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  4. Recombinant Saccharomyces cerevisiae Chromosome transmission fidelity protein 18 (CTF18), partial

Recombinant Saccharomyces cerevisiae Chromosome transmission fidelity protein 18 (CTF18), partial

  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Chromosome transmission fidelity protein 18(CTF18) ,partial
  • 貨號：
    CSB-YP343448SVG
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Chromosome transmission fidelity protein 18(CTF18) ,partial
  • 貨號：
    CSB-EP343448SVG
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Chromosome transmission fidelity protein 18(CTF18) ,partial
  • 貨號：
    CSB-EP343448SVG-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Chromosome transmission fidelity protein 18(CTF18) ,partial
  • 貨號：
    CSB-BP343448SVG
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Chromosome transmission fidelity protein 18(CTF18) ,partial
  • 貨號：
    CSB-MP343448SVG
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CTF18
  • Uniprot No.：
  • 別名：
    CTF18; CHL12; YMR078C; YM9582.03CChromosome transmission fidelity protein 18
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.
  • 基因功能參考文獻：
    1. These results indicate that the Ctf18-RFC/Polepsilon interaction plays a crucial role in maintaining genome stability in budding yeast, probably through recruitment of this PCNA loader to the replication fork. PMID: 26987677
    2. The findings indicate that the association of Ctf18-RFC with Pol at defective replication forks is a key step in activation of the S-phase checkpoint. PMID: 26250113
    3. Ctf18 confers protection against stalling or breaks at the replication fork in cells that either lack, or are compromised for, telomerase activity, which is likely to contribute another level to telomere size homeostasis. PMID: 24533124
    4. Ctf18 RFC-like complex modifies telomeric chromatin to make it competent for normal localization to the nuclear periphery. PMID: 16525505
    5. During chromatid cohesion establishment, Ctf18 is found at the DNA replication fork. PMID: 16962805

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Activator 1 small subunits family, CTF18 subfamily
  • 數(shù)據(jù)庫鏈接：

    KEGG: sce:YMR078C

    STRING: 4932.YMR078C



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