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  4. Recombinant Schizosaccharomyces pombe Tyrosine-protein phosphatase CDC14 homolog (clp1), partial

Recombinant Schizosaccharomyces pombe Tyrosine-protein phosphatase CDC14 homolog (clp1), partial

  • 中文名稱：
    Recombinant Schizosaccharomyces pombe Tyrosine-protein phosphatase CDC14 homolog(clp1) ,partial
  • 貨號：
    CSB-YP879122SXV
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Schizosaccharomyces pombe Tyrosine-protein phosphatase CDC14 homolog(clp1) ,partial
  • 貨號：
    CSB-EP879122SXV
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Schizosaccharomyces pombe Tyrosine-protein phosphatase CDC14 homolog(clp1) ,partial
  • 貨號：
    CSB-EP879122SXV-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Schizosaccharomyces pombe Tyrosine-protein phosphatase CDC14 homolog(clp1) ,partial
  • 貨號：
    CSB-BP879122SXV
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Schizosaccharomyces pombe Tyrosine-protein phosphatase CDC14 homolog(clp1) ,partial
  • 貨號：
    CSB-MP879122SXV
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    clp1
  • Uniprot No.：
  • 別名：
    clp1; flp1; SPAC1782.09c; Tyrosine-protein phosphatase CDC14 homolog; EC 3.1.3.48; CDC fourteen-like phosphatase 1
  • 種屬：
    Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Protein phosphatase which antagonizes mitotic cyclin-dependent kinase cdc2, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases. Allows damaged actomyosin rings to be maintained to facilitate completion of cell division in response to minor perturbation of the cell division machinery. Dephosphorylates the mitotic inducer cdc25 for its rapid degradation. Down-regulation of cdc25 activity ensures a prompt inactivation of mitotic cdc2 complexes to trigger cell division. Dephosphorylates also cdc2-phosphorylated nsk1, allowing nsk1-binding to kinetochores and spindle. Dephosphorylates ase1, which is essential for spindle midzone assembly and for continuous extension of the anaphase spindle. Tethered to the contractile ring by mid1, where it dephosphorylates cdc15.
  • 基因功能參考文獻：
    1. Sal3, a nuclear beta-importin, is the sole karyopherin required for Clp1 nucleoplasmic shuttling. PMID: 23297348
    2. Relocalization of Clp1 during genotoxic stress is governed by complex phosphoregulation. PMID: 22918952
    3. Clp1p is required to dephosphorylate, destabilize, and inactivate Cdc25p at the end of mitosis PMID: 14765109
    4. Clp1p/Flp1p-dependent cytokinesis checkpoint provides a previously unrecognized cell survival advantage when the cell division apparatus is mildly perturbed PMID: 15265986
    5. hCdc14A and hCdc14B have functional homology to S. pombe Cdc25 and flp1 PMID: 15911625
    6. Clp1 plays distinct roles in chromosome segreagation when localized in the nucleus, and cytokinesis, in the nucleolus. PMID: 16085490
    7. These findings point to a simple regulatory circuit that couples Cdk1 activation with its inactivation mediated through phosphorylation-dependent regulation of Clp1/Flp1 phosphatase activity. PMID: 16950131
    8. Thus Flp1p appears to have an important role in integrating HECT- and RING-type ubiquitin ligases in cell cycle control. PMID: 18418059
    9. Clp1 is maintained in the cytoplasm by Sid2. Loss of Clp1 from the cytoplasm in telophase renders cells sensitive to perturbation of the actomyosin ring but does not affect other Clp1 functions. PMID: 18951025

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  • 亞細胞定位：
    Nucleus, nucleolus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cell septum. Note=Localizes to kinetochores in prometaphase. Cytoplasmic retention is mediated through the binding of rad24. Tethered to the contractile ring by mid1.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily
  • 數據庫鏈接：


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