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  4. Recombinant Sheep Follitropin subunit beta (FSHB)

Recombinant Sheep Follitropin subunit beta (FSHB)

  • 中文名稱：
    綿羊FSHB重組蛋白
  • 貨號：
    CSB-YP009018SH
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    綿羊FSHB重組蛋白
  • 貨號：
    CSB-EP009018SH
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    綿羊FSHB重組蛋白
  • 貨號：
    CSB-EP009018SH-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    綿羊FSHB重組蛋白
  • 貨號：
    CSB-BP009018SH
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    綿羊FSHB重組蛋白
  • 貨號：
    CSB-MP009018SH
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    FSHBFollitropin subunit beta; Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain
  • 種屬：
    Ovis aries (Sheep)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    20-129
  • 氨基酸序列
    S CELTNITITV EKEECSFCIS INTTWCAGYC YTRDLVYKDP ARPNIQKACT FKELVYETVK VPGCAHHADS LYTYPVATEC HCGKCDRDST DCTVRGLGPS YCSFSDIRE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
  • 基因功能參考文獻：
    1. A novel GnRH response element between -750 bp and -232 bp of the ovine FSHB promoter. PMID: 23874399
    2. Data suggest that dietary components (phytoestrogens here) down-regulate basal secretion/total FSH (CGA+FSHB) production yet up-regulate gonadotropin-releasing hormone agonist-induced luteinizing hormone (CGA+LHB) secretion in gonadotrophs. PMID: 24050980
    3. In ewes, infusion with genistein decreased the level FSH-beta in the adenohypophysis. PMID: 15531133
    4. Activation of TAK1 (and probably p38-MAPK), but not Smad3, is necessary for triggering induction of oFSHbeta by activin. PMID: 16081641
    5. Activin gathers Smads and Smad-associated proteins at the promoter region to regulate expression of the ovine FSHB and overall follitropin production. PMID: 17584958

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Glycoprotein hormones subunit beta family
  • 數據庫鏈接：

    KEGG: oas:443387

    UniGene: Oar.430



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