在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Saccharomyces cerevisiae DNA-directed RNA polymerase II subunit RPB4 (RPB4)

Recombinant Saccharomyces cerevisiae DNA-directed RNA polymerase II subunit RPB4 (RPB4)

  • 中文名稱：
    釀酒酵母RPB4重組蛋白
  • 貨號：
    CSB-YP018331SVG
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母RPB4重組蛋白
  • 貨號：
    CSB-EP018331SVG
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母RPB4重組蛋白
  • 貨號：
    CSB-EP018331SVG-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母RPB4重組蛋白
  • 貨號：
    CSB-BP018331SVG
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母RPB4重組蛋白
  • 貨號：
    CSB-MP018331SVG
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RPB4
  • Uniprot No.：
  • 別名：
    RPB4; YJL140W; J0654; DNA-directed RNA polymerase II subunit RPB4; RNA polymerase II subunit B4; B32; DNA-directed RNA polymerase II 32 kDa polypeptide
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-221
  • 氨基酸序列
    MNVSTSTFQT RRRRLKKVEE EENAATLQLG QEFQLKQINH QGEEEELIAL NLSEARLVIK EALVERRRAF KRSQKKHKKK HLKHENANDE TTAVEDEDDD LDEDDVNADD DDFMHSETRE KELESIDVLL EQTTGGNNKD LKNTMQYLTN FSRFRDQETV GAVIQLLKST GLHPFEVAQL GSLACDTADE AKTLIPSLNN KISDDELERI LKELSNLETL Y
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex is necessary for promoter-directed transcription initiation but is not required for recruitment of Pol II to active preinitiation complexes and seems to be dispensable for transcription elongation and termination. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. Involved in DNA repair of damage in the transcribed strand. RPB4 is dispensable under optimal growth conditions, but becomes essential during heat or cold shock and under nutrient depletion. Suppresses the RBP9-mediated transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER) but facilitates the RAD26-mediated TCR subpathway. Under stress conditions only, involved in mRNA export to the cytoplasm. Involved in mRNA decay. Promotes or enhances the deadenylation process of specific mRNAs and may recruit PAT1 and the LSM1-7 complex to these mRNAs, thus stimulating their decapping and further decay.
  • 基因功能參考文獻：
    1. Our data indicate that the environmental stress response that occurs in foot mutants depends mostly on a global post-transcriptional regulation mechanism which, in turn, depends on Rpb4-mRNA imprinting PMID: 27001033
    2. Rpb4 is a bona fide Pol II core subunit that functions mainly in mRNA synthesis. PMID: 24802753
    3. Rpb4 is required for elongation, in gene specific manner under certain conditions.Rpb4 assists Paf1 in elongation of FKS1 gene under cellular stress condition. PMID: 24780862
    4. Subunit of RNA polymerase II, Rpb4p, is required for the decay of a class of mRNAs whose products are involved in protein synthesis. PMID: 16357218
    5. Loss of Rpb4 reduces RNA polymerase II levels near 3' ends of multiple mRNA genes, decreases association of 3'-end processing factors, & alters polyadenylation site usage at the RNA14 gene. Rpb4 contributes to cotranscriptional 3'-end processing in vivo. PMID: 18195044
    6. This report provides the first instance of a distinct role for Rpb4 in transcription, which is independent of its interacting partner, Rpb7. PMID: 18441121
    7. Rpb4 is involved in the expression of genes downstream of the RAM pathway. PMID: 18687406

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Seems to shuttle between nucleus and cytoplasm in a complex with RPB7.
  • 蛋白家族：
    Eukaryotic RPB4 RNA polymerase subunit family
  • 數據庫鏈接：

    KEGG: sce:YJL140W

    STRING: 4932.YJL140W



主站蜘蛛池模板： 极品白嫩的小少妇| 成 人 社区在线视频| 成人a毛片视频免费看| 婷婷网色偷偷亚洲男人甘肃| 一边吃奶一边摸做爽视频| 久久在线视频免费观看| 日本不卡三区| 国产白丝精品爽爽久久蜜臀| 国产超碰人人做人人爱一二区视品| 99re久久精品国产首页| 曰韩人妻无码一区二区三区综合部| 伊人色综合久久天天五月婷| 人人妻人人澡人人爽人人精品97| 亚洲欧美人高清精品a∨| 67194熟妇在线直接进入| 玩超薄丝袜人妻的经历| 一本无码人妻在中文字幕免费 | 四虎影成人精品a片| 欧美黑人性暴力猛交喷水黑人巨大 | 亚洲人成77777在线播放网站不卡 国产 | 欧洲野花视频天堂视频p 亚洲aⅴ天堂av天堂无码 | 亚洲人成色77777在线观看大战| 国产女人18毛片水真多18精品 | 国产亚洲美女精品久久久| 午夜福利精品亚洲不卡| 日产精品卡2卡三卡乱码网站| 中文字幕人乱码中文| 欧美性猛交99久久久久99按摩| 色婷婷av一区二区三区之红樱桃| 午夜三级a三级三点| 伊人久久大香线蕉成人| av在线播放日韩亚洲欧| 成人区精品一区二区婷婷| 男人的天堂免费一区二区视频 | 亚洲亚洲人成综合网络| 国产精品亚洲专区无码web| 国产精品青青在线麻豆| 国产免费不卡av在线播放| 天天爽夜夜爽人人爽曰| 免费国产a国产片高清| 青草av久久一区二区三区| 日韩少妇人妻vs中文字幕|