Recombinant Saccharomyces cerevisiae Hsp90 co-chaperone HCH1 (HCH1)

中文名稱：

釀酒酵母HCH1重組蛋白
貨號：

CSB-YP345708SVG
規格：
來源：

Yeast
其他：

中文名稱：

釀酒酵母HCH1重組蛋白
貨號：

CSB-EP345708SVG
規格：
來源：

E.coli
其他：

中文名稱：

釀酒酵母HCH1重組蛋白
貨號：

CSB-EP345708SVG-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

釀酒酵母HCH1重組蛋白
貨號：

CSB-BP345708SVG
規格：
來源：

Baculovirus
其他：

中文名稱：

釀酒酵母HCH1重組蛋白
貨號：

CSB-MP345708SVG
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HCH1
Uniprot No.：

P53834
別名：

HCH1; YNL281W; N0589; Hsp90 co-chaperone HCH1; High-copy Hsp90 suppressor protein 1
種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
蛋白長度：

full length protein
表達區域：

1-153
氨基酸序列

MVVLNPNNWH WVDKNTLPWS KDYLNGKLTS LSTVSSDGKS KIELTQVSSI TGDSNVSQRK GKPICYFDLQ LSMNVKVTNL DTNKDDEDDD GILADGKLEI PEFMHDESDI PILSQGFDAF DGLVRSEFVP KVVETLLKYQ DDLIKEHSKD IQV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity. Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting.
基因功能參考文獻：
1. Phosphorylation of human Hsp90alpha at the highly conserved tyrosine (Y) 627 affects it conformation and function. Y627 is not phosphorylated in yeast, but study demonstrated that the non-conserved yeast co-chaperone, Hch1, modifies yeast Hsp90 (Hsp82) through Y606E phosphomimetic mutation raising the possibility that this post-translational modification in higher eukaryotes represents an evolutionary substitution for ... PMID: 28537252
2. The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922. PMID: 23166640
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

AHA1 family
數據庫鏈接：

KEGG: sce:YNL281W

STRING: 4932.YNL281W