在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Simian immunodeficiency virus Protein Nef (nef)

  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-YP618332SBAL
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-EP618332SBAL
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-EP618332SBAL-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-BP618332SBAL
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Simian immunodeficiency virus Protein Nef(nef)
  • 貨號:
    CSB-MP618332SBAL
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    nef
  • Uniprot No.:
  • 別名:
    nef; Protein Nef; 3'ORF; Negative factor; F-protein) [Cleaved into: C-terminal core protein]
  • 種屬:
    Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-206
  • 氨基酸序列
    GGKWSKSSL VGWPEVRDRL RRTQTAAEGV GPVSRDLARH GAITSRNTSQ TNETLAWLEE VQNEEVGFPV RPQVPLRPMT FKGAFDLSHF LKEKGGLEGL VYSKKRQEIL DLWVYHTQGF FPDWQNYTPG PGIRYPLTFG WCFKLVPLEP EEVERANEGD NNILLHPICQ HGQEDEAREV LVWTFDSRLA LKHRARELHP EYYKDC
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocytes function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells.; In infected CD4(+) T-lymphocytes, down-regulates the surface MHC-I, mature MHC-II, CD4, CD28, CCR5 and CXCR4 molecules. Mediates internalization and degradation of host CD4 through the interaction of with the cytoplasmic tail of CD4, the recruitment of AP-2 (clathrin adapter protein complex 2), internalization through clathrin coated pits, and subsequent transport to endosomes and lysosomes for degradation. Diverts host MHC-I molecules to the trans-Golgi network-associated endosomal compartments by an endocytic pathway to finally target them for degradation. MHC-I down-regulation may involve AP-1 (clathrin adapter protein complex 1) or possibly Src family kinase-ZAP70/Syk-PI3K cascade recruited by PACS2. In consequence infected cells are masked for immune recognition by cytotoxic T-lymphocytes. Decreasing the number of immune receptors also prevents reinfection by more HIV particles (superinfection). Down-regulates host SERINC3 and SERINC5 thereby excluding these proteins from the viral particles. Virion infectivity is drastically higher when SERINC3 or SERINC5 are excluded from the viral envelope, because these host antiviral proteins impare the membrane fusion event necessary for subsequent virion penetration.; Bypasses host T-cell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. Interaction with TCR-zeta chain up-regulates the Fas ligand (FasL). Increasing surface FasL molecules and decreasing surface MHC-I molecules on infected CD4(+) cells send attacking cytotoxic CD8+ T-lymphocytes into apoptosis.; Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5/ASK1. Decreases the half-life of TP53, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that leads to activation of PAK2 and induces phosphorylation of host BAD.; Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
  • 亞細胞定位:
    Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane.
  • 蛋白家族:
    Lentivirus primate group Nef protein family


主站蜘蛛池模板: 国产精品美女久久久久网站浪潮| 国产99视频精品免视看7| 午夜一区一品日本| 国产suv精品一区二区| 久久久午夜精品福利内容| 无码中文字幕日韩专区| 无码午夜成人1000部免费视频| 成人国产片视频在线观看| 日韩一区二区三区北条麻妃| 亚洲午夜无码久久yy6080| 亚洲sm另类一区二区三区| 无码加勒比一区二区三区四区 | www亚洲精品少妇裸乳一区二区| 娇妻玩4p被三个男人伺候电影| 一本大道久久东京热无码av| 好了av在线第四综合网站| 成人做爰视频www网站| 四虎影视永久免费观看在线| 久久久久久久久蜜桃| 亚洲精品永久在线观看| 蜜臀av色欲a片无码精品一区| 精品亚洲国产成人av在线时间短的| 人妻熟女一区二区aⅴ水野朝阳| 亚洲人亚洲人成电影网站色| 欧美老人巨大xxxx做受| 午夜无码乱码在线观看| 国产精品美脚玉足脚交| 国产精品va无码二区| 亚洲中文字幕无码久久| 免费国产黄网站在线观看动图| 亚洲综合精品伊人久久| 欧美精品videossex另类日本| 青青热久免费精品视频| 奇米影视7777久久精品| 欧美丰满熟妇hdxx| 免费精品国偷自产在线在线| 成人性无码专区免费视频| 欧美顶级少妇做爰hd| 久久亚洲a片com人成| 久久精品66免费99精品| 亚洲男男无套gv大学生|