在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Saccharomyces cerevisiae Postreplication repair E3 ubiquitin-protein ligase RAD18 (RAD18)

Recombinant Saccharomyces cerevisiae Postreplication repair E3 ubiquitin-protein ligase RAD18 (RAD18)

  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-YP319938SVG
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-EP319938SVG
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-EP319938SVG-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-BP319938SVG
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母RAD18重組蛋白
  • 貨號：
    CSB-MP319938SVG
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RAD18
  • Uniprot No.：
  • 別名：
    RAD18; YCR066W; YCR66W; Postreplication repair E3 ubiquitin-protein ligase RAD18; EC 2.3.2.27; RING-type E3 ubiquitin transferase RAD18; Radiation sensitivity protein 18
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-487
  • 氨基酸序列
    MDHQITTASD FTTTSIPSLY QLDTLLRCHI CKDFLKVPVL TPCGHTFCSL CIRTHLNNQP NCPLCLFEFR ESLLRSEFLV SEIIQSYTSL RSSLLDALRI PKPTPVPENE EVPGPENSSW IELISESESD SVNAADDDLQ IVATSERKLA KRSMTDILPL SSKPSKRNFA MFRSERIKKK SKPNEQMAQC PICQQFYPLK ALEKTHLDEC LTLQSLGKKP KISTTFPTES NPHNKSSSRF KVRTPEVDKS SCGETSHVDK YLNSMMSAEH QRLPKINFTS MTQSQIKQKL SSLGLSTNGT RQNMIKRYNH YEMLWNSNFC DSLEPVDEAE LKRQLLSWDV SHNKTPQNSS NKGGISKLMI MKSNGKSSSY RKLLENFKND KFNRKGWMVM FRKDFARLIR EAKMKIKTGS SDSSGSVGHS NDGDGVEKVQ SDQGTEDQQM EKDQDTVINE DRVAGERNLP NEDSTDADLS RELMDLNEYS KDPPGNN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR. The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.
  • 基因功能參考文獻：
    1. The Pol30-K196 residue plays a critical role in budding yeast DNA post-replication repair through interaction with Rad18. PMID: 27707542
    2. following UV-induced damage, reactivation of Rad18, even after prolonged G2 arrest, restores viability and genome integrity. PMID: 23382077
    3. The results imply that sumoylated PCNA is the physiological ubiquitylation target of budding yeast Rad18. PMID: 23034805
    4. In this study we showed that DNA damage induced by hydrogen peroxide at the same mutagen doses causes significantly more mutations and lethal events in the rad18 mutant cells compared to control wild-type cells PMID: 22730775
    5. Rad17, a subunit of the PCNA-like 9-1-1 checkpoint clamp is ubiquitylated; however, in contrast to previous results, modification of Rad17 is found to be independent of DNA damage, the Rad6-Rad18 complex. PMID: 20550940
    6. Rad6-Rad18 and Ubc13-Mms2-Rad5 act sequentially and mediate proliferating cell nuclear antigen poly-ubiquitylation by stepwise addition of ubiquitin monomers. PMID: 19851286
    7. role in polyubiquitination of PCNA PMID: 15507115
    8. error-free component of the RAD6/RAD18 pathway completes replication by a mechanism employing recombination between partially replicated sister strands, possibly by means of transient template strand switching or copy choice. PMID: 16247017
    9. Study suggests that Rad18/Rad5/Mms2 and Mgs1 are required to promote replication when forks are destabilized or stalled due to defects in Pol delta. PMID: 16949354
    10. Rad6-Rad18 promotes DNA-damage-dependent transcriptional induction as well as checkpoint functions by catalyzing monoubiquitination at the K197 residue of the Rad17 subunit of the 9-1-1 complex. PMID: 18485869
    11. The interactions between Rad18, RPA and DNA and discuss their contribution to the activation of DNA damage bypass, was examined. PMID: 19029798
    12. key role for the RAD6-RAD18-RAD5 error-free postreplication repair (RAD6 error-free PRR) pathway in promoting cell growth and survival, in response to chronic low-dose ultraviolet light PMID: 19079240
    13. Rad18 is required for the formation of X-shaped sister chromatid junctions (SCJs) at damaged replication forks through a process involving PCNA polyubiquitylation and the ubiquitin-conjugating enzymes Mms2 and Ubc13 PMID: 19092928

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    RAD18 family
  • 數據庫鏈接：

    KEGG: sce:YCR066W

    STRING: 4932.YCR066W



主站蜘蛛池模板： 日韩aⅴ人妻无码一区二区| 天天躁日日躁狠狠躁一区| 亚洲第一成人网站| 色偷偷噜噜噜亚洲男人| 免费无码久久成人影片| 69久久国产露脸精品国产| 天堂在/线中文在线资源8| 日本无遮挡吸乳呻吟视频| 人人妻人人澡av天堂香蕉| 污污污污污污www网站免费| 色综合久久久久综合体桃花网| 亚洲va在线va天堂xxxx中文 | 久久精品国产99久久久古代| 久久精品国产久精国产一老狼 | 在线|国产精品女主播阳台| 99久久国产综合精品五月天喷水 | 精品福利一区二区三区免费视频| 色情无码一区二区三区| 中文字幕无码人妻丝袜| 人妻丰满av无码中文字幕| 永久免费无码网站在线观看| 亚洲人精品午夜射精日韩 | 韩国乱码片免费看| 特级a欧美做爰片第一次| 国产精品毛片大码女人| 欧美性videos高清精品| 在线精品动漫一区二区无码| 国产无遮挡又爽又黄的视频| 久久久久免费看黄a片app| 午夜精品久久久久久久99热| 色伊人亚洲综合网站| 超级大爆乳奶牛被调教出奶水| 日韩亚洲欧美中文高清在线| 动漫av网站免费观看| 特黄特级毛片免费视频| 无码三级国产三级在线电影| 日本xxxx裸体xxxx视频大全| 国产真人无遮挡作爱免费视频| 女女同性av片在线观看免费| 欧美成人午夜性视频| 午夜亚洲福利在线老司机|