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  4. Recombinant Serine/threonine-protein kinase sgk-1 (sgk-1)

Recombinant Serine/threonine-protein kinase sgk-1 (sgk-1)

  • 中文名稱：
    秀麗隱桿線蟲sgk-1重組蛋白
  • 貨號：
    CSB-YP650826CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲sgk-1重組蛋白
  • 貨號：
    CSB-EP650826CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲sgk-1重組蛋白
  • 貨號：
    CSB-EP650826CXY-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲sgk-1重組蛋白
  • 貨號：
    CSB-BP650826CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲sgk-1重組蛋白
  • 貨號：
    CSB-MP650826CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    sgk-1
  • Uniprot No.：
  • 別名：
    sgk-1; W10G6.2; Serine/threonine-protein kinase sgk-1; EC 2.7.11.1; Serum- and glucocorticoid-inducible kinase homolog; Serum/glucocorticoid-regulated kinase 1
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-463
  • 氨基酸序列
    MGSMYYNESR MVRKDEVTCN VIIGDDKKTV VYALRIGNGP IMQKTFEEYE RFFTTEKDMI PATIFTAPKK KFLQADSKFY EKRRVWILVI SQHLVDNNLR SEDVRRFFHL ESPDDDENNV DLGPSERKTA TANDFDYLTT IGKGSFGRVY QVRHKETKKI YAMKILSKEH IRKKNEVKHV MAERNVLINN FKHPFLVSLH FSFQNKEKLY FVLDHLNGGE LFSHLQREKH FSESRSRFYA AEIACALGYL HEKNIIYRDL KPENLLLDDK GYLVLTDFGL CKEDMQGSKT TSTFCGTPEY LAPEIILKKP YDKTVDWWCL GSVLYEMIFG LPPFYSKDHN EMYDKIINQP LRLKHNISVP CSELITGLLQ KDRSKRLGHR NDFRDIRDHP FFLPVDWDKL LNRELKAPFI PKVKNAMDTS NISKEFVEIQ IDPSSLAPQQ LAVTHRDHDF ENFTFVDTNR VLV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Promotes the cytoplasmic localization of the transcription factor pqm-1. Plays a role in the intracellular trafficking of proteins such as mig-14 to the cell membrane, and this may be through positively regulating ceramide synthesis. Acts downstream of rict-1 to regulate fat storage, size, development and vitellogenesis. Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development. Does not appear to play a role in immune function.
  • 基因功能參考文獻：
    1. SGK-1 acts in parallel to the AKT kinases to mediate DAF-2 signaling. Loss of sgk-1 results in defective egg-laying, extended generation time, increased stress resistance, and an extension of life span. PMID: 15068796
    2. findings indicate that SGK-1 is a mediator of Rictor activity; findings identify new physiological roles for TORC2, mediated by SGK, in regulation of C. elegans lipid accumulation and growth PMID: 19260765
  • 亞細胞定位：
    Cytoplasm. Nucleus. Apical cell membrane.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family
  • 組織特異性：
    Expressed in late embryos just before hatching. At postembryonic stages, expressed in sensory and motor neurons and in the intestine. Highly expressed in the intestine and head and tail neurons.
  • 數(shù)據(jù)庫鏈接：

    KEGG: cel:CELE_W10G6.2

    STRING: 6239.W10G6.2b

    UniGene: Cel.19781



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