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  4. Recombinant Saccharomyces cerevisiae Serine/threonine-protein kinase/endoribonuclease IRE1 (IRE1), partial

Recombinant Saccharomyces cerevisiae Serine/threonine-protein kinase/endoribonuclease IRE1 (IRE1), partial

  • 中文名稱：
    釀酒酵母IRE1重組蛋白
  • 貨號：
    CSB-YP007795SVG
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母IRE1重組蛋白
  • 貨號：
    CSB-EP007795SVG
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母IRE1重組蛋白
  • 貨號：
    CSB-EP007795SVG-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母IRE1重組蛋白
  • 貨號：
    CSB-BP007795SVG
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母IRE1重組蛋白
  • 貨號：
    CSB-MP007795SVG
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    IRE1
  • Uniprot No.：
  • 別名：
    IRE1; ERN1; YHR079C; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase; EC 2.7.11.1); Endoribonuclease; EC 3.1.26.-)]
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.
  • 基因功能參考文獻：
    1. The most conserved transducer of ER stress, Ire1, uses an amphipathic helix to sense membrane aberrancies and control unfolded protein response activity. PMID: 28689662
    2. Here we show that in yeast cells, the ER-stress sensor Ire1 was activated upon zinc deficiency PMID: 23748779
    3. Under ER stress, Ire1 molecules exist in activated and Bip-associated state. PMID: 23387983
    4. Results show that the kinase domain autophosphorylatse the auto-inhibitory region in order to relieve auto-inhibition and that ADP acts as a switch to activate the kinase extension nuclease domain-catalyzed HAC1 mRNA cleavage. PMID: 23541589
    5. the cytosolic or transmembrane domain of Ire1 senses membrane aberrancy PMID: 21775630
    6. core ER-lumenal domain (cLD) of Ire1 binds to unfolded proteins in yeast and to peptides in vitro; peptide binding caused Ire1 cLD oligomerization in vitro, suggesting direct binding to unfolded proteins activates unfolded protein response PMID: 21852455
    7. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. PMID: 20417606
    8. although its sequence is little conserved evolutionarily, subregion IV plays an essential role to promote Ire1 dimer formation PMID: 15954865
    9. Our results are consistent with de-phosphorylation of Ire1 being a mechanism for antagonizing UPR signalling. PMID: 16990850
    10. The capacity of a highly basic sequence in the linker region of Ire1p to function as a nuclear localization sequence (NLS) both in vivo and in vitro, was analyzed. PMID: 17035634
    11. Observations indicate that in addition to BiP dissociation and self-association of Ire1, another unknown change on the luminal side is crucial for Ire1 activation. PMID: 17452628
    12. Upon endoplasmic reticulum (ER) stress, Ire1 clusters and actually interacts with unfolded proteins. PMID: 17923530
    13. We have determined the crystal structure of the dual catalytic region of Ire1at 2.4 A resolution, revealing the fusion of a domain, which we term the KEN domain, to the protein kinase domain. PMID: 18191223
    14. oligomerization is central to Ire1 function and is an intrinsic attribute of its cytosolic domains; 3.2-A crystal structure of the oligomer of the Ire1 cytosolic domains in complex with a kinase inhibitor PMID: 19079236

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 數據庫鏈接：

    KEGG: sce:YHR079C

    STRING: 4932.YHR079C



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