在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Saccharomyces cerevisiae Postreplication repair E3 ubiquitin-protein ligase RAD18 (RAD18)

Recombinant Saccharomyces cerevisiae Postreplication repair E3 ubiquitin-protein ligase RAD18 (RAD18)

  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-YP319938SVG
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-EP319938SVG
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-EP319938SVG-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-BP319938SVG
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-MP319938SVG
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RAD18
  • Uniprot No.：
  • 別名：
    RAD18; YCR066W; YCR66W; Postreplication repair E3 ubiquitin-protein ligase RAD18; EC 2.3.2.27; RING-type E3 ubiquitin transferase RAD18; Radiation sensitivity protein 18
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-487
  • 氨基酸序列
    MDHQITTASD FTTTSIPSLY QLDTLLRCHI CKDFLKVPVL TPCGHTFCSL CIRTHLNNQP NCPLCLFEFR ESLLRSEFLV SEIIQSYTSL RSSLLDALRI PKPTPVPENE EVPGPENSSW IELISESESD SVNAADDDLQ IVATSERKLA KRSMTDILPL SSKPSKRNFA MFRSERIKKK SKPNEQMAQC PICQQFYPLK ALEKTHLDEC LTLQSLGKKP KISTTFPTES NPHNKSSSRF KVRTPEVDKS SCGETSHVDK YLNSMMSAEH QRLPKINFTS MTQSQIKQKL SSLGLSTNGT RQNMIKRYNH YEMLWNSNFC DSLEPVDEAE LKRQLLSWDV SHNKTPQNSS NKGGISKLMI MKSNGKSSSY RKLLENFKND KFNRKGWMVM FRKDFARLIR EAKMKIKTGS SDSSGSVGHS NDGDGVEKVQ SDQGTEDQQM EKDQDTVINE DRVAGERNLP NEDSTDADLS RELMDLNEYS KDPPGNN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR. The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.
  • 基因功能參考文獻：
    1. The Pol30-K196 residue plays a critical role in budding yeast DNA post-replication repair through interaction with Rad18. PMID: 27707542
    2. following UV-induced damage, reactivation of Rad18, even after prolonged G2 arrest, restores viability and genome integrity. PMID: 23382077
    3. The results imply that sumoylated PCNA is the physiological ubiquitylation target of budding yeast Rad18. PMID: 23034805
    4. In this study we showed that DNA damage induced by hydrogen peroxide at the same mutagen doses causes significantly more mutations and lethal events in the rad18 mutant cells compared to control wild-type cells PMID: 22730775
    5. Rad17, a subunit of the PCNA-like 9-1-1 checkpoint clamp is ubiquitylated; however, in contrast to previous results, modification of Rad17 is found to be independent of DNA damage, the Rad6-Rad18 complex. PMID: 20550940
    6. Rad6-Rad18 and Ubc13-Mms2-Rad5 act sequentially and mediate proliferating cell nuclear antigen poly-ubiquitylation by stepwise addition of ubiquitin monomers. PMID: 19851286
    7. role in polyubiquitination of PCNA PMID: 15507115
    8. error-free component of the RAD6/RAD18 pathway completes replication by a mechanism employing recombination between partially replicated sister strands, possibly by means of transient template strand switching or copy choice. PMID: 16247017
    9. Study suggests that Rad18/Rad5/Mms2 and Mgs1 are required to promote replication when forks are destabilized or stalled due to defects in Pol delta. PMID: 16949354
    10. Rad6-Rad18 promotes DNA-damage-dependent transcriptional induction as well as checkpoint functions by catalyzing monoubiquitination at the K197 residue of the Rad17 subunit of the 9-1-1 complex. PMID: 18485869
    11. The interactions between Rad18, RPA and DNA and discuss their contribution to the activation of DNA damage bypass, was examined. PMID: 19029798
    12. key role for the RAD6-RAD18-RAD5 error-free postreplication repair (RAD6 error-free PRR) pathway in promoting cell growth and survival, in response to chronic low-dose ultraviolet light PMID: 19079240
    13. Rad18 is required for the formation of X-shaped sister chromatid junctions (SCJs) at damaged replication forks through a process involving PCNA polyubiquitylation and the ubiquitin-conjugating enzymes Mms2 and Ubc13 PMID: 19092928

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    RAD18 family
  • 數據庫鏈接：

    KEGG: sce:YCR066W

    STRING: 4932.YCR066W



主站蜘蛛池模板： 中文字幕一区二区三区精华液 | 无码国模国产在线观看| 亚洲 丝袜 另类 校园 欧美| 欧美牲交a欧牲交aⅴ久久| 亚洲狠狠婷婷综合久久蜜芽| 成全世界免费高清观看| 天堂mv在线mv免费mv香蕉| 无码少妇精品一区二区免费动态| 8ⅹ8x擦拨擦拨成人免费视频 | 国产精品一区二区av蜜芽| 天堂在线最新版www中文| 中文字幕人妻丝袜成熟乱 | 丰满的人妻hd高清日本| 国产黄在线观看免费观看不卡| 日本wv一本一道久久香蕉| 最新国产麻豆aⅴ精品无码| 色婷婷综合缴情综免费观看| 天堂在线观看www| 国内揄拍国产精品人妻门事件| 一本色道久久综合亚州精品蜜桃| 99精品全国免费观看视频| 夜夜欢天天干| 日韩av激情在线观看| 国产乱子伦农村叉叉叉| 人人做人人爽久久久精品| 欧美成年网站色a| 亚洲色成人中文字幕网站 | 午夜国产成人片在线播放| 国产又爽又大又黄a片| 无码高潮爽到爆的喷水视频| 中文字幕精品无码一区二区三区| a毛看片免费观看视频| 午夜亚洲影院在线观看| 三级特黄60分钟在线播放| 国产精品久久久久久久久久久不卡 | 日日摸天天摸人人看| 在线视+欧美+亚洲日本| 色欧美片视频在线观看| 红桃av一区二区三区在线无码av| 天天爽夜夜爽人人爽从早干到睌| 国产尤物在线视精品在亚洲|