attacking cytotoxic CD8+ T-lymphocytes into apoptosis.; Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5/ASK1. Decreases the half-life of TP53, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that leads to activation of PAK2 and induces phosphorylation of host BAD.; Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
  • 亞細胞定位:
    Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane.
  • 蛋白家族:
    Lentivirus primate group Nef protein family


主站蜘蛛池模板: 国产av亚洲aⅴ一区二区| 欧美z0zo人禽交免费观看99| 国产精品毛片av999999| 久久久久久好爽爽久久| 国产草草影院ccyycom| 中文字幕乱码人妻综合二区三区| 国产成人人人97超碰超爽8| 特级a做爰全过程片| 国产偷窥熟精品视频| 亚洲全部无码中文字幕| 国产精品涩涩涩视频网站| 色噜噜狠狠色综合日日| 亚洲精品国产av天美传媒| 国产美女爽到喷出水来视频 | 国产欧美精品一区二区三区四区| 丰满人妻妇伦又伦精品国产| 日本三级理论久久人妻电影| 亚洲一区无码中文字幕| 久久无码精品一一区二区三区| 中文字幕无码精品亚洲资源网久久| 欧美成人午夜精品久久久| 国产精品亚洲专区无码web| 欧美日韩不卡高清在线看| 国产日韩综合av在线观看一区 | 蜜桃视频无码区在线观看| 久久久www成人免费毛片| 18禁黄网站禁片免费观看不卡| 久九九久视频精品免费| 国产日产久久高清欧美一区| 国产精品无码久久久久成人影院| 黄网站色视频免费国产| 中国凸偷窥xxxx自由视频| 亚洲精品中文字幕| 激情综合色综合啪啪五月丁香| 国产成人av综合久久| 午夜伦4480yy私人影院久久| 最近最新中文字幕高清免费| 黑人粗硬进入过程视频| 亚洲人成无码www久久久| 国产午精品午夜福利757视频播放| 无码av永久免费专区麻豆|